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Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review

This systematic review was conducted to gather evidence of preeclampsia occurring before the 20th week of gestation, additionally considering the role of PLGF and sFlt-1 in the development of the disease. In the three cases of preeclampsia before the 20th week of gestation presented in the authors’...

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Autores principales: Modzelewski, Jan, Siarkowska, Iga, Pajurek-Dudek, Justyna, Feduniw, Stepan, Muzyka-Placzyńska, Katarzyna, Baran, Arkadiusz, Kajdy, Anna, Bednarek-Jędrzejek, Magdalena, Cymbaluk-Płoska, Aneta, Kwiatkowska, Ewa, Kwiatkowski, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964444/
https://www.ncbi.nlm.nih.gov/pubmed/36835158
http://dx.doi.org/10.3390/ijms24043752
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author Modzelewski, Jan
Siarkowska, Iga
Pajurek-Dudek, Justyna
Feduniw, Stepan
Muzyka-Placzyńska, Katarzyna
Baran, Arkadiusz
Kajdy, Anna
Bednarek-Jędrzejek, Magdalena
Cymbaluk-Płoska, Aneta
Kwiatkowska, Ewa
Kwiatkowski, Sebastian
author_facet Modzelewski, Jan
Siarkowska, Iga
Pajurek-Dudek, Justyna
Feduniw, Stepan
Muzyka-Placzyńska, Katarzyna
Baran, Arkadiusz
Kajdy, Anna
Bednarek-Jędrzejek, Magdalena
Cymbaluk-Płoska, Aneta
Kwiatkowska, Ewa
Kwiatkowski, Sebastian
author_sort Modzelewski, Jan
collection PubMed
description This systematic review was conducted to gather evidence of preeclampsia occurring before the 20th week of gestation, additionally considering the role of PLGF and sFlt-1 in the development of the disease. In the three cases of preeclampsia before the 20th week of gestation presented in the authors’ material, all pregnancies ended up with IUFD, and the SFlt-1/PLGF ratios were significantly elevated in all women. Eligible publications were identified with searches in the PubMed, Embase, Scopus, and Web of Science databases. No date or language restrictions were made. All original peer-reviewed scientific reports were included. A total of 30 publications were included in the final report, including case reports and case series. No other publication types regarding this issue were identified. In the literature, 34 cases of preeclampsia with onset occurring before the 20th week of gestation were identified, for a final total of 37 cases. Live births were reported in 5 cases (10.52%), and there were 9 intrauterine fetal demises (24.32%), and 23 terminations of pregnancy (62.16%). Preeclampsia before the 20th week of gestation is rare but can occur. We collected all available evidence regarding this phenomenon, with 37 cases reported worldwide. We call for large-scale cohort or register-based studies to establish revised definitions or develop new ones regarding the currently unrecognized very early onset preeclampsia.
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spelling pubmed-99644442023-02-26 Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review Modzelewski, Jan Siarkowska, Iga Pajurek-Dudek, Justyna Feduniw, Stepan Muzyka-Placzyńska, Katarzyna Baran, Arkadiusz Kajdy, Anna Bednarek-Jędrzejek, Magdalena Cymbaluk-Płoska, Aneta Kwiatkowska, Ewa Kwiatkowski, Sebastian Int J Mol Sci Review This systematic review was conducted to gather evidence of preeclampsia occurring before the 20th week of gestation, additionally considering the role of PLGF and sFlt-1 in the development of the disease. In the three cases of preeclampsia before the 20th week of gestation presented in the authors’ material, all pregnancies ended up with IUFD, and the SFlt-1/PLGF ratios were significantly elevated in all women. Eligible publications were identified with searches in the PubMed, Embase, Scopus, and Web of Science databases. No date or language restrictions were made. All original peer-reviewed scientific reports were included. A total of 30 publications were included in the final report, including case reports and case series. No other publication types regarding this issue were identified. In the literature, 34 cases of preeclampsia with onset occurring before the 20th week of gestation were identified, for a final total of 37 cases. Live births were reported in 5 cases (10.52%), and there were 9 intrauterine fetal demises (24.32%), and 23 terminations of pregnancy (62.16%). Preeclampsia before the 20th week of gestation is rare but can occur. We collected all available evidence regarding this phenomenon, with 37 cases reported worldwide. We call for large-scale cohort or register-based studies to establish revised definitions or develop new ones regarding the currently unrecognized very early onset preeclampsia. MDPI 2023-02-13 /pmc/articles/PMC9964444/ /pubmed/36835158 http://dx.doi.org/10.3390/ijms24043752 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Modzelewski, Jan
Siarkowska, Iga
Pajurek-Dudek, Justyna
Feduniw, Stepan
Muzyka-Placzyńska, Katarzyna
Baran, Arkadiusz
Kajdy, Anna
Bednarek-Jędrzejek, Magdalena
Cymbaluk-Płoska, Aneta
Kwiatkowska, Ewa
Kwiatkowski, Sebastian
Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review
title Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review
title_full Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review
title_fullStr Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review
title_full_unstemmed Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review
title_short Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review
title_sort atypical preeclampsia before 20 weeks of gestation—a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964444/
https://www.ncbi.nlm.nih.gov/pubmed/36835158
http://dx.doi.org/10.3390/ijms24043752
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