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Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers
Proteins-derived polymeric micelles have gained attention and revolutionized the biomedical field. Proteins are considered a favorable choice for developing micelles because of their biocompatibility, harmlessness, greater blood circulation and solubilization of poorly soluble drugs. They exhibit gr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964340/ https://www.ncbi.nlm.nih.gov/pubmed/36850121 http://dx.doi.org/10.3390/polym15040836 |
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author | Mustafai, Aleena Zubair, Muhammad Hussain, Ajaz Ullah, Aman |
author_facet | Mustafai, Aleena Zubair, Muhammad Hussain, Ajaz Ullah, Aman |
author_sort | Mustafai, Aleena |
collection | PubMed |
description | Proteins-derived polymeric micelles have gained attention and revolutionized the biomedical field. Proteins are considered a favorable choice for developing micelles because of their biocompatibility, harmlessness, greater blood circulation and solubilization of poorly soluble drugs. They exhibit great potential in drug delivery systems as capable of controlled loading, distribution and function of loaded agents to the targeted sites within the body. Protein micelles successfully cross biological barriers and can be incorporated into various formulation designs employed in biomedical applications. This review emphasizes the recent advances of protein-based polymeric micelles for drug delivery to targeted sites of various diseases. Most studied protein-based micelles such as soy, gelatin, casein and collagen are discussed in detail, and their applications are highlighted. Finally, the future perspectives and forthcoming challenges for protein-based polymeric micelles have been reviewed with anticipated further advances. |
format | Online Article Text |
id | pubmed-9964340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99643402023-02-26 Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers Mustafai, Aleena Zubair, Muhammad Hussain, Ajaz Ullah, Aman Polymers (Basel) Review Proteins-derived polymeric micelles have gained attention and revolutionized the biomedical field. Proteins are considered a favorable choice for developing micelles because of their biocompatibility, harmlessness, greater blood circulation and solubilization of poorly soluble drugs. They exhibit great potential in drug delivery systems as capable of controlled loading, distribution and function of loaded agents to the targeted sites within the body. Protein micelles successfully cross biological barriers and can be incorporated into various formulation designs employed in biomedical applications. This review emphasizes the recent advances of protein-based polymeric micelles for drug delivery to targeted sites of various diseases. Most studied protein-based micelles such as soy, gelatin, casein and collagen are discussed in detail, and their applications are highlighted. Finally, the future perspectives and forthcoming challenges for protein-based polymeric micelles have been reviewed with anticipated further advances. MDPI 2023-02-08 /pmc/articles/PMC9964340/ /pubmed/36850121 http://dx.doi.org/10.3390/polym15040836 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mustafai, Aleena Zubair, Muhammad Hussain, Ajaz Ullah, Aman Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers |
title | Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers |
title_full | Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers |
title_fullStr | Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers |
title_full_unstemmed | Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers |
title_short | Recent Progress in Proteins-Based Micelles as Drug Delivery Carriers |
title_sort | recent progress in proteins-based micelles as drug delivery carriers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964340/ https://www.ncbi.nlm.nih.gov/pubmed/36850121 http://dx.doi.org/10.3390/polym15040836 |
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