Cargando…

Altered White Matter Network Topology in Panic Disorder

Panic disorder (PD) is an anxiety disorder that impairs life quality and social function and is associated with distributed brain regions. However, the alteration of the structural network remains unclear in PD patients. This study explored the specific characteristics of the structural brain networ...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Molin, Zhang, Ping, Yang, Xiangyun, Yu, Aihong, Zhang, Jie, Xu, Xiaoyu, Li, Zhanjiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964494/
https://www.ncbi.nlm.nih.gov/pubmed/36836461
http://dx.doi.org/10.3390/jpm13020227
_version_ 1784896519992770560
author Jiang, Molin
Zhang, Ping
Yang, Xiangyun
Yu, Aihong
Zhang, Jie
Xu, Xiaoyu
Li, Zhanjiang
author_facet Jiang, Molin
Zhang, Ping
Yang, Xiangyun
Yu, Aihong
Zhang, Jie
Xu, Xiaoyu
Li, Zhanjiang
author_sort Jiang, Molin
collection PubMed
description Panic disorder (PD) is an anxiety disorder that impairs life quality and social function and is associated with distributed brain regions. However, the alteration of the structural network remains unclear in PD patients. This study explored the specific characteristics of the structural brain network in patients with PD by graph theory analysis of diffusion tensor images (DTI). A total of 81 PD patients and 48 matched healthy controls were recruited for this study. The structural networks were constructed, and the network topological properties for individuals were estimated. At the global level, the network efficiency was higher, while the shortest path length and clustering coefficient were lower in the PD group compared to the healthy control (HC) group. At the nodal level, the PD group showed a widespread higher nodal efficiency and lower average shortest path length in the prefrontal, sensorimotor, limbic, insula, and cerebellum regions. Overall, the current results showed that the alteration of information processing in the fear network might play a role in the pathophysiology of PD.
format Online
Article
Text
id pubmed-9964494
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99644942023-02-26 Altered White Matter Network Topology in Panic Disorder Jiang, Molin Zhang, Ping Yang, Xiangyun Yu, Aihong Zhang, Jie Xu, Xiaoyu Li, Zhanjiang J Pers Med Article Panic disorder (PD) is an anxiety disorder that impairs life quality and social function and is associated with distributed brain regions. However, the alteration of the structural network remains unclear in PD patients. This study explored the specific characteristics of the structural brain network in patients with PD by graph theory analysis of diffusion tensor images (DTI). A total of 81 PD patients and 48 matched healthy controls were recruited for this study. The structural networks were constructed, and the network topological properties for individuals were estimated. At the global level, the network efficiency was higher, while the shortest path length and clustering coefficient were lower in the PD group compared to the healthy control (HC) group. At the nodal level, the PD group showed a widespread higher nodal efficiency and lower average shortest path length in the prefrontal, sensorimotor, limbic, insula, and cerebellum regions. Overall, the current results showed that the alteration of information processing in the fear network might play a role in the pathophysiology of PD. MDPI 2023-01-27 /pmc/articles/PMC9964494/ /pubmed/36836461 http://dx.doi.org/10.3390/jpm13020227 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jiang, Molin
Zhang, Ping
Yang, Xiangyun
Yu, Aihong
Zhang, Jie
Xu, Xiaoyu
Li, Zhanjiang
Altered White Matter Network Topology in Panic Disorder
title Altered White Matter Network Topology in Panic Disorder
title_full Altered White Matter Network Topology in Panic Disorder
title_fullStr Altered White Matter Network Topology in Panic Disorder
title_full_unstemmed Altered White Matter Network Topology in Panic Disorder
title_short Altered White Matter Network Topology in Panic Disorder
title_sort altered white matter network topology in panic disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964494/
https://www.ncbi.nlm.nih.gov/pubmed/36836461
http://dx.doi.org/10.3390/jpm13020227
work_keys_str_mv AT jiangmolin alteredwhitematternetworktopologyinpanicdisorder
AT zhangping alteredwhitematternetworktopologyinpanicdisorder
AT yangxiangyun alteredwhitematternetworktopologyinpanicdisorder
AT yuaihong alteredwhitematternetworktopologyinpanicdisorder
AT zhangjie alteredwhitematternetworktopologyinpanicdisorder
AT xuxiaoyu alteredwhitematternetworktopologyinpanicdisorder
AT lizhanjiang alteredwhitematternetworktopologyinpanicdisorder