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Evaluation of New Potential Inflammatory Markers in Patients with Nonvalvular Atrial Fibrillation

Atrial fibrillation (AF), the most common arrhythmia in clinical practice, is associated with an increase in mortality and morbidity due to its high potential to cause stroke and systemic thromboembolism. Inflammatory mechanisms may play a role in the pathogenesis of AF and its maintenance. We aimed...

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Autores principales: Martins, Gabriela Lopes, Duarte, Rita Carolina Figueiredo, Vieira, Érica Leandro Marciano, Rocha, Natália Pessoa, Figueiredo, Estêvão Lanna, Silveira, Francisco Rezende, Caiaffa, José Raymundo Sollero, Lanna, Rodrigo Pinheiro, Carvalho, Maria das Graças, Palotás, András, Ferreira, Cláudia Natália, Reis, Helton José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964249/
https://www.ncbi.nlm.nih.gov/pubmed/36834735
http://dx.doi.org/10.3390/ijms24043326
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author Martins, Gabriela Lopes
Duarte, Rita Carolina Figueiredo
Vieira, Érica Leandro Marciano
Rocha, Natália Pessoa
Figueiredo, Estêvão Lanna
Silveira, Francisco Rezende
Caiaffa, José Raymundo Sollero
Lanna, Rodrigo Pinheiro
Carvalho, Maria das Graças
Palotás, András
Ferreira, Cláudia Natália
Reis, Helton José
author_facet Martins, Gabriela Lopes
Duarte, Rita Carolina Figueiredo
Vieira, Érica Leandro Marciano
Rocha, Natália Pessoa
Figueiredo, Estêvão Lanna
Silveira, Francisco Rezende
Caiaffa, José Raymundo Sollero
Lanna, Rodrigo Pinheiro
Carvalho, Maria das Graças
Palotás, András
Ferreira, Cláudia Natália
Reis, Helton José
author_sort Martins, Gabriela Lopes
collection PubMed
description Atrial fibrillation (AF), the most common arrhythmia in clinical practice, is associated with an increase in mortality and morbidity due to its high potential to cause stroke and systemic thromboembolism. Inflammatory mechanisms may play a role in the pathogenesis of AF and its maintenance. We aimed to evaluate a range of inflammatory markers as potentially involved in the pathophysiology of individuals with nonvalvular AF (NVAF). A total of 105 subjects were enrolled and divided into two groups: patients with NVAF (n = 55, mean age 72 ± 8 years) and a control group of individuals in sinus rhythm (n = 50, mean age 71 ± 8 years). Inflammatory-related mediators were quantified in plasma samples by using Cytometric Bead Array and Multiplex immunoassay. Subjects with NVAF presented significantly elevated values of interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor (TNF), interferon-gamma, growth differentiation factor-15, myeloperoxidase, as well as IL-4, interferon-gamma-induced protein (IP-10), monokine induced by interferon-gamma, neutrophil gelatinase-associated lipocalin, and serum amyloid A in comparison with controls. However, after multivariate regression analysis adjusting for confounding factors, only IL-6, IL-10, TNF, and IP-10 remained significantly associated with AF. We provided a basis for the study of inflammatory markers whose association with AF has not been addressed before, such as IP-10, in addition to supporting evidence about molecules that had previously been associated with the disease. We expect to contribute to the discovery of markers that can be implemented in clinical practice hereafter.
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spelling pubmed-99642492023-02-26 Evaluation of New Potential Inflammatory Markers in Patients with Nonvalvular Atrial Fibrillation Martins, Gabriela Lopes Duarte, Rita Carolina Figueiredo Vieira, Érica Leandro Marciano Rocha, Natália Pessoa Figueiredo, Estêvão Lanna Silveira, Francisco Rezende Caiaffa, José Raymundo Sollero Lanna, Rodrigo Pinheiro Carvalho, Maria das Graças Palotás, András Ferreira, Cláudia Natália Reis, Helton José Int J Mol Sci Article Atrial fibrillation (AF), the most common arrhythmia in clinical practice, is associated with an increase in mortality and morbidity due to its high potential to cause stroke and systemic thromboembolism. Inflammatory mechanisms may play a role in the pathogenesis of AF and its maintenance. We aimed to evaluate a range of inflammatory markers as potentially involved in the pathophysiology of individuals with nonvalvular AF (NVAF). A total of 105 subjects were enrolled and divided into two groups: patients with NVAF (n = 55, mean age 72 ± 8 years) and a control group of individuals in sinus rhythm (n = 50, mean age 71 ± 8 years). Inflammatory-related mediators were quantified in plasma samples by using Cytometric Bead Array and Multiplex immunoassay. Subjects with NVAF presented significantly elevated values of interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor (TNF), interferon-gamma, growth differentiation factor-15, myeloperoxidase, as well as IL-4, interferon-gamma-induced protein (IP-10), monokine induced by interferon-gamma, neutrophil gelatinase-associated lipocalin, and serum amyloid A in comparison with controls. However, after multivariate regression analysis adjusting for confounding factors, only IL-6, IL-10, TNF, and IP-10 remained significantly associated with AF. We provided a basis for the study of inflammatory markers whose association with AF has not been addressed before, such as IP-10, in addition to supporting evidence about molecules that had previously been associated with the disease. We expect to contribute to the discovery of markers that can be implemented in clinical practice hereafter. MDPI 2023-02-07 /pmc/articles/PMC9964249/ /pubmed/36834735 http://dx.doi.org/10.3390/ijms24043326 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Martins, Gabriela Lopes
Duarte, Rita Carolina Figueiredo
Vieira, Érica Leandro Marciano
Rocha, Natália Pessoa
Figueiredo, Estêvão Lanna
Silveira, Francisco Rezende
Caiaffa, José Raymundo Sollero
Lanna, Rodrigo Pinheiro
Carvalho, Maria das Graças
Palotás, András
Ferreira, Cláudia Natália
Reis, Helton José
Evaluation of New Potential Inflammatory Markers in Patients with Nonvalvular Atrial Fibrillation
title Evaluation of New Potential Inflammatory Markers in Patients with Nonvalvular Atrial Fibrillation
title_full Evaluation of New Potential Inflammatory Markers in Patients with Nonvalvular Atrial Fibrillation
title_fullStr Evaluation of New Potential Inflammatory Markers in Patients with Nonvalvular Atrial Fibrillation
title_full_unstemmed Evaluation of New Potential Inflammatory Markers in Patients with Nonvalvular Atrial Fibrillation
title_short Evaluation of New Potential Inflammatory Markers in Patients with Nonvalvular Atrial Fibrillation
title_sort evaluation of new potential inflammatory markers in patients with nonvalvular atrial fibrillation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964249/
https://www.ncbi.nlm.nih.gov/pubmed/36834735
http://dx.doi.org/10.3390/ijms24043326
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