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Mechanisms of Transmission and Processing of Pain: A Narrative Review
Knowledge about the mechanisms of transmission and the processing of nociceptive information, both in healthy and pathological states, has greatly expanded in recent years. This rapid progress is due to a multidisciplinary approach involving the simultaneous use of different branches of study, such...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964506/ https://www.ncbi.nlm.nih.gov/pubmed/36833753 http://dx.doi.org/10.3390/ijerph20043064 |
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author | Di Maio, Girolamo Villano, Ines Ilardi, Ciro Rosario Messina, Antonietta Monda, Vincenzo Iodice, Ashlei Clara Porro, Chiara Panaro, Maria Antonietta Chieffi, Sergio Messina, Giovanni Monda, Marcellino La Marra, Marco |
author_facet | Di Maio, Girolamo Villano, Ines Ilardi, Ciro Rosario Messina, Antonietta Monda, Vincenzo Iodice, Ashlei Clara Porro, Chiara Panaro, Maria Antonietta Chieffi, Sergio Messina, Giovanni Monda, Marcellino La Marra, Marco |
author_sort | Di Maio, Girolamo |
collection | PubMed |
description | Knowledge about the mechanisms of transmission and the processing of nociceptive information, both in healthy and pathological states, has greatly expanded in recent years. This rapid progress is due to a multidisciplinary approach involving the simultaneous use of different branches of study, such as systems neurobiology, behavioral analysis, genetics, and cell and molecular techniques. This narrative review aims to clarify the mechanisms of transmission and the processing of pain while also taking into account the characteristics and properties of nociceptors and how the immune system influences pain perception. Moreover, several important aspects of this crucial theme of human life will be discussed. Nociceptor neurons and the immune system play a key role in pain and inflammation. The interactions between the immune system and nociceptors occur within peripheral sites of injury and the central nervous system. The modulation of nociceptor activity or chemical mediators may provide promising novel approaches to the treatment of pain and chronic inflammatory disease. The sensory nervous system is fundamental in the modulation of the host’s protective response, and understanding its interactions is pivotal in the process of revealing new strategies for the treatment of pain. |
format | Online Article Text |
id | pubmed-9964506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99645062023-02-26 Mechanisms of Transmission and Processing of Pain: A Narrative Review Di Maio, Girolamo Villano, Ines Ilardi, Ciro Rosario Messina, Antonietta Monda, Vincenzo Iodice, Ashlei Clara Porro, Chiara Panaro, Maria Antonietta Chieffi, Sergio Messina, Giovanni Monda, Marcellino La Marra, Marco Int J Environ Res Public Health Review Knowledge about the mechanisms of transmission and the processing of nociceptive information, both in healthy and pathological states, has greatly expanded in recent years. This rapid progress is due to a multidisciplinary approach involving the simultaneous use of different branches of study, such as systems neurobiology, behavioral analysis, genetics, and cell and molecular techniques. This narrative review aims to clarify the mechanisms of transmission and the processing of pain while also taking into account the characteristics and properties of nociceptors and how the immune system influences pain perception. Moreover, several important aspects of this crucial theme of human life will be discussed. Nociceptor neurons and the immune system play a key role in pain and inflammation. The interactions between the immune system and nociceptors occur within peripheral sites of injury and the central nervous system. The modulation of nociceptor activity or chemical mediators may provide promising novel approaches to the treatment of pain and chronic inflammatory disease. The sensory nervous system is fundamental in the modulation of the host’s protective response, and understanding its interactions is pivotal in the process of revealing new strategies for the treatment of pain. MDPI 2023-02-09 /pmc/articles/PMC9964506/ /pubmed/36833753 http://dx.doi.org/10.3390/ijerph20043064 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Di Maio, Girolamo Villano, Ines Ilardi, Ciro Rosario Messina, Antonietta Monda, Vincenzo Iodice, Ashlei Clara Porro, Chiara Panaro, Maria Antonietta Chieffi, Sergio Messina, Giovanni Monda, Marcellino La Marra, Marco Mechanisms of Transmission and Processing of Pain: A Narrative Review |
title | Mechanisms of Transmission and Processing of Pain: A Narrative Review |
title_full | Mechanisms of Transmission and Processing of Pain: A Narrative Review |
title_fullStr | Mechanisms of Transmission and Processing of Pain: A Narrative Review |
title_full_unstemmed | Mechanisms of Transmission and Processing of Pain: A Narrative Review |
title_short | Mechanisms of Transmission and Processing of Pain: A Narrative Review |
title_sort | mechanisms of transmission and processing of pain: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964506/ https://www.ncbi.nlm.nih.gov/pubmed/36833753 http://dx.doi.org/10.3390/ijerph20043064 |
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