Cargando…
Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions
3,n-fused (n = 4–7) tricyclic indoles are pervasive motifs, embedded in a variety of biologically active molecules and natural products. Thus, numerous catalytic methods have been developed for the synthesis of these skeletons over the past few decades. In particular, palladium-catalyzed transformat...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964631/ https://www.ncbi.nlm.nih.gov/pubmed/36838635 http://dx.doi.org/10.3390/molecules28041647 |
_version_ | 1784896554943905792 |
---|---|
author | Fan, Liangxin Zhu, Xinxin Liu, Xingyuan He, Fangyu Yang, Guoyu Xu, Cuilian Yang, Xifa |
author_facet | Fan, Liangxin Zhu, Xinxin Liu, Xingyuan He, Fangyu Yang, Guoyu Xu, Cuilian Yang, Xifa |
author_sort | Fan, Liangxin |
collection | PubMed |
description | 3,n-fused (n = 4–7) tricyclic indoles are pervasive motifs, embedded in a variety of biologically active molecules and natural products. Thus, numerous catalytic methods have been developed for the synthesis of these skeletons over the past few decades. In particular, palladium-catalyzed transformations have received much attention in recent years. This review summarizes recent developments in the synthesis of these tricyclic indoles with palladium-catalyzed domino reactions and their applications in the total synthesis of representative natural products. |
format | Online Article Text |
id | pubmed-9964631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99646312023-02-26 Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions Fan, Liangxin Zhu, Xinxin Liu, Xingyuan He, Fangyu Yang, Guoyu Xu, Cuilian Yang, Xifa Molecules Review 3,n-fused (n = 4–7) tricyclic indoles are pervasive motifs, embedded in a variety of biologically active molecules and natural products. Thus, numerous catalytic methods have been developed for the synthesis of these skeletons over the past few decades. In particular, palladium-catalyzed transformations have received much attention in recent years. This review summarizes recent developments in the synthesis of these tricyclic indoles with palladium-catalyzed domino reactions and their applications in the total synthesis of representative natural products. MDPI 2023-02-08 /pmc/articles/PMC9964631/ /pubmed/36838635 http://dx.doi.org/10.3390/molecules28041647 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fan, Liangxin Zhu, Xinxin Liu, Xingyuan He, Fangyu Yang, Guoyu Xu, Cuilian Yang, Xifa Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions |
title | Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions |
title_full | Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions |
title_fullStr | Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions |
title_full_unstemmed | Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions |
title_short | Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions |
title_sort | recent advances in the synthesis of 3,n-fused tricyclic indole skeletons via palladium-catalyzed domino reactions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964631/ https://www.ncbi.nlm.nih.gov/pubmed/36838635 http://dx.doi.org/10.3390/molecules28041647 |
work_keys_str_mv | AT fanliangxin recentadvancesinthesynthesisof3nfusedtricyclicindoleskeletonsviapalladiumcatalyzeddominoreactions AT zhuxinxin recentadvancesinthesynthesisof3nfusedtricyclicindoleskeletonsviapalladiumcatalyzeddominoreactions AT liuxingyuan recentadvancesinthesynthesisof3nfusedtricyclicindoleskeletonsviapalladiumcatalyzeddominoreactions AT hefangyu recentadvancesinthesynthesisof3nfusedtricyclicindoleskeletonsviapalladiumcatalyzeddominoreactions AT yangguoyu recentadvancesinthesynthesisof3nfusedtricyclicindoleskeletonsviapalladiumcatalyzeddominoreactions AT xucuilian recentadvancesinthesynthesisof3nfusedtricyclicindoleskeletonsviapalladiumcatalyzeddominoreactions AT yangxifa recentadvancesinthesynthesisof3nfusedtricyclicindoleskeletonsviapalladiumcatalyzeddominoreactions |