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Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions

3,n-fused (n = 4–7) tricyclic indoles are pervasive motifs, embedded in a variety of biologically active molecules and natural products. Thus, numerous catalytic methods have been developed for the synthesis of these skeletons over the past few decades. In particular, palladium-catalyzed transformat...

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Detalles Bibliográficos
Autores principales: Fan, Liangxin, Zhu, Xinxin, Liu, Xingyuan, He, Fangyu, Yang, Guoyu, Xu, Cuilian, Yang, Xifa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964631/
https://www.ncbi.nlm.nih.gov/pubmed/36838635
http://dx.doi.org/10.3390/molecules28041647
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author Fan, Liangxin
Zhu, Xinxin
Liu, Xingyuan
He, Fangyu
Yang, Guoyu
Xu, Cuilian
Yang, Xifa
author_facet Fan, Liangxin
Zhu, Xinxin
Liu, Xingyuan
He, Fangyu
Yang, Guoyu
Xu, Cuilian
Yang, Xifa
author_sort Fan, Liangxin
collection PubMed
description 3,n-fused (n = 4–7) tricyclic indoles are pervasive motifs, embedded in a variety of biologically active molecules and natural products. Thus, numerous catalytic methods have been developed for the synthesis of these skeletons over the past few decades. In particular, palladium-catalyzed transformations have received much attention in recent years. This review summarizes recent developments in the synthesis of these tricyclic indoles with palladium-catalyzed domino reactions and their applications in the total synthesis of representative natural products.
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spelling pubmed-99646312023-02-26 Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions Fan, Liangxin Zhu, Xinxin Liu, Xingyuan He, Fangyu Yang, Guoyu Xu, Cuilian Yang, Xifa Molecules Review 3,n-fused (n = 4–7) tricyclic indoles are pervasive motifs, embedded in a variety of biologically active molecules and natural products. Thus, numerous catalytic methods have been developed for the synthesis of these skeletons over the past few decades. In particular, palladium-catalyzed transformations have received much attention in recent years. This review summarizes recent developments in the synthesis of these tricyclic indoles with palladium-catalyzed domino reactions and their applications in the total synthesis of representative natural products. MDPI 2023-02-08 /pmc/articles/PMC9964631/ /pubmed/36838635 http://dx.doi.org/10.3390/molecules28041647 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fan, Liangxin
Zhu, Xinxin
Liu, Xingyuan
He, Fangyu
Yang, Guoyu
Xu, Cuilian
Yang, Xifa
Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions
title Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions
title_full Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions
title_fullStr Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions
title_full_unstemmed Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions
title_short Recent Advances in the Synthesis of 3,n-Fused Tricyclic Indole Skeletons via Palladium-Catalyzed Domino Reactions
title_sort recent advances in the synthesis of 3,n-fused tricyclic indole skeletons via palladium-catalyzed domino reactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964631/
https://www.ncbi.nlm.nih.gov/pubmed/36838635
http://dx.doi.org/10.3390/molecules28041647
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