Cargando…

SARS-CoV-2 Nsp2 Contributes to Inflammation by Activating NF-κB

COVID-19 is associated with robust inflammation and partially impaired antiviral responses. The modulation of inflammatory gene expression by SARS-CoV-2 is not completely understood. In this study, we characterized the inflammatory and antiviral responses mounted during SARS-CoV-2 infection. K18-hAC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lacasse, Émile, Gudimard, Leslie, Dubuc, Isabelle, Gravel, Annie, Allaeys, Isabelle, Boilard, Éric, Flamand, Louis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964531/ https://www.ncbi.nlm.nih.gov/pubmed/36851549 http://dx.doi.org/10.3390/v15020334

Ejemplares similares

Cytokines and Lipid Mediators of Inflammation in Lungs of SARS-CoV-2 Infected Mice
por: Dubuc, Isabelle, et al.
Publicado: (2022)

Platelet activation by SARS-CoV-2 implicates the release of active tissue factor by infected cells
por: Puhm, Florian, et al.
Publicado: (2022)

Chemokines and eicosanoids fuel the hyperinflammation within the lungs of patients with severe COVID-19
por: Zaid, Younes, et al.
Publicado: (2021)

Live imaging of platelets and neutrophils during antibody-mediated neurovascular thrombosis
por: Laroche, Audree, et al.
Publicado: (2022)

Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins
por: Trempe, Frédéric, et al.
Publicado: (2015)

SARS-CoV-2 Nsp14 protein associates with IMPDH2 and activates NF-κB signaling
por: Li, Tai-Wei, et al.
Publicado: (2022)

SARS-CoV-2 Nsp5 Activates NF-κB Pathway by Upregulating SUMOylation of MAVS
por: Li, Weiling, et al.
Publicado: (2021)

SARS-CoV-2 Nsp14 activates NF-κB signaling and induces IL-8 upregulation
por: Li, Taiwei, et al.
Publicado: (2021)

Ubiquitination of SARS-CoV-2 NSP6 and ORF7a Facilitates NF-κB Activation
por: Nishitsuji, Hironori, et al.
Publicado: (2022)

Frequency of Chromosomally-Integrated Human Herpesvirus 6 in Children with Acute Lymphoblastic Leukemia
por: Gravel, Annie, et al.
Publicado: (2013)

Complete Genome Sequence of Early Passaged Human Herpesvirus 6A (GS Strain) Isolated from North America
por: Gravel, Annie, et al.
Publicado: (2013)

Platelets Can Associate With SARS-CoV-2 RNA and Are Hyperactivated in COVID-19
por: Zaid, Younes, et al.
Publicado: (2020)

Inherited Chromosomally Integrated Human Herpesvirus 6 Demonstrates Tissue-Specific RNA Expression In Vivo That Correlates with an Increased Antibody Immune Response
por: Peddu, Vikas, et al.
Publicado: (2019)

The interaction of secreted phospholipase A(2)-IIA with the microbiota alters its lipidome and promotes inflammation
por: Doré, Etienne, et al.
Publicado: (2022)

Crystallization and diffraction analysis of the SARS coronavirus nsp10–nsp16 complex
por: Debarnot, Claire, et al.
Publicado: (2011)

High levels of eicosanoids and docosanoids in the lungs of intubated COVID‐19 patients
por: Archambault, Anne‐Sophie, et al.
Publicado: (2021)

The Promyelocytic Leukemia Protein facilitates human herpesvirus 6B chromosomal integration, immediate-early 1 protein multiSUMOylation and its localization at telomeres
por: Collin, Vanessa, et al.
Publicado: (2020)

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication
por: Wilamowski, Mateusz, et al.
Publicado: (2021)

Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of Cis-Activity for Replication and a Link of nsp2 to Inflammation Induction
por: Zhou, Shaochuan, et al.
Publicado: (2019)

Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A
por: Saviola, Anthony J., et al.
Publicado: (2019)

Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 Methyltransferase
por: Benoni, Roberto, et al.
Publicado: (2021)

Scalable Inhibitors of the Nsp3–Nsp4 Coupling in SARS-CoV-2
por: Azizogli, Abdul-Rahman, et al.
Publicado: (2023)

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
por: Yuen, Chun-Kit, et al.
Publicado: (2020)

Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2′-O-Methyltransferase nsp10/nsp16 Complex
por: Decroly, Etienne, et al.
Publicado: (2011)

Porcine transmissible gastroenteritis virus nonstructural protein 2 contributes to inflammation via NF-κB activation
por: Wang, Li, et al.
Publicado: (2018)

Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2
por: Peng, Qi, et al.
Publicado: (2020)

Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16
por: Kozielski, Frank, et al.
Publicado: (2021)

Mapping the Human Herpesvirus 6B Transcriptome
por: Gravel, Annie, et al.
Publicado: (2021)

Role for the shelterin protein TRF2 in human herpesvirus 6A/B chromosomal integration
por: Gilbert-Girard, Shella, et al.
Publicado: (2020)

Predicted coronavirus Nsp5 protease cleavage sites in the human proteome
por: Scott, Benjamin M., et al.
Publicado: (2022)

NF-κB signaling in inflammation
por: Liu, Ting, et al.
Publicado: (2017)

NF-κB and Nrf2 signaling pathways contribute to wogonin-mediated inhibition of inflammation-associated colorectal carcinogenesis
por: Yao, J, et al.
Publicado: (2014)

Transcription factors Nrf2 and NF-κB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice
por: Meng, Qing-Tao, et al.
Publicado: (2017)

Nutrient regulation of lipochitooligosaccharide recognition in plants via NSP1 and NSP2
por: Li, Xin-Ran, et al.
Publicado: (2022)

Multi-targeting approach for nsp3, nsp9, nsp12 and nsp15 proteins of SARS-CoV-2 by Diosmin as illustrated by molecular docking and molecular dynamics simulation methodologies
por: Kumar, Sumit, et al.
Publicado: (2021)

Identification of novel mutations in the methyltransferase complex (Nsp10-Nsp16) of SARS-CoV-2
por: Azad, Gajendra Kumar
Publicado: (2020)

Presence of diabetes autoantigens in extracellular vesicles derived from human islets
por: Hasilo, Craig P., et al.
Publicado: (2017)

Comparison of Binding Site of Remdesivir and Its Metabolites with NSP12-NSP7-NSP8, and NSP3 of SARS CoV-2 Virus and Alternative Potential Drugs for COVID-19 Treatment
por: Jung, Lindsey S, et al.
Publicado: (2020)

The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine
por: Rosas-Lemus, Monica, et al.
Publicado: (2020)

NF-κB in inflammation and renal diseases
por: Zhang, Haisong, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_d3brqg3k6jcrdusbrbq7rcc8i0