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Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review
This systematic review was conducted to gather evidence of preeclampsia occurring before the 20th week of gestation, additionally considering the role of PLGF and sFlt-1 in the development of the disease. In the three cases of preeclampsia before the 20th week of gestation presented in the authors’...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964444/ https://www.ncbi.nlm.nih.gov/pubmed/36835158 http://dx.doi.org/10.3390/ijms24043752 |
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author | Modzelewski, Jan Siarkowska, Iga Pajurek-Dudek, Justyna Feduniw, Stepan Muzyka-Placzyńska, Katarzyna Baran, Arkadiusz Kajdy, Anna Bednarek-Jędrzejek, Magdalena Cymbaluk-Płoska, Aneta Kwiatkowska, Ewa Kwiatkowski, Sebastian |
author_facet | Modzelewski, Jan Siarkowska, Iga Pajurek-Dudek, Justyna Feduniw, Stepan Muzyka-Placzyńska, Katarzyna Baran, Arkadiusz Kajdy, Anna Bednarek-Jędrzejek, Magdalena Cymbaluk-Płoska, Aneta Kwiatkowska, Ewa Kwiatkowski, Sebastian |
author_sort | Modzelewski, Jan |
collection | PubMed |
description | This systematic review was conducted to gather evidence of preeclampsia occurring before the 20th week of gestation, additionally considering the role of PLGF and sFlt-1 in the development of the disease. In the three cases of preeclampsia before the 20th week of gestation presented in the authors’ material, all pregnancies ended up with IUFD, and the SFlt-1/PLGF ratios were significantly elevated in all women. Eligible publications were identified with searches in the PubMed, Embase, Scopus, and Web of Science databases. No date or language restrictions were made. All original peer-reviewed scientific reports were included. A total of 30 publications were included in the final report, including case reports and case series. No other publication types regarding this issue were identified. In the literature, 34 cases of preeclampsia with onset occurring before the 20th week of gestation were identified, for a final total of 37 cases. Live births were reported in 5 cases (10.52%), and there were 9 intrauterine fetal demises (24.32%), and 23 terminations of pregnancy (62.16%). Preeclampsia before the 20th week of gestation is rare but can occur. We collected all available evidence regarding this phenomenon, with 37 cases reported worldwide. We call for large-scale cohort or register-based studies to establish revised definitions or develop new ones regarding the currently unrecognized very early onset preeclampsia. |
format | Online Article Text |
id | pubmed-9964444 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99644442023-02-26 Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review Modzelewski, Jan Siarkowska, Iga Pajurek-Dudek, Justyna Feduniw, Stepan Muzyka-Placzyńska, Katarzyna Baran, Arkadiusz Kajdy, Anna Bednarek-Jędrzejek, Magdalena Cymbaluk-Płoska, Aneta Kwiatkowska, Ewa Kwiatkowski, Sebastian Int J Mol Sci Review This systematic review was conducted to gather evidence of preeclampsia occurring before the 20th week of gestation, additionally considering the role of PLGF and sFlt-1 in the development of the disease. In the three cases of preeclampsia before the 20th week of gestation presented in the authors’ material, all pregnancies ended up with IUFD, and the SFlt-1/PLGF ratios were significantly elevated in all women. Eligible publications were identified with searches in the PubMed, Embase, Scopus, and Web of Science databases. No date or language restrictions were made. All original peer-reviewed scientific reports were included. A total of 30 publications were included in the final report, including case reports and case series. No other publication types regarding this issue were identified. In the literature, 34 cases of preeclampsia with onset occurring before the 20th week of gestation were identified, for a final total of 37 cases. Live births were reported in 5 cases (10.52%), and there were 9 intrauterine fetal demises (24.32%), and 23 terminations of pregnancy (62.16%). Preeclampsia before the 20th week of gestation is rare but can occur. We collected all available evidence regarding this phenomenon, with 37 cases reported worldwide. We call for large-scale cohort or register-based studies to establish revised definitions or develop new ones regarding the currently unrecognized very early onset preeclampsia. MDPI 2023-02-13 /pmc/articles/PMC9964444/ /pubmed/36835158 http://dx.doi.org/10.3390/ijms24043752 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Modzelewski, Jan Siarkowska, Iga Pajurek-Dudek, Justyna Feduniw, Stepan Muzyka-Placzyńska, Katarzyna Baran, Arkadiusz Kajdy, Anna Bednarek-Jędrzejek, Magdalena Cymbaluk-Płoska, Aneta Kwiatkowska, Ewa Kwiatkowski, Sebastian Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review |
title | Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review |
title_full | Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review |
title_fullStr | Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review |
title_full_unstemmed | Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review |
title_short | Atypical Preeclampsia before 20 Weeks of Gestation—A Systematic Review |
title_sort | atypical preeclampsia before 20 weeks of gestation—a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964444/ https://www.ncbi.nlm.nih.gov/pubmed/36835158 http://dx.doi.org/10.3390/ijms24043752 |
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