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Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study

Non-motor symptoms (NMS) characterize the Parkinson’s disease (PD) clinical picture, and as well as motor fluctuations, PD patients can also experience NMS fluctuations (NMF). The aim of this observational study was to investigate the presence of NMS and NMF in patients with PD using the recently va...

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Autores principales: Carpi, Matteo, Pierantozzi, Mariangela, Cofano, Stefano, Fernandes, Mariana, Cerroni, Rocco, De Cillis, Francesca, Mercuri, Nicola Biagio, Stefani, Alessandro, Liguori, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964567/
https://www.ncbi.nlm.nih.gov/pubmed/36836476
http://dx.doi.org/10.3390/jpm13020242
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author Carpi, Matteo
Pierantozzi, Mariangela
Cofano, Stefano
Fernandes, Mariana
Cerroni, Rocco
De Cillis, Francesca
Mercuri, Nicola Biagio
Stefani, Alessandro
Liguori, Claudio
author_facet Carpi, Matteo
Pierantozzi, Mariangela
Cofano, Stefano
Fernandes, Mariana
Cerroni, Rocco
De Cillis, Francesca
Mercuri, Nicola Biagio
Stefani, Alessandro
Liguori, Claudio
author_sort Carpi, Matteo
collection PubMed
description Non-motor symptoms (NMS) characterize the Parkinson’s disease (PD) clinical picture, and as well as motor fluctuations, PD patients can also experience NMS fluctuations (NMF). The aim of this observational study was to investigate the presence of NMS and NMF in patients with PD using the recently validated Non-Motor Fluctuation Assessment questionnaire (NoMoFa) and to evaluate their associations with disease characteristics and motor impairment. Patients with PD were consecutively recruited, and NMS, NMF, motor impairment, motor fluctuations, levodopa-equivalent daily dose, and motor performance were evaluated. One-third of the 25 patients included in the study (10 females, 15 males, mean age: 69.9 ± 10.3) showed NMF, and patients with NMF presented a higher number of NMS (p < 0.01). Static NMS and NoMoFa total score were positively associated with motor performance assessed with the Global Mobility Task (p < 0.01 and p < 0.001), and the latter was also correlated with motor impairment (p < 0.05) but not with motor fluctuations. Overall, this study shows evidence that NMF are frequently reported by mild-to-moderate PD patients and associated with an increased number of NMS. The relationship between NoMoFa total score and motor functioning highlights the importance of understanding the clinical role of NMS and NMF in the management of PD patients.
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spelling pubmed-99645672023-02-26 Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study Carpi, Matteo Pierantozzi, Mariangela Cofano, Stefano Fernandes, Mariana Cerroni, Rocco De Cillis, Francesca Mercuri, Nicola Biagio Stefani, Alessandro Liguori, Claudio J Pers Med Article Non-motor symptoms (NMS) characterize the Parkinson’s disease (PD) clinical picture, and as well as motor fluctuations, PD patients can also experience NMS fluctuations (NMF). The aim of this observational study was to investigate the presence of NMS and NMF in patients with PD using the recently validated Non-Motor Fluctuation Assessment questionnaire (NoMoFa) and to evaluate their associations with disease characteristics and motor impairment. Patients with PD were consecutively recruited, and NMS, NMF, motor impairment, motor fluctuations, levodopa-equivalent daily dose, and motor performance were evaluated. One-third of the 25 patients included in the study (10 females, 15 males, mean age: 69.9 ± 10.3) showed NMF, and patients with NMF presented a higher number of NMS (p < 0.01). Static NMS and NoMoFa total score were positively associated with motor performance assessed with the Global Mobility Task (p < 0.01 and p < 0.001), and the latter was also correlated with motor impairment (p < 0.05) but not with motor fluctuations. Overall, this study shows evidence that NMF are frequently reported by mild-to-moderate PD patients and associated with an increased number of NMS. The relationship between NoMoFa total score and motor functioning highlights the importance of understanding the clinical role of NMS and NMF in the management of PD patients. MDPI 2023-01-29 /pmc/articles/PMC9964567/ /pubmed/36836476 http://dx.doi.org/10.3390/jpm13020242 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Carpi, Matteo
Pierantozzi, Mariangela
Cofano, Stefano
Fernandes, Mariana
Cerroni, Rocco
De Cillis, Francesca
Mercuri, Nicola Biagio
Stefani, Alessandro
Liguori, Claudio
Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study
title Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study
title_full Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study
title_fullStr Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study
title_full_unstemmed Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study
title_short Both Motor and Non-Motor Fluctuations Matter in the Clinical Management of Patients with Parkinson’s Disease: An Exploratory Study
title_sort both motor and non-motor fluctuations matter in the clinical management of patients with parkinson’s disease: an exploratory study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964567/
https://www.ncbi.nlm.nih.gov/pubmed/36836476
http://dx.doi.org/10.3390/jpm13020242
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