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Modelling of Tissue Invasion in Epithelial Monolayers
Mathematical and computational models are used to describe biomechanical processes in multicellular systems. Here, we develop a model to analyse how two types of epithelial cell layers interact during tissue invasion depending on their cellular properties, i.e., simulating cancer cells expanding int...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964186/ https://www.ncbi.nlm.nih.gov/pubmed/36836784 http://dx.doi.org/10.3390/life13020427 |
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author | Alsubaie, Faris Saad Khataee, Hamid Neufeld, Zoltan |
author_facet | Alsubaie, Faris Saad Khataee, Hamid Neufeld, Zoltan |
author_sort | Alsubaie, Faris Saad |
collection | PubMed |
description | Mathematical and computational models are used to describe biomechanical processes in multicellular systems. Here, we develop a model to analyse how two types of epithelial cell layers interact during tissue invasion depending on their cellular properties, i.e., simulating cancer cells expanding into a region of normal cells. We model the tissue invasion process using the cellular Potts model and implement our two-dimensional computational simulations in the software package CompuCell3D. The model predicts that differences in mechanical properties of cells can lead to tissue invasion, even if the division rates and death rates of the two cell types are the same. We also show how the invasion speed varies depending on the cell division and death rates and the mechanical properties of the cells. |
format | Online Article Text |
id | pubmed-9964186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99641862023-02-26 Modelling of Tissue Invasion in Epithelial Monolayers Alsubaie, Faris Saad Khataee, Hamid Neufeld, Zoltan Life (Basel) Article Mathematical and computational models are used to describe biomechanical processes in multicellular systems. Here, we develop a model to analyse how two types of epithelial cell layers interact during tissue invasion depending on their cellular properties, i.e., simulating cancer cells expanding into a region of normal cells. We model the tissue invasion process using the cellular Potts model and implement our two-dimensional computational simulations in the software package CompuCell3D. The model predicts that differences in mechanical properties of cells can lead to tissue invasion, even if the division rates and death rates of the two cell types are the same. We also show how the invasion speed varies depending on the cell division and death rates and the mechanical properties of the cells. MDPI 2023-02-02 /pmc/articles/PMC9964186/ /pubmed/36836784 http://dx.doi.org/10.3390/life13020427 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alsubaie, Faris Saad Khataee, Hamid Neufeld, Zoltan Modelling of Tissue Invasion in Epithelial Monolayers |
title | Modelling of Tissue Invasion in Epithelial Monolayers |
title_full | Modelling of Tissue Invasion in Epithelial Monolayers |
title_fullStr | Modelling of Tissue Invasion in Epithelial Monolayers |
title_full_unstemmed | Modelling of Tissue Invasion in Epithelial Monolayers |
title_short | Modelling of Tissue Invasion in Epithelial Monolayers |
title_sort | modelling of tissue invasion in epithelial monolayers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964186/ https://www.ncbi.nlm.nih.gov/pubmed/36836784 http://dx.doi.org/10.3390/life13020427 |
work_keys_str_mv | AT alsubaiefarissaad modellingoftissueinvasioninepithelialmonolayers AT khataeehamid modellingoftissueinvasioninepithelialmonolayers AT neufeldzoltan modellingoftissueinvasioninepithelialmonolayers |