Cargando…

Neuroprotective Effect of Methanolic Ajwa Seed Extract on Lipopolysaccharide-Induced Memory Dysfunction and Neuroinflammation: In Vivo, Molecular Docking and Dynamics Studies

Islamic literature has indicated that daily consumption of Ajwa dates heals a variety of chronic diseases and disorders. The current research investigates the neuroprotective effect of methanolic Ajwa seed extract (MASE) on lipopolysaccharide (LPS)-induced cognitive deficits using multiple approache...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mani, Vasudevan, Arfeen, Minhajul, Dhaked, Devendra Kumar, Mohammed, Hamdoon A., Amirthalingam, Palanisamy, Elsisi, Hossam A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964647/ https://www.ncbi.nlm.nih.gov/pubmed/36840284 http://dx.doi.org/10.3390/plants12040934

Ejemplares similares

Levetiracetam Ameliorates Doxorubicin-Induced Chemobrain by Enhancing Cholinergic Transmission and Reducing Neuroinflammation Using an Experimental Rat Model and Molecular Docking Study
por: Mani, Vasudevan, et al.
Publicado: (2022)

Aqueous Ajwa dates seeds extract improves memory impairment in type-2 diabetes mellitus rats by reducing blood glucose levels and enhancing brain cholinergic transmission
por: Mani, Vasudevan, et al.
Publicado: (2022)

Sukkari dates seed improves type-2 diabetes mellitus-induced memory impairment by reducing blood glucose levels and enhancing brain cholinergic transmission: In vivo and molecular modeling studies
por: Mani, Vasudevan, et al.
Publicado: (2022)

Neuroprotective Effect of Clobenpropit against Lipopolysaccharide-Induced Cognitive Deficits via Attenuating Neuroinflammation and Enhancing Mitochondrial Functions in Mice
por: Mani, Vasudevan, et al.
Publicado: (2021)

Piracetam as a Therapeutic Agent for Doxorubicin-Induced Cognitive Deficits by Enhancing Cholinergic Functions and Reducing Neuronal Inflammation, Apoptosis, and Oxidative Stress in Rats
por: Mani, Vasudevan, et al.
Publicado: (2022)

Impact of levetiracetam on cognitive impairment, neuroinflammation, oxidative stress, and neuronal apoptosis caused by lipopolysaccharides in rats
por: Mani, Vasudevan, et al.
Publicado: (2023)

Role of Ajwa Date Fruit Pulp and Seed in the Management of Diseases through In Vitro and In Silico Analysis
por: Anwar, Shehwaz, et al.
Publicado: (2022)

Phytochemical analysis and nephroprotective potential of Ajwa date in doxorubicin‐induced nephrotoxicity rats: Biochemical and molecular docking approaches
por: Baothman, Othman A. S., et al.
Publicado: (2023)

Consequences of hydrogenated vegetable fat substitution with Ajwa seed oil on physicochemical and nutritional aspects of functional cookies
por: Raza, Muhammad Qasim, et al.
Publicado: (2020)

Effect of aqueous extract of black pepper and ajwa seed on liver enzymes in alloxan-induced diabetic Wister albino rats
por: Sarfraz, Maliha, et al.
Publicado: (2017)

6-O-angeloylplenolin exerts neuroprotection against lipopolysaccharide-induced neuroinflammation in vitro and in vivo
por: Zhou, Yi-le, et al.
Publicado: (2019)

Neuroprotective Effect of Bcl-2 on Lipopolysaccharide-Induced Neuroinflammation in Cortical Neural Stem Cells
por: Park, Shin-Young, et al.
Publicado: (2022)

Ameliorative Influence of Ajwa Dates on Ochratoxin A-Induced Testis Toxicity
por: Abdu, Suzan Bakr
Publicado: (2018)

Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation to Elucidate the Molecular Targets and Potential Mechanism of Phoenix dactylifera (Ajwa Dates) against Candidiasis
por: Adnan, Mohd, et al.
Publicado: (2023)

In Vitro Antiviral Effect and Potential Neuroprotection of Salvadora persica L. Stem Bark Extract against Lipopolysaccharides-Induced Neuroinflammation in Mice: LC-ESI-MS/MS Analysis of the Methanol Extract
por: Binsuwaidan, Reem, et al.
Publicado: (2023)

Neuroinflammation: The Role of Anthocyanins as Neuroprotectants
por: Banji, Otilia J.F., et al.
Publicado: (2022)

Chronotherapeutic neuroprotective effect of verapamil against lipopolysaccharide-induced neuroinflammation in mice through modulation of calcium-dependent genes
por: Mosalam, Esraa M., et al.
Publicado: (2022)

