Cargando…

Extremely Low Activity of Serum Alanine Aminotransferase Is Associated with Long-Term Overall-Cause Mortality in the Elderly Patients Undergoing Percutaneous Coronary Intervention after Acute Coronary Syndrome

Background and Objectives: Recent studies revealed that the extremely low activity of serum alanine aminotransferase (ALT) is associated with frailty and contributes to increased mortality after acute physical stress. We aimed to investigate whether the extremely low activity of serum ALT (<10 U/...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Doo Young, Park, Si-Woon, Han, Hyung-Wook, Kim, Myeong-Kon, Kim, Ha-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964269/
https://www.ncbi.nlm.nih.gov/pubmed/36837617
http://dx.doi.org/10.3390/medicina59020415
_version_ 1784896461647904768
author Kim, Doo Young
Park, Si-Woon
Han, Hyung-Wook
Kim, Myeong-Kon
Kim, Ha-Jung
author_facet Kim, Doo Young
Park, Si-Woon
Han, Hyung-Wook
Kim, Myeong-Kon
Kim, Ha-Jung
author_sort Kim, Doo Young
collection PubMed
description Background and Objectives: Recent studies revealed that the extremely low activity of serum alanine aminotransferase (ALT) is associated with frailty and contributes to increased mortality after acute physical stress. We aimed to investigate whether the extremely low activity of serum ALT (<10 U/L) at the time of diagnosis can be used to predict overall-cause mortality in elderly patients that underwent percutaneous coronary intervention (PCI) after acute coronary syndrome (ACS) diagnosis. Materials and Methods: A retrospective medical record review was performed on 1597 patients diagnosed with ACS who underwent PCI at a single university hospital from February 2014 to March 2020. The associations between the extremely low activity of serum ALT and mortality were assessed using a stepwise Cox regression (forward: conditional). Results: A total of 210 elderly patients were analyzed in this study. The number of deaths was 64 (30.5%), the mean survival time was 25.0 ± 18.9 months, and the mean age was 76.9 ± 7.6 years. The mean door-to-PCI time was 74.0 ± 20.9 min. The results of stepwise Cox regression analysis showed that the extremely low activity of serum ALT (adjusted hazard ratio: 5.157, 95% confidence interval: 3.001–8.862, p < 0.001) was the independent risk factor for long-term overall-cause mortality in the elderly who underwent PCI after ACS diagnosis. Conclusions: The extremely low activity of serum ALT at ACS diagnosis is a significant risk factor for increased long-term overall-cause mortality in the elderly who underwent PCI after ACS diagnosis. It is noteworthy that a simple laboratory test at the time of diagnosis was found to be a significant risk factor for mortality.
format Online
Article
Text
id pubmed-9964269
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99642692023-02-26 Extremely Low Activity of Serum Alanine Aminotransferase Is Associated with Long-Term Overall-Cause Mortality in the Elderly Patients Undergoing Percutaneous Coronary Intervention after Acute Coronary Syndrome Kim, Doo Young Park, Si-Woon Han, Hyung-Wook Kim, Myeong-Kon Kim, Ha-Jung Medicina (Kaunas) Article Background and Objectives: Recent studies revealed that the extremely low activity of serum alanine aminotransferase (ALT) is associated with frailty and contributes to increased mortality after acute physical stress. We aimed to investigate whether the extremely low activity of serum ALT (<10 U/L) at the time of diagnosis can be used to predict overall-cause mortality in elderly patients that underwent percutaneous coronary intervention (PCI) after acute coronary syndrome (ACS) diagnosis. Materials and Methods: A retrospective medical record review was performed on 1597 patients diagnosed with ACS who underwent PCI at a single university hospital from February 2014 to March 2020. The associations between the