Cargando…

Molecular Modeling and In Vitro Evaluation of Piplartine Analogs against Oral Squamous Cell Carcinoma

Cancer is a principal cause of death in the world, and providing a better quality of life and reducing mortality through effective pharmacological treatment remains a challenge. Among malignant tumor types, squamous cell carcinoma-esophageal cancer (EC) is usually located in the mouth, with approxim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Silva, Rayanne H. N., Machado, Thaíssa Q., da Fonseca, Anna Carolina C., Tejera, Eduardo, Perez-Castillo, Yunierkis, Robbs, Bruno K., de Sousa, Damião P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964404/ https://www.ncbi.nlm.nih.gov/pubmed/36838660 http://dx.doi.org/10.3390/molecules28041675

Ejemplares similares

Piplartine-Inspired 3,4,5-Trimethoxycinnamates: Trypanocidal, Mechanism of Action, and In Silico Evaluation
por: Filho, Carlos S. M. B., et al.
Publicado: (2023)

Piplartine Analogues and Cytotoxic Evaluation against Glioblastoma
por: da Nóbrega, Flávio Rogério, et al.
Publicado: (2018)

The Antitumor Activity of Piplartine: A Review
por: Duarte, Allana Brunna S., et al.
Publicado: (2023)

A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update
por: Machado, Thaíssa Q., et al.
Publicado: (2022)

Biological and physical approaches on the role of piplartine (piperlongumine) in cancer
por: Henrique, Tiago, et al.
Publicado: (2020)

Synthesis of Coumarin and Homoisoflavonoid Derivatives and Analogs: The Search for New Antifungal Agents
por: Ferreira, Alana R., et al.
Publicado: (2022)

Trypanosoma cruzi: analysis of two different strains after piplartine treatment
por: Vieira, Gabriela Alves Licursi, et al.
Publicado: (2018)

The dilemma of bacterial expansins evolution. The unusual case of Streptomyces acidiscabies and Kutzneria sp. 744
por: Armijos-Jaramillo, Vinicio, et al.
Publicado: (2018)

Schistosomiasis Control Using Piplartine against Biomphalaria glabrata at Different Developmental Stages
por: Rapado, Ludmila Nakamura, et al.
Publicado: (2013)

Anticancer Activity and Molecular Targets of Piper cernuum Substances in Oral Squamous Cell Carcinoma Models
por: Machado, Thaíssa Queiróz, et al.
Publicado: (2023)

Effect of piplartine and cinnamides on Leishmania amazonensis, Plasmodium falciparum and on peritoneal cells of Swiss mice
por: de Araújo-Vilges, Keline Medeiros, et al.
Publicado: (2017)

(E)-Piplartine Isolated from Piper pseudoarboreum, a Lead Compound against Leishmaniasis
por: Ticona, Juan C., et al.
Publicado: (2020)

A Multi-Objective Approach for Drug Repurposing in Preeclampsia
por: Tejera, Eduardo, et al.
Publicado: (2021)

A Novel MDM2-Binding Chalcone Induces Apoptosis of Oral Squamous Cell Carcinoma
por: Wermelinger, Guilherme Freimann, et al.
Publicado: (2023)

Structure–Activity Relationship of Piplartine and Synthetic Analogues against Schistosoma mansoni and Cytotoxicity to Mammalian Cells
por: Campelo, Yuri, et al.
Publicado: (2018)

Piplartine attenuates the proliferation of hepatocellular carcinoma cells via regulating hsa_circ_100338 expression
por: Cheng, Xiaoli, et al.
Publicado: (2020)

A putative antimicrobial peptide from Hymenoptera in the megaplasmid pSCL4 of Streptomyces clavuligerus ATCC 27064 reveals a singular case of horizontal gene transfer with potential applications
por: Ayala‐Ruano, Sebastián, et al.
Publicado: (2019)

Drugs Repurposing Using QSAR, Docking and Molecular Dynamics for Possible Inhibitors of the SARS-CoV-2 M(pro) Protease
por: Tejera, Eduardo, et al.
Publicado: (2020)

NFBTA: A Potent Cytotoxic Agent against Glioblastoma
por: Turkez, Hasan, et al.
Publicado: (2019)

