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Challenges in Cerebral Venous Thrombosis Management—Case Reports and Short Literature Review

Cerebral venous thrombosis (CVT) is a rare type of stroke, with a complex clinical presentation that can make it a diagnostic challenge for the swift initiation of anticoagulation. When a hemorrhagic transformation is added, therapeutic management becomes even more complex. We describe a series of f...

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Autores principales: Pleșa, Florentina Cristina, Jijie, Alina, Toma, Gabriela Simona, Ranetti, Aurelian Emilian, Manole, Aida Mihaela, Rotaru, Ruxandra, Caloianu, Ionuț, Anghel, Daniela, Dulămea, Octaviana Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964720/
https://www.ncbi.nlm.nih.gov/pubmed/36836691
http://dx.doi.org/10.3390/life13020334
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author Pleșa, Florentina Cristina
Jijie, Alina
Toma, Gabriela Simona
Ranetti, Aurelian Emilian
Manole, Aida Mihaela
Rotaru, Ruxandra
Caloianu, Ionuț
Anghel, Daniela
Dulămea, Octaviana Adriana
author_facet Pleșa, Florentina Cristina
Jijie, Alina
Toma, Gabriela Simona
Ranetti, Aurelian Emilian
Manole, Aida Mihaela
Rotaru, Ruxandra
Caloianu, Ionuț
Anghel, Daniela
Dulămea, Octaviana Adriana
author_sort Pleșa, Florentina Cristina
collection PubMed
description Cerebral venous thrombosis (CVT) is a rare type of stroke, with a complex clinical presentation that can make it a diagnostic challenge for the swift initiation of anticoagulation. When a hemorrhagic transformation is added, therapeutic management becomes even more complex. We describe a series of four cases, aged between 23 and 37 years old, with cerebral venous thrombosis. They were admitted to our clinic between 2014 and 2022. All cases presented significant challenges in either diagnostic, therapeutic or etiologic evaluation, at different stages of the disease. Late complications such as epilepsy or depression and other behavioral disorders represent long-term sequelae for the patient. Therefore, through its late complications, CVT is not only an acute disease but a chronic disorder with long-term follow-up requirements. The first case of the series is of a postpartum woman with focal neurological deficit caused by CVT with hemorrhagic transformation that presented multiple thrombotic complications and severe depression. The second case is of a man with extensive cerebral thrombosis who developed bilateral papillary edema under therapeutic anticoagulation treatment. The third case is of a woman with bilateral cavernous sinus thrombosis who later developed depressive disorder and focal seizures. The fourth case is of a pregnant woman in the first trimester presenting with a steep decline in consciousness level secondary to deep cerebral vein thrombosis requiring intensive care and subsequently developing a memory disorder. For a long period of time, due to being underdiagnosed, few things were known about CVT. Nowadays, we have all the tools to diagnose, treat, and follow up cases of CVT.
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spelling pubmed-99647202023-02-26 Challenges in Cerebral Venous Thrombosis Management—Case Reports and Short Literature Review Pleșa, Florentina Cristina Jijie, Alina Toma, Gabriela Simona Ranetti, Aurelian Emilian Manole, Aida Mihaela Rotaru, Ruxandra Caloianu, Ionuț Anghel, Daniela Dulămea, Octaviana Adriana Life (Basel) Article Cerebral venous thrombosis (CVT) is a rare type of stroke, with a complex clinical presentation that can make it a diagnostic challenge for the swift initiation of anticoagulation. When a hemorrhagic transformation is added, therapeutic management becomes even more complex. We describe a series of four cases, aged between 23 and 37 years old, with cerebral venous thrombosis. They were admitted to our clinic between 2014 and 2022. All cases presented significant challenges in either diagnostic, therapeutic or etiologic evaluation, at different stages of the disease. Late complications such as epilepsy or depression and other behavioral disorders represent long-term sequelae for the patient. Therefore, through its late complications, CVT is not only an acute disease but a chronic disorder with long-term follow-up requirements. The first case of the series is of a postpartum woman with focal neurological deficit caused by CVT with hemorrhagic transformation that presented multiple thrombotic complications and severe depression. The second case is of a man with extensive cerebral thrombosis who developed bilateral papillary edema under therapeutic anticoagulation treatment. The third case is of a woman with bilateral cavernous sinus thrombosis who later developed depressive disorder and focal seizures. The fourth case is of a pregnant woman in the first trimester presenting with a steep decline in consciousness level secondary to deep cerebral vein thrombosis requiring intensive care and subsequently developing a memory disorder. For a long period of time, due to being underdiagnosed, few things were known about CVT. Nowadays, we have all the tools to diagnose, treat, and follow up cases of CVT. MDPI 2023-01-26 /pmc/articles/PMC9964720/ /pubmed/36836691 http://dx.doi.org/10.3390/life13020334 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pleșa, Florentina Cristina
Jijie, Alina
Toma, Gabriela Simona
Ranetti, Aurelian Emilian
Manole, Aida Mihaela
Rotaru, Ruxandra
Caloianu, Ionuț
Anghel, Daniela
Dulămea, Octaviana Adriana
Challenges in Cerebral Venous Thrombosis Management—Case Reports and Short Literature Review
title Challenges in Cerebral Venous Thrombosis Management—Case Reports and Short Literature Review
title_full Challenges in Cerebral Venous Thrombosis Management—Case Reports and Short Literature Review
title_fullStr Challenges in Cerebral Venous Thrombosis Management—Case Reports and Short Literature Review
title_full_unstemmed Challenges in Cerebral Venous Thrombosis Management—