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mRNA-Based Therapeutics in Cancer Treatment
Over the past two decades, significant technological innovations have led to messenger RNA (mRNA) becoming a promising option for developing prophylactic and therapeutic vaccines, protein replacement therapies, and genome engineering. The success of the two COVID-19 mRNA vaccines has sparked new ent...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964383/ https://www.ncbi.nlm.nih.gov/pubmed/36839944 http://dx.doi.org/10.3390/pharmaceutics15020622 |
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author | Sun, Han Zhang, Yu Wang, Ge Yang, Wen Xu, Yingjie |
author_facet | Sun, Han Zhang, Yu Wang, Ge Yang, Wen Xu, Yingjie |
author_sort | Sun, Han |
collection | PubMed |
description | Over the past two decades, significant technological innovations have led to messenger RNA (mRNA) becoming a promising option for developing prophylactic and therapeutic vaccines, protein replacement therapies, and genome engineering. The success of the two COVID-19 mRNA vaccines has sparked new enthusiasm for other medical applications, particularly in cancer treatment. In vitro-transcribed (IVT) mRNAs are structurally designed to resemble naturally occurring mature mRNA. Delivery of IVT mRNA via delivery platforms such as lipid nanoparticles allows host cells to produce many copies of encoded proteins, which can serve as antigens to stimulate immune responses or as additional beneficial proteins for supplements. mRNA-based cancer therapeutics include mRNA cancer vaccines, mRNA encoding cytokines, chimeric antigen receptors, tumor suppressors, and other combination therapies. To better understand the current development and research status of mRNA therapies for cancer treatment, this review focused on the molecular design, delivery systems, and clinical indications of mRNA therapies in cancer. |
format | Online Article Text |
id | pubmed-9964383 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99643832023-02-26 mRNA-Based Therapeutics in Cancer Treatment Sun, Han Zhang, Yu Wang, Ge Yang, Wen Xu, Yingjie Pharmaceutics Review Over the past two decades, significant technological innovations have led to messenger RNA (mRNA) becoming a promising option for developing prophylactic and therapeutic vaccines, protein replacement therapies, and genome engineering. The success of the two COVID-19 mRNA vaccines has sparked new enthusiasm for other medical applications, particularly in cancer treatment. In vitro-transcribed (IVT) mRNAs are structurally designed to resemble naturally occurring mature mRNA. Delivery of IVT mRNA via delivery platforms such as lipid nanoparticles allows host cells to produce many copies of encoded proteins, which can serve as antigens to stimulate immune responses or as additional beneficial proteins for supplements. mRNA-based cancer therapeutics include mRNA cancer vaccines, mRNA encoding cytokines, chimeric antigen receptors, tumor suppressors, and other combination therapies. To better understand the current development and research status of mRNA therapies for cancer treatment, this review focused on the molecular design, delivery systems, and clinical indications of mRNA therapies in cancer. MDPI 2023-02-13 /pmc/articles/PMC9964383/ /pubmed/36839944 http://dx.doi.org/10.3390/pharmaceutics15020622 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sun, Han Zhang, Yu Wang, Ge Yang, Wen Xu, Yingjie mRNA-Based Therapeutics in Cancer Treatment |
title | mRNA-Based Therapeutics in Cancer Treatment |
title_full | mRNA-Based Therapeutics in Cancer Treatment |
title_fullStr | mRNA-Based Therapeutics in Cancer Treatment |
title_full_unstemmed | mRNA-Based Therapeutics in Cancer Treatment |
title_short | mRNA-Based Therapeutics in Cancer Treatment |
title_sort | mrna-based therapeutics in cancer treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964383/ https://www.ncbi.nlm.nih.gov/pubmed/36839944 http://dx.doi.org/10.3390/pharmaceutics15020622 |
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