A population-based study of preeclampsia and eclampsia in Ecuador: ethnic, geographical and altitudes differences
por: Tejera, Eduardo, et al.
Publicado: (2021)

Gallic Acid Alkyl Esters: Trypanocidal and Leishmanicidal Activity, and Target Identification via Modeling Studies
por: Steverding, Dietmar, et al.
Publicado: (2022)

Novel piplartine-containing ruthenium complexes: synthesis, cell growth inhibition, apoptosis induction and ROS production on HCT116 cells
por: D’Sousa Costa, Cinara O., et al.
Publicado: (2017)

Critical Review of Plant-Derived Compounds as Possible Inhibitors of SARS-CoV-2 Proteases: A Comparison with Experimentally Validated Molecules
por: Guerra, Yasel, et al.
Publicado: (2022)

Synthetic Cinnamides and Cinnamates: Antimicrobial Activity, Mechanism of Action, and In Silico Study
por: de Morais, Mayara Castro, et al.
Publicado: (2023)

ShadowCaster: Compositional Methods under the Shadow of Phylogenetic Models to Detect Horizontal Gene Transfers in Prokaryotes
por: Sánchez-Soto, Daniela, et al.
Publicado: (2020)

Computational modeling predicts potential effects of the herbal infusion “horchata” against COVID-19
por: Tejera, Eduardo, et al.
Publicado: (2022)

Alkyl and Aryl Derivatives Based on p-Coumaric Acid Modification and Inhibitory Action against Leishmania braziliensis and Plasmodium falciparum
por: Lopes, Susiany P., et al.
Publicado: (2020)

Larvicidal Activity of Cinnamic Acid Derivatives: Investigating Alternative Products for Aedes aegypti L. Control
por: Araújo, Marianna O., et al.
Publicado: (2020)

Perturbation-Theory Machine Learning (PTML) Multilabel Model of the ChEMBL Dataset of Preclinical Assays for Antisarcoma Compounds
por: Cabrera-Andrade, Alejandro, et al.
Publicado: (2020)

A Multi-Objective Approach for Anti-Osteosarcoma Cancer Agents Discovery through Drug Repurposing
por: Cabrera-Andrade, Alejandro, et al.
Publicado: (2020)

A desirability-based multi objective approach for the virtual screening discovery of broad-spectrum anti-gastric cancer agents
por: Perez-Castillo, Yunierkis, et al.
Publicado: (2018)

Bioactive Terpenes and Their Derivatives as Potential SARS-CoV-2 Proteases Inhibitors from Molecular Modeling Studies
por: Diniz, Lúcio Ricardo Leite, et al.
Publicado: (2021)

Pro-Apoptotic Antitumoral Effect of Novel Acridine-Core Naphthoquinone Compounds against Oral Squamous Cell Carcinoma
por: Zorzanelli, Bruna Costa, et al.
Publicado: (2022)

Protective Effect of Piplartine against LPS-Induced Sepsis through Attenuating the MAPKs/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation
por: Huang, Chi-Han, et al.
Publicado: (2021)

Fusing Docking Scoring Functions Improves the Virtual Screening Performance for Discovering Parkinson’s Disease Dual Target Ligands
por: Perez-Castillo, Yunierkis, et al.
Publicado: (2017)

Efficient and biologically relevant consensus strategy for Parkinson’s disease gene prioritization
por: Cruz-Monteagudo, Maykel, et al.
Publicado: (2016)

Gene prioritization, communality analysis, networking and metabolic integrated pathway to better understand breast cancer pathogenesis
por: López-Cortés, Andrés, et al.
Publicado: (2018)

Gene Prioritization through Consensus Strategy, Enrichment Methodologies Analysis, and Networking for Osteosarcoma Pathogenesis
por: Cabrera-Andrade, Alejandro, et al.
Publicado: (2020)

Chemoinformatics Profiling of the Chromone Nucleus as a MAO-B/A(2A)AR Dual Binding Scaffold
por: Cruz-Monteagudo, Maykel, et al.
Publicado: (2017)

Multistep process of squamous differentiation in tracheobronchial epithelial cells in vitro: analogy with epidermal differentiation.
por: Jetten, A M
Publicado: (1989)

Cannot write session to /tmp/vufind_sessions/sess_6jdvvr9eiccgmpvbrgliiv4tmt