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Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus
SIMPLE SUMMARY: Somatostatin expression in the hippocampus is transiently increased during the postnatal development of the hippocampus and decreased after P21. This study suggests that expression of SST is closely associated with postnatal neuroblast differentiation in the hippocampus. ABSTRACT: (1...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964365/ https://www.ncbi.nlm.nih.gov/pubmed/36851385 http://dx.doi.org/10.3390/vetsci10020081 |
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author | Yoo, Dae Young Kim, Woosuk Jung, Hyo Young Hwang, In Koo |
author_facet | Yoo, Dae Young Kim, Woosuk Jung, Hyo Young Hwang, In Koo |
author_sort | Yoo, Dae Young |
collection | PubMed |
description | SIMPLE SUMMARY: Somatostatin expression in the hippocampus is transiently increased during the postnatal development of the hippocampus and decreased after P21. This study suggests that expression of SST is closely associated with postnatal neuroblast differentiation in the hippocampus. ABSTRACT: (1) Background: Somatostatin (SST) exhibits expressional changes in the brain during development, but its role is not still clear in brain development. (2) Methods: We investigated postnatal SST expression and its effects on hippocampal neurogenesis via administering SST subcutaneously to P7 mice for 7 days. (3) Results: In the hippocampal CA1 region, SST immunoreactivity reaches peak at P14. However, SST immunoreactivity significantly decreased at P21. In the CA2/3 region, the SST expression pattern was similar to the CA1, and SST-immunoreactive cells were most abundant at P14. In the dentate gyrus, SST-immunoreactive cells were most abundant at P7 and P14 in the polymorphic layer; as in CA1-3 regions, the immunoreactivity decreased at P21. To elucidate the role of SST in postnatal development, we administered SST subcutaneously to P7 mice for 7 days. In the subgranular zone of the hippocampal dentate gyrus, a significant increase was observed in immunoreactivity of doublecortin (DCX)-positive neuroblast after administration of SST.; (4) Conclusions: SST expression in the hippocampal sub-regions is transiently increased during the postnatal formation of the hippocampus and decreases after P21. In addition, SST is involved in neuroblast differentiation in the dentate gyrus of the hippocampus. |
format | Online Article Text |
id | pubmed-9964365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99643652023-02-26 Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus Yoo, Dae Young Kim, Woosuk Jung, Hyo Young Hwang, In Koo Vet Sci Article SIMPLE SUMMARY: Somatostatin expression in the hippocampus is transiently increased during the postnatal development of the hippocampus and decreased after P21. This study suggests that expression of SST is closely associated with postnatal neuroblast differentiation in the hippocampus. ABSTRACT: (1) Background: Somatostatin (SST) exhibits expressional changes in the brain during development, but its role is not still clear in brain development. (2) Methods: We investigated postnatal SST expression and its effects on hippocampal neurogenesis via administering SST subcutaneously to P7 mice for 7 days. (3) Results: In the hippocampal CA1 region, SST immunoreactivity reaches peak at P14. However, SST immunoreactivity significantly decreased at P21. In the CA2/3 region, the SST expression pattern was similar to the CA1, and SST-immunoreactive cells were most abundant at P14. In the dentate gyrus, SST-immunoreactive cells were most abundant at P7 and P14 in the polymorphic layer; as in CA1-3 regions, the immunoreactivity decreased at P21. To elucidate the role of SST in postnatal development, we administered SST subcutaneously to P7 mice for 7 days. In the subgranular zone of the hippocampal dentate gyrus, a significant increase was observed in immunoreactivity of doublecortin (DCX)-positive neuroblast after administration of SST.; (4) Conclusions: SST expression in the hippocampal sub-regions is transiently increased during the postnatal formation of the hippocampus and decreases after P21. In addition, SST is involved in neuroblast differentiation in the dentate gyrus of the hippocampus. MDPI 2023-01-21 /pmc/articles/PMC9964365/ /pubmed/36851385 http://dx.doi.org/10.3390/vetsci10020081 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yoo, Dae Young Kim, Woosuk Jung, Hyo Young Hwang, In Koo Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus |
title | Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus |
title_full | Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus |
title_fullStr | Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus |
title_full_unstemmed | Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus |
title_short | Postnatal Changes of Somatostatin Expression in Hippocampi of C57BL/6 Mice; Modulation of Neuroblast Differentiation in the Hippocampus |
title_sort | postnatal changes of somatostatin expression in hippocampi of c57bl/6 mice; modulation of neuroblast differentiation in the hippocampus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964365/ https://www.ncbi.nlm.nih.gov/pubmed/36851385 http://dx.doi.org/10.3390/vetsci10020081 |
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