Cargando…

Molecular and Biological Investigation of Isolated Marine Fungal Metabolites as Anticancer Agents: A Multi-Target Approach

Cancer is the leading cause of death globally, with an increasing number of cases being annually reported. Nature-derived metabolites have been widely studied for their potential programmed necrosis, cytotoxicity, and anti-proliferation leading to enrichment for the modern medicine, particularly wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bogari, Hanin A., Elhady, Sameh S., Darwish, Khaled M., Refaey, Mohamed S., Mohamed, Radi A., Abdelhameed, Reda F. A., Almalki, Ahmad J., Aldurdunji, Mohammed M., Lashkar, Manar O., Alshehri, Samah O., Malatani, Rania T., Yamada, Koji, Khedr, Amgad I. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964656/ https://www.ncbi.nlm.nih.gov/pubmed/36837781 http://dx.doi.org/10.3390/metabo13020162

Ejemplares similares

Molecular Docking and Dynamics Simulation Study of Hyrtios erectus Isolated Scalarane Sesterterpenes as Potential SARS-CoV-2 Dual Target Inhibitors
por: Elhady, Sameh S., et al.
Publicado: (2021)

LAMA-1: A Cerebroside Isolated from the Deep-Sea-Derived Fungus Penicillium chrysogenum (†)
por: Alshehri, Samah O., et al.
Publicado: (2020)

Meleagrin Isolated from the Red Sea Fungus Penicillium chrysogenum Protects against Bleomycin-Induced Pulmonary Fibrosis in Mice
por: Elhady, Sameh S., et al.
Publicado: (2022)

Metabolic Profiling, Chemical Composition, Antioxidant Capacity, and In Vivo Hepato- and Nephroprotective Effects of Sonchus cornutus in Mice Exposed to Cisplatin
por: Elhady, Sameh S., et al.
Publicado: (2022)

Integration of immunoinformatics and cheminformatics to design and evaluate a multitope vaccine against Klebsiella pneumoniae and Pseudomonas aeruginosa coinfection
por: Gouda, Ahmed M., et al.
Publicado: (2023)

Phragmanthera austroarabica A.G.Mill. and J.A.Nyberg Triggers Apoptosis in MDA-MB-231 Cells In Vitro and In Vivo Assays: Simultaneous Determination of Selected Constituents
por: Goda, Marwa S., et al.
Publicado: (2022)

Production of a New Cyclic Depsipeptide by the Culture Broth of Staphylococcus sp. Isolated from Corallina officinalis L.
por: Abdelhameed, Reda F. A., et al.
Publicado: (2019)

In Vitro Anti-Inflammatory Activity of Cotula anthemoides Essential Oil and In Silico Molecular Docking of Its Bioactives
por: Refaey, Mohamed S., et al.
Publicado: (2022)

Evaluation of The Antioxidant, Antimicrobial, and Anticancer Activities of Dicliptera bupleuroides Isolated Compounds Using In Vitro and In Silico Studies
por: Akbar, Shehla, et al.
Publicado: (2021)

Euclea divinorum Hiern: Chemical Profiling of the Leaf Extract and Its Antioxidant Activity In Silico, In Vitro and in Caenorhabditis elegans Model
por: Bogari, Hanin A., et al.
Publicado: (2022)

Citrus reticulata Leaves Essential Oil as an Antiaging Agent: A Comparative Study between Different Cultivars and Correlation with Their Chemical Compositions
por: Fahmy, Nouran M., et al.
Publicado: (2022)

Deciphering Molecular Aspects of Potential α-Glucosidase Inhibitors within Aspergillus terreus: A Computational Odyssey of Molecular Docking-Coupled Dynamics Simulations and Pharmacokinetic Profiling
por: Elhady, Sameh S., et al.
Publicado: (2023)

Metabolomics-Based Profiling of Clerodendrum speciosum (Lamiaceae) Leaves Using LC/ESI/MS-MS and In Vivo Evaluation of Its Antioxidant Activity Using Caenorhabditis elegans Model
por: Youssef, Fadia S., et al.
Publicado: (2022)

FTIR Characterization of Sulfated Polysaccharides Obtained from Macrocystis integrifolia Algae and Verification of Their Antiangiogenic and Immunomodulatory Potency In Vitro and In Vivo
por: Soto-Vásquez, Marilú Roxana, et al.
Publicado: (2022)

Evaluation of 2-Thioxoimadazolidin-4-one Derivatives as Potent Anti-Cancer Agents through Apoptosis Induction and Antioxidant Activation: In Vitro and In Vivo Approaches
por: Nafie, Mohamed S., et al.
Publicado: (2021)

Valorization of Pimenta racemosa Essential Oils and Extracts: GC-MS and LC-MS Phytochemical Profiling and Evaluation of Helicobacter pylori Inhibitory Activity
por: Ayoub, Iriny M., et al.
Publicado: (2022)

Repurposing α-Adrenoreceptor Blockers as Promising Anti-Virulence Agents in Gram-Negative Bacteria
por: Almalki, Ahmad J., et al.
Publicado: (2022)

Computational and Biological Evaluation of β-Adrenoreceptor Blockers as Promising Bacterial Anti-Virulence Agents
por: Almalki, Ahmad J., et al.
Publicado: (2022)

