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Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions

3,n-fused (n = 4–7) tricyclic indoles are pervasive motifs, embedded in a variety of biologically active molecules and natural products. Thus, numerous catalytic methods have been developed for the synthesis of these skeletons over the past few decades. In particular, palladium-catalyzed transformat...

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Detalles Bibliográficos
Autores principales: Fan, Liangxin, Zhu, Xinxin, Liu, Xingyuan, He, Fangyu, Yang, Guoyu, Xu, Cuilian, Yang, Xifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964631/
https://www.ncbi.nlm.nih.gov/pubmed/36838635
http://dx.doi.org/10.3390/molecules28041647
Descripción
Sumario:3,n-fused (n = 4–7) tricyclic indoles are pervasive motifs, embedded in a variety of biologically active molecules and natural products. Thus, numerous catalytic methods have been developed for the synthesis of these skeletons over the past few decades. In particular, palladium-catalyzed transformations have received much attention in recent years. This review summarizes recent developments in the synthesis of these tricyclic indoles with palladium-catalyzed domino reactions and their applications in the total synthesis of representative natural products.