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The Role of Microsphere Structures in Bottom-Up Bone Tissue Engineering

Bone defects have caused immense healthcare concerns and economic burdens throughout the world. Traditional autologous allogeneic bone grafts have many drawbacks, so the emergence of bone tissue engineering brings new hope. Bone tissue engineering is an interdisciplinary biomedical engineering metho...

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Detalles Bibliográficos
Autores principales: Feng, Ziyi, Su, Xin, Wang, Ting, Sun, Xiaoting, Yang, Huazhe, Guo, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964570/
https://www.ncbi.nlm.nih.gov/pubmed/36839645
http://dx.doi.org/10.3390/pharmaceutics15020321
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author Feng, Ziyi
Su, Xin
Wang, Ting
Sun, Xiaoting
Yang, Huazhe
Guo, Shu
author_facet Feng, Ziyi
Su, Xin
Wang, Ting
Sun, Xiaoting
Yang, Huazhe
Guo, Shu
author_sort Feng, Ziyi
collection PubMed
description Bone defects have caused immense healthcare concerns and economic burdens throughout the world. Traditional autologous allogeneic bone grafts have many drawbacks, so the emergence of bone tissue engineering brings new hope. Bone tissue engineering is an interdisciplinary biomedical engineering method that involves scaffold materials, seed cells, and “growth factors”. However, the traditional construction approach is not flexible and is unable to adapt to the specific shape of the defect, causing the cells inside the bone to be unable to receive adequate nourishment. Therefore, a simple but effective solution using the “bottom-up” method is proposed. Microspheres are structures with diameters ranging from 1 to 1000 µm that can be used as supports for cell growth, either in the form of a scaffold or in the form of a drug delivery system. Herein, we address a variety of strategies for the production of microspheres, the classification of raw materials, and drug loading, as well as analyze new strategies for the use of microspheres in bone tissue engineering. We also consider new perspectives and possible directions for future development.
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spelling pubmed-99645702023-02-26 The Role of Microsphere Structures in Bottom-Up Bone Tissue Engineering Feng, Ziyi Su, Xin Wang, Ting Sun, Xiaoting Yang, Huazhe Guo, Shu Pharmaceutics Review Bone defects have caused immense healthcare concerns and economic burdens throughout the world. Traditional autologous allogeneic bone grafts have many drawbacks, so the emergence of bone tissue engineering brings new hope. Bone tissue engineering is an interdisciplinary biomedical engineering method that involves scaffold materials, seed cells, and “growth factors”. However, the traditional construction approach is not flexible and is unable to adapt to the specific shape of the defect, causing the cells inside the bone to be unable to receive adequate nourishment. Therefore, a simple but effective solution using the “bottom-up” method is proposed. Microspheres are structures with diameters ranging from 1 to 1000 µm that can be used as supports for cell growth, either in the form of a scaffold or in the form of a drug delivery system. Herein, we address a variety of strategies for the production of microspheres, the classification of raw materials, and drug loading, as well as analyze new strategies for the use of microspheres in bone tissue engineering. We also consider new perspectives and possible directions for future development. MDPI 2023-01-18 /pmc/articles/PMC9964570/ /pubmed/36839645 http://dx.doi.org/10.3390/pharmaceutics15020321 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Feng, Ziyi
Su, Xin
Wang, Ting
Sun, Xiaoting
Yang, Huazhe
Guo, Shu
The Role of Microsphere Structures in Bottom-Up Bone Tissue Engineering
title The Role of Microsphere Structures in Bottom-Up Bone Tissue Engineering
title_full The Role of Microsphere Structures in Bottom-Up Bone Tissue Engineering
title_fullStr The Role of Microsphere Structures in Bottom-Up Bone Tissue Engineering
title_full_unstemmed The Role of Microsphere Structures in Bottom-Up Bone Tissue Engineering
title_short The Role of Microsphere Structures in Bottom-Up Bone Tissue Engineering
title_sort role of microsphere structures in bottom-up bone tissue engineering
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964570/
https://www.ncbi.nlm.nih.gov/pubmed/36839645
http://dx.doi.org/10.3390/pharmaceutics15020321
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