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Myositis Autoantibodies in Patients with Suspected Post-Treatment Lyme Disease Syndrome

Most patients suffering from Lyme disease are effectively treated with antibiotics. In some patients, however, problems persist for a long time despite appropriate therapy. The term post-treatment Lyme disease syndrome (PTLDS) is currently used for this condition in scientific literature. The pathog...

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Autores principales: Sloupenska, Kristyna, Koubkova, Barbora, Horak, Pavel, Hutyrova, Beata, Racansky, Mojmir, Mares, Jan, Miklusova, Martina, Schovanek, Jan, Zapletalova, Jana, Raska, Milan, Krupka, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964525/
https://www.ncbi.nlm.nih.gov/pubmed/36836887
http://dx.doi.org/10.3390/life13020527
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author Sloupenska, Kristyna
Koubkova, Barbora
Horak, Pavel
Hutyrova, Beata
Racansky, Mojmir
Mares, Jan
Miklusova, Martina
Schovanek, Jan
Zapletalova, Jana
Raska, Milan
Krupka, Michal
author_facet Sloupenska, Kristyna
Koubkova, Barbora
Horak, Pavel
Hutyrova, Beata
Racansky, Mojmir
Mares, Jan
Miklusova, Martina
Schovanek, Jan
Zapletalova, Jana
Raska, Milan
Krupka, Michal
author_sort Sloupenska, Kristyna
collection PubMed
description Most patients suffering from Lyme disease are effectively treated with antibiotics. In some patients, however, problems persist for a long time despite appropriate therapy. The term post-treatment Lyme disease syndrome (PTLDS) is currently used for this condition in scientific literature. The pathogenesis is still not precisely known, but the involvement of immunopathological mechanisms is assumed. In our study, we analyzed the presence of autoantibodies including myositis-specific (MSA) and myositis-associated autoantibodies (MAA) in patients with laboratory proven history of Lyme disease and with clinical symptoms of PTLDS. A total of 59 patients meeting the criteria for PTLDS were enrolled in this study. The control group consisted of 40 patients undergoing differential diagnosis of neurological disorders without clinical and/or laboratory-proven history of Lyme disease. The presence of autoantibodies was determined by immunoblot methods and positive samples were further tested for serum creatine kinase (CK) and myoglobin levels. The presence of myositis autoantibodies was detected in 18 subjects with suspected PTLDS (30.5%), but only in 5% of control subjects exhibiting no evidence of Lyme disease history. The difference was statistically significant (p = 0.002). The subsequent biochemical analysis of muscle-damage markers in positive subjects found a mild elevation in six MSA/MAA-positive PTLDS patients. The study detected raised MSA/MAA autoantibodies formation in the group of PTLDS patients raising the question about their involvement in the pathogenesis of this syndrome.
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spelling pubmed-99645252023-02-26 Myositis Autoantibodies in Patients with Suspected Post-Treatment Lyme Disease Syndrome Sloupenska, Kristyna Koubkova, Barbora Horak, Pavel Hutyrova, Beata Racansky, Mojmir Mares, Jan Miklusova, Martina Schovanek, Jan Zapletalova, Jana Raska, Milan Krupka, Michal Life (Basel) Communication Most patients suffering from Lyme disease are effectively treated with antibiotics. In some patients, however, problems persist for a long time despite appropriate therapy. The term post-treatment Lyme disease syndrome (PTLDS) is currently used for this condition in scientific literature. The pathogenesis is still not precisely known, but the involvement of immunopathological mechanisms is assumed. In our study, we analyzed the presence of autoantibodies including myositis-specific (MSA) and myositis-associated autoantibodies (MAA) in patients with laboratory proven history of Lyme disease and with clinical symptoms of PTLDS. A total of 59 patients meeting the criteria for PTLDS were enrolled in this study. The control group consisted of 40 patients undergoing differential diagnosis of neurological disorders without clinical and/or laboratory-proven history of Lyme disease. The presence of autoantibodies was determined by immunoblot methods and positive samples were further tested for serum creatine kinase (CK) and myoglobin levels. The presence of myositis autoantibodies was detected in 18 subjects with suspected PTLDS (30.5%), but only in 5% of control subjects exhibiting no evidence of Lyme disease history. The difference was statistically significant (p = 0.002). The subsequent biochemical analysis of muscle-damage markers in positive subjects found a mild elevation in six MSA/MAA-positive PTLDS patients. The study detected raised MSA/MAA autoantibodies formation in the group of PTLDS patients raising the question about their involvement in the pathogenesis of this syndrome. MDPI 2023-02-15 /pmc/articles/PMC9964525/ /pubmed/36836887 http://dx.doi.org/10.3390/life13020527 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Sloupenska, Kristyna
Koubkova, Barbora
Horak, Pavel
Hutyrova, Beata
Racansky, Mojmir
Mares, Jan
Miklusova, Martina
Schovanek, Jan
Zapletalova, Jana
Raska, Milan
Krupka, Michal
Myositis Autoantibodies in Patients with Suspected Post-Treatment Lyme Disease Syndrome
title Myositis Autoantibodies in Patients with Suspected Post-Treatment Lyme Disease Syndrome
title_full Myositis Autoantibodies in Patients with Suspected Post-Treatment Lyme Disease Syndrome
title_fullStr Myositis Autoantibodies in Patients with Suspected Post-Treatment Lyme Disease Syndrome
title_full_unstemmed Myositis Autoantibodies in Patients with Suspected Post-Treatment Lyme Disease Syndrome
title_short Myositis Autoantibodies in Patients with Suspected Post-Treatment Lyme Disease Syndrome
title_sort myositis autoantibodies in patients with suspected post-treatment lyme disease syndrome
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964525/
https://www.ncbi.nlm.nih.gov/pubmed/36836887
http://dx.doi.org/10.3390/life13020527
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