extremely low activity of serum ALT and mortality were assessed using a stepwise Cox regression (forward: conditional). Results: A total of 210 elderly patients were analyzed in this study. The number of deaths was 64 (30.5%), the mean survival time was 25.0 ± 18.9 months, and the mean age was 76.9 ± 7.6 years. The mean door-to-PCI time was 74.0 ± 20.9 min. The results of stepwise Cox regression analysis showed that the extremely low activity of serum ALT (adjusted hazard ratio: 5.157, 95% confidence interval: 3.001–8.862, p < 0.001) was the independent risk factor for long-term overall-cause mortality in the elderly who underwent PCI after ACS diagnosis. Conclusions: The extremely low activity of serum ALT at ACS diagnosis is a significant risk factor for increased long-term overall-cause mortality in the elderly who underwent PCI after ACS diagnosis. It is noteworthy that a simple laboratory test at the time of diagnosis was found to be a significant risk factor for mortality. MDPI 2023-02-20 /pmc/articles/PMC9964269/ /pubmed/36837617 http://dx.doi.org/10.3390/medicina59020415 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Doo Young
Park, Si-Woon
Han, Hyung-Wook
Kim, Myeong-Kon
Kim, Ha-Jung
Extremely Low Activity of Serum Alanine Aminotransferase Is Associated with Long-Term Overall-Cause Mortality in the Elderly Patients Undergoing Percutaneous Coronary Intervention after Acute Coronary Syndrome
title Extremely Low Activity of Serum Alanine Aminotransferase Is Associated with Long-Term Overall-Cause Mortality in the Elderly Patients Undergoing Percutaneous Coronary Intervention after Acute Coronary Syndrome
title_full Extremely Low Activity of Serum Alanine Aminotransferase Is Associated with Long-Term Overall-Cause Mortality in the Elderly Patients Undergoing Percutaneous Coronary Intervention after Acute Coronary Syndrome
title_fullStr Extremely Low Activity of Serum Alanine Aminotransferase Is Associated with Long-Term Overall-Cause Mortality in the Elderly Patients Undergoing Percutaneous Coronary Intervention after Acute Coronary Syndrome
title_full_unstemmed Extremely Low Activity of Serum Alanine Aminotransferase Is Associated with Long-Term Overall-Cause Mortality in the Elderly Patients Undergoing Percutaneous Coronary Intervention after Acute Coronary Syndrome
title_short Extremely Low Activity of Serum Alanine Aminotransferase Is Associated with Long-Term Overall-Cause Mortality in the Elderly Patients Undergoing Percutaneous Coronary Intervention after Acute Coronary Syndrome
title_sort extremely low activity of serum alanine aminotransferase is associated with long-term overall-cause mortality in the elderly patients undergoing percutaneous coronary intervention after acute coronary syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964269/
https://www.ncbi.nlm.nih.gov/pubmed/36837617
http://dx.doi.org/10.3390/medicina59020415
work_keys_str_mv AT kimdooyoung extremelylowactivityofserumalanineaminotransferaseisassociatedwithlongtermoverallcausemortalityintheelderlypatientsundergoingpercutaneouscoronaryinterventionafteracutecoronarysyndrome
AT parksiwoon extremelylowactivityofserumalanineaminotransferaseisassociatedwithlongtermoverallcausemortalityintheelderlypatientsundergoingpercutaneouscoronaryinterventionafteracutecoronarysyndrome
AT hanhyungwook extremelylowactivityofserumalanineaminotransferaseisassociatedwithlongtermoverallcausemortalityintheelderlypatientsundergoingpercutaneouscoronaryinterventionafteracutecoronarysyndrome
AT kimmyeongkon extremelylowactivityofserumalanineaminotransferaseisassociatedwithlongtermoverallcausemortalityintheelderlypatientsundergoingpercutaneouscoronaryinterventionafteracutecoronarysyndrome
AT kimhajung extremelylowactivityofserumalanineaminotransferaseisassociatedwithlongtermoverallcausemortalityintheelderlypatientsundergoingpercutaneouscoronaryinterventionafteracutecoronarysyndrome