Discrimination and Nitric Oxide Inhibitory Activity Correlation of Ajwa Dates from Different Grades and Origin
por: Abdul-Hamid, Nur Ashikin, et al.
Publicado: (2016)

Ajwa Nanopreparation Prevents Doxorubicin-Associated Cardiac Dysfunction: Effect on Cardiac Ischemia and Antioxidant Capacity
por: Al-Jaouni, Soad, et al.
Publicado: (2019)

Protective effects of Ajwa date extract against tissue damage induced by acute diclofenac toxicity
por: Aljuhani, Naif, et al.
Publicado: (2019)

Anti-inflammatory and antibacterial potential of Ajwa date (Phoenix dactylifera L.) extract in burn infection
por: Mauludiyana, Septin, et al.
Publicado: (2023)

Role of Natural Antioxidants on Neuroprotection and Neuroinflammation
por: Nuzzo, Domenico
Publicado: (2021)

Insights from molecular docking and molecular dynamics on the potential of vitexin as an antagonist candidate against lipopolysaccharide (LPS) for microglial activation in neuroinflammation
por: Yahaya, M. A. F., et al.
Publicado: (2021)

Inhibitory Effects of Myricetin on Lipopolysaccharide-Induced Neuroinflammation
por: Jang, Jung-Hee, et al.
Publicado: (2020)

Neuroprotective potential of isothiocyanates in an in vitro model of neuroinflammation
por: Latronico, Tiziana, et al.
Publicado: (2020)

Hemp (Cannabis sativa L.) Seed Phenylpropionamides Composition and Effects on Memory Dysfunction and Biomarkers of Neuroinflammation Induced by Lipopolysaccharide in Mice
por: Zhou, Yuefang, et al.
Publicado: (2018)

Anti-cancer effects of Ajwa dates (Phoenix dactylifera L.) in diethylnitrosamine induced hepatocellular carcinoma in Wistar rats
por: Khan, Fazal, et al.
Publicado: (2017)

Effect of Ajwa Dates Consumption to Inhibit the Progression of Preeclampsia Threats on Mean Arterial Pressure and Roll-Over Test
por: Royani, Ida, et al.
Publicado: (2019)

Quetiapine Moderates Doxorubicin-Induced Cognitive Deficits: Influence of Oxidative Stress, Neuroinflammation, and Cellular Apoptosis
por: Mani, Vasudevan, et al.
Publicado: (2023)

Prolonged Neuroinflammation after Lipopolysaccharide Exposure in Aged Rats
por: Fu, Hui Qun, et al.
Publicado: (2014)

Rapamycin inhibits lipopolysaccharide-induced neuroinflammation in vitro and in vivo
por: Mengke, Na-Shun, et al.
Publicado: (2016)

Glucocorticoid Induced Leucine Zipper in Lipopolysaccharide Induced Neuroinflammation
por: Witek, Emily, et al.
Publicado: (2019)

Lipopolysaccharide-Induced Neuroinflammation as a Bridge to Understand Neurodegeneration
por: Batista, Carla Ribeiro Alvares, et al.
Publicado: (2019)

Neuroinflammation induced by lipopolysaccharide causes cognitive impairment in mice
por: Zhao, Jiayi, et al.
Publicado: (2019)

Neuroprotective and Immunomodulatory Action of the Endocannabinoid System under Neuroinflammation
por: Kasatkina, Ludmila A., et al.
Publicado: (2021)

Cytostatic and Anti-tumor Potential of Ajwa Date Pulp against Human Hepatocellular Carcinoma HepG2 Cells
por: Siddiqui, Sahabjada, et al.
Publicado: (2019)

Cytotoxic and Antioxidant Effects of Phoenix dactylifera L. (Ajwa Date Extract) on Oral Squamous Cell Carcinoma Cell Line
por: Shahbaz, Khushboo, et al.
Publicado: (2022)

Heavy Metal Ions Removal from Aqueous Solutions by Treated Ajwa Date Pits: Kinetic, Isotherm, and Thermodynamic Approach
por: Azam, Mohammad, et al.
Publicado: (2022)

The Preventive and Therapeutic Effects of Ajwa Date Fruit Extract Against Acute Diclofenac Toxicity-Induced Colopathy: An Experimental Study
por: Hassan, Shaimaa Mohamed Abdelfattah, et al.
Publicado: (2022)

Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment
por: Vasconcelos, Andrea R, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_apj6hr5utikugiaq4ouvesgm5g