Metabolic Profiling of Heliotropium crispum Aerial Parts Using HPLC and FTIR and In Vivo Evaluation of Its Anti-Ulcer Activity Using an Ethanol Induced Acute Gastric Ulcer Model
por: Fatima, Syeda Farheen, et al.
Publicado: (2022)

Exploring the Synergistic Effect of Bergamot Essential Oil with Spironolactone Loaded Nano-Phytosomes for Treatment of Acne Vulgaris: In Vitro Optimization, In Silico Studies, and Clinical Evaluation
por: Albash, Rofida, et al.
Publicado: (2023)

Comparative Assessment of the Antioxidant and Anticancer Activities of Plicosepalus acacia and Plicosepalus curviflorus: Metabolomic Profiling and In Silico Studies
por: Eltamany, Enas E., et al.
Publicado: (2022)

Antioxidant and Anti-Inflammatory Activity of Cynanchum acutum L. Isolated Flavonoids Using Experimentally Induced Type 2 Diabetes Mellitus: Biological and In Silico Investigation for NF-κB Pathway/miR-146a Expression Modulation
por: Abdelhameed, Reda F. A., et al.
Publicado: (2021)

VEGFR-Mediated Cytotoxic Activity of Pulicaria undulata Isolated Metabolites: A Biological Evaluation and In Silico Study
por: Elhady, Sameh S., et al.
Publicado: (2021)

New Multi-Targeted Antiproliferative Agents: Design and Synthesis of IC261-Based Oxindoles as Potential Tubulin, CK1 and EGFR Inhibitors
por: Fareed, Momen R., et al.
Publicado: (2021)

Evaluation of the Local Anesthetic Activity, Acute Toxicity, and Structure–Toxicity Relationship in Series of Synthesized 1-Aryltetrahydroisoquinoline Alkaloid Derivatives In Vivo and In Silico
por: Azamatov, Azizbek A., et al.
Publicado: (2023)

Comparative Estimation of the Cytotoxic Activity of Different Parts of Cynara scolymus L.: Crude Extracts versus Green Synthesized Silver Nanoparticles with Apoptotic Investigation
por: Khedr, Amgad I. M., et al.
Publicado: (2022)

Silver Nanoparticles Formulation of Flower Head’s Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation
por: Khedr, Amgad I. M., et al.
Publicado: (2022)

In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR-2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity
por: Elmaaty, Ayman Abo, et al.
Publicado: (2021)

New Antiproliferative Triflavanone from Thymelaea hirsuta—Isolation, Structure Elucidation and Molecular Docking Studies
por: Elhady, Sameh S., et al.
Publicado: (2021)

Anticancer Effects of New Ceramides Isolated from the Red Sea Red Algae Hypnea musciformis in a Model of Ehrlich Ascites Carcinoma: LC-HRMS Analysis Profile and Molecular Modeling
por: Elhady, Sameh S., et al.
Publicado: (2022)

Calendulaglycoside A showing potential activity against SARS-CoV-2 main protease: Molecular docking, molecular dynamics, and SAR studies
por: Zaki, Ahmed A., et al.
Publicado: (2021)

Large-Scale Production of Bioactive Terrein by Aspergillus terreus Strain S020 Isolated from the Saudi Coast of the Red Sea
por: Asfour, Hani Z., et al.
Publicado: (2019)

Thonningia sanguinea Extract: Antioxidant and Cytotoxic Activities Supported by Chemical Composition and Molecular Docking Simulations
por: Abdelhameed, Reda F. A., et al.
Publicado: (2021)

Investigating the structure–activity relationship of marine natural polyketides as promising SARS-CoV-2 main protease inhibitors
por: El-Demerdash, Amr, et al.
Publicado: (2021)

Antioxidant Property of the Egyptian Propolis Extract Versus Aluminum Silicate Intoxication on a Rat’s Lung: Histopathological Studies
por: Abu Almaaty, Ali H., et al.
Publicado: (2020)

Carboxymethyl cellulose/sulfur-functionalized Ti-based MOF composite: synthesis, characterization, antimicrobial, antiviral and anticancer potentiality
por: Abdelhameed, Reda M., et al.
Publicado: (2023)

In silico Designing of an Epitope-Based Vaccine Against Common E. coli Pathotypes
por: Soltan, Mohamed A., et al.
Publicado: (2022)

GC-MS/MS Quantification of EGFR Inhibitors, β-Sitosterol, Betulinic Acid, (+) Eriodictyol, (+) Epipinoresinol, and Secoisolariciresinol, in Crude Extract and Ethyl Acetate Fraction of Thonningia sanguinea
por: Elhady, Sameh S., et al.
Publicado: (2022)

Early electrophysiological study variants and their relationship with clinical presentation and outcomes of patients with Guillain-Barré syndrome
por: Khedr, Eman M., et al.
Publicado: (2023)

Design, Molecular Docking, Synthesis, Anticancer and Anti-Hyperglycemic Assessments of Thiazolidine-2,4-diones Bearing Sulfonylthiourea Moieties as Potent VEGFR-2 Inhibitors and PPARγ Agonists
por: Abdelgawad, Mohamed A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vsr3bah616800ik7n6j2n2nl3f