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Altered White Matter Network Topology in Panic Disorder
Panic disorder (PD) is an anxiety disorder that impairs life quality and social function and is associated with distributed brain regions. However, the alteration of the structural network remains unclear in PD patients. This study explored the specific characteristics of the structural brain networ...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964494/ https://www.ncbi.nlm.nih.gov/pubmed/36836461 http://dx.doi.org/10.3390/jpm13020227 |
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author | Jiang, Molin Zhang, Ping Yang, Xiangyun Yu, Aihong Zhang, Jie Xu, Xiaoyu Li, Zhanjiang |
author_facet | Jiang, Molin Zhang, Ping Yang, Xiangyun Yu, Aihong Zhang, Jie Xu, Xiaoyu Li, Zhanjiang |
author_sort | Jiang, Molin |
collection | PubMed |
description | Panic disorder (PD) is an anxiety disorder that impairs life quality and social function and is associated with distributed brain regions. However, the alteration of the structural network remains unclear in PD patients. This study explored the specific characteristics of the structural brain network in patients with PD by graph theory analysis of diffusion tensor images (DTI). A total of 81 PD patients and 48 matched healthy controls were recruited for this study. The structural networks were constructed, and the network topological properties for individuals were estimated. At the global level, the network efficiency was higher, while the shortest path length and clustering coefficient were lower in the PD group compared to the healthy control (HC) group. At the nodal level, the PD group showed a widespread higher nodal efficiency and lower average shortest path length in the prefrontal, sensorimotor, limbic, insula, and cerebellum regions. Overall, the current results showed that the alteration of information processing in the fear network might play a role in the pathophysiology of PD. |
format | Online Article Text |
id | pubmed-9964494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99644942023-02-26 Altered White Matter Network Topology in Panic Disorder Jiang, Molin Zhang, Ping Yang, Xiangyun Yu, Aihong Zhang, Jie Xu, Xiaoyu Li, Zhanjiang J Pers Med Article Panic disorder (PD) is an anxiety disorder that impairs life quality and social function and is associated with distributed brain regions. However, the alteration of the structural network remains unclear in PD patients. This study explored the specific characteristics of the structural brain network in patients with PD by graph theory analysis of diffusion tensor images (DTI). A total of 81 PD patients and 48 matched healthy controls were recruited for this study. The structural networks were constructed, and the network topological properties for individuals were estimated. At the global level, the network efficiency was higher, while the shortest path length and clustering coefficient were lower in the PD group compared to the healthy control (HC) group. At the nodal level, the PD group showed a widespread higher nodal efficiency and lower average shortest path length in the prefrontal, sensorimotor, limbic, insula, and cerebellum regions. Overall, the current results showed that the alteration of information processing in the fear network might play a role in the pathophysiology of PD. MDPI 2023-01-27 /pmc/articles/PMC9964494/ /pubmed/36836461 http://dx.doi.org/10.3390/jpm13020227 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Jiang, Molin Zhang, Ping Yang, Xiangyun Yu, Aihong Zhang, Jie Xu, Xiaoyu Li, Zhanjiang Altered White Matter Network Topology in Panic Disorder |
title | Altered White Matter Network Topology in Panic Disorder |
title_full | Altered White Matter Network Topology in Panic Disorder |
title_fullStr | Altered White Matter Network Topology in Panic Disorder |
title_full_unstemmed | Altered White Matter Network Topology in Panic Disorder |
title_short | Altered White Matter Network Topology in Panic Disorder |
title_sort | altered white matter network topology in panic disorder |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964494/ https://www.ncbi.nlm.nih.gov/pubmed/36836461 http://dx.doi.org/10.3390/jpm13020227 |
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