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Local Drug Delivery Strategies towards Wound Healing

A particular biological process known as wound healing is connected to the overall phenomena of growth and tissue regeneration. Several cellular and matrix elements work together to restore the integrity of injured tissue. The goal of the present review paper focused on the physiology of wound heali...

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Detalles Bibliográficos
Autores principales: Tiwari, Ruchi, Pathak, Kamla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964694/
https://www.ncbi.nlm.nih.gov/pubmed/36839956
http://dx.doi.org/10.3390/pharmaceutics15020634
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author Tiwari, Ruchi
Pathak, Kamla
author_facet Tiwari, Ruchi
Pathak, Kamla
author_sort Tiwari, Ruchi
collection PubMed
description A particular biological process known as wound healing is connected to the overall phenomena of growth and tissue regeneration. Several cellular and matrix elements work together to restore the integrity of injured tissue. The goal of the present review paper focused on the physiology of wound healing, medications used to treat wound healing, and local drug delivery systems for possible skin wound therapy. The capacity of the skin to heal a wound is the result of a highly intricate process that involves several different processes, such as vascular response, blood coagulation, fibrin network creation, re-epithelialisation, collagen maturation, and connective tissue remodelling. Wound healing may be controlled with topical antiseptics, topical antibiotics, herbal remedies, and cellular initiators. In order to effectively eradicate infections and shorten the healing process, contemporary antimicrobial treatments that include antibiotics or antiseptics must be investigated. A variety of delivery systems were described, including innovative delivery systems, hydrogels, microspheres, gold and silver nanoparticles, vesicles, emulsifying systems, nanofibres, artificial dressings, three-dimensional printed skin replacements, dendrimers and carbon nanotubes. It may be inferred that enhanced local delivery methods might be used to provide wound healing agents for faster healing of skin wounds.
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spelling pubmed-99646942023-02-26 Local Drug Delivery Strategies towards Wound Healing Tiwari, Ruchi Pathak, Kamla Pharmaceutics Review A particular biological process known as wound healing is connected to the overall phenomena of growth and tissue regeneration. Several cellular and matrix elements work together to restore the integrity of injured tissue. The goal of the present review paper focused on the physiology of wound healing, medications used to treat wound healing, and local drug delivery systems for possible skin wound therapy. The capacity of the skin to heal a wound is the result of a highly intricate process that involves several different processes, such as vascular response, blood coagulation, fibrin network creation, re-epithelialisation, collagen maturation, and connective tissue remodelling. Wound healing may be controlled with topical antiseptics, topical antibiotics, herbal remedies, and cellular initiators. In order to effectively eradicate infections and shorten the healing process, contemporary antimicrobial treatments that include antibiotics or antiseptics must be investigated. A variety of delivery systems were described, including innovative delivery systems, hydrogels, microspheres, gold and silver nanoparticles, vesicles, emulsifying systems, nanofibres, artificial dressings, three-dimensional printed skin replacements, dendrimers and carbon nanotubes. It may be inferred that enhanced local delivery methods might be used to provide wound healing agents for faster healing of skin wounds. MDPI 2023-02-13 /pmc/articles/PMC9964694/ /pubmed/36839956 http://dx.doi.org/10.3390/pharmaceutics15020634 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tiwari, Ruchi
Pathak, Kamla
Local Drug Delivery Strategies towards Wound Healing
title Local Drug Delivery Strategies towards Wound Healing
title_full Local Drug Delivery Strategies towards Wound Healing
title_fullStr Local Drug Delivery Strategies towards Wound Healing
title_full_unstemmed Local Drug Delivery Strategies towards Wound Healing
title_short Local Drug Delivery Strategies towards Wound Healing
title_sort local drug delivery strategies towards wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964694/
https://www.ncbi.nlm.nih.gov/pubmed/36839956
http://dx.doi.org/10.3390/pharmaceutics15020634
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