A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line

A dinuclear Pt(II) complex with putrescine as bridging polyamine ligand ([Pt(2)Put(2)(NH(3))(4)]Cl(4)) was synthesized and assessed as to its potential anticancer activity against a human non-small cell lung cancer line (A549), as well as towards non-cancer cells (BEAS-2B). This effect was evaluated...

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Detalles Bibliográficos
Autores principales: Silva, Jéssica D., Marques, Joana, Santos, Inês P., Batista de Carvalho, Ana L. M., Martins, Clara B., Laginha, Raquel C., Batista de Carvalho, Luís A. E., Marques, Maria Paula M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964417/
https://www.ncbi.nlm.nih.gov/pubmed/36838683
http://dx.doi.org/10.3390/molecules28041698
Descripción
Sumario:A dinuclear Pt(II) complex with putrescine as bridging polyamine ligand ([Pt(2)Put(2)(NH(3))(4)]Cl(4)) was synthesized and assessed as to its potential anticancer activity against a human non-small cell lung cancer line (A549), as well as towards non-cancer cells (BEAS-2B). This effect was evaluated through in vitro cytotoxicity assays (MTT and SRB) coupled to microFTIR and microRaman spectroscopies, the former delivering information on growth-inhibiting and cytotoxic abilities while the latter provided very specific information on the metabolic impact of the metal agent (at the sub-cellular level). Regarding cancer cells, a major impact of [Pt(2)Put(2)(NH(3))(4)]Cl(4) was evidenced on cellular proteins and lipids, as compared to DNA, particularly via the Amide I and Amide II signals. The effect of the chelate on non-malignant cells was lower than on malignant ones, evidencing a promising low toxicity towards healthy cells.

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