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Modelling of Tissue Invasion in Epithelial Monolayers

Mathematical and computational models are used to describe biomechanical processes in multicellular systems. Here, we develop a model to analyse how two types of epithelial cell layers interact during tissue invasion depending on their cellular properties, i.e., simulating cancer cells expanding int...

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Detalles Bibliográficos
Autores principales: Alsubaie, Faris Saad, Khataee, Hamid, Neufeld, Zoltan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964186/
https://www.ncbi.nlm.nih.gov/pubmed/36836784
http://dx.doi.org/10.3390/life13020427
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author Alsubaie, Faris Saad
Khataee, Hamid
Neufeld, Zoltan
author_facet Alsubaie, Faris Saad
Khataee, Hamid
Neufeld, Zoltan
author_sort Alsubaie, Faris Saad
collection PubMed
description Mathematical and computational models are used to describe biomechanical processes in multicellular systems. Here, we develop a model to analyse how two types of epithelial cell layers interact during tissue invasion depending on their cellular properties, i.e., simulating cancer cells expanding into a region of normal cells. We model the tissue invasion process using the cellular Potts model and implement our two-dimensional computational simulations in the software package CompuCell3D. The model predicts that differences in mechanical properties of cells can lead to tissue invasion, even if the division rates and death rates of the two cell types are the same. We also show how the invasion speed varies depending on the cell division and death rates and the mechanical properties of the cells.
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spelling pubmed-99641862023-02-26 Modelling of Tissue Invasion in Epithelial Monolayers Alsubaie, Faris Saad Khataee, Hamid Neufeld, Zoltan Life (Basel) Article Mathematical and computational models are used to describe biomechanical processes in multicellular systems. Here, we develop a model to analyse how two types of epithelial cell layers interact during tissue invasion depending on their cellular properties, i.e., simulating cancer cells expanding into a region of normal cells. We model the tissue invasion process using the cellular Potts model and implement our two-dimensional computational simulations in the software package CompuCell3D. The model predicts that differences in mechanical properties of cells can lead to tissue invasion, even if the division rates and death rates of the two cell types are the same. We also show how the invasion speed varies depending on the cell division and death rates and the mechanical properties of the cells. MDPI 2023-02-02 /pmc/articles/PMC9964186/ /pubmed/36836784 http://dx.doi.org/10.3390/life13020427 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alsubaie, Faris Saad
Khataee, Hamid
Neufeld, Zoltan
Modelling of Tissue Invasion in Epithelial Monolayers
title Modelling of Tissue Invasion in Epithelial Monolayers
title_full Modelling of Tissue Invasion in Epithelial Monolayers
title_fullStr Modelling of Tissue Invasion in Epithelial Monolayers
title_full_unstemmed Modelling of Tissue Invasion in Epithelial Monolayers
title_short Modelling of Tissue Invasion in Epithelial Monolayers
title_sort modelling of tissue invasion in epithelial monolayers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964186/
https://www.ncbi.nlm.nih.gov/pubmed/36836784
http://dx.doi.org/10.3390/life13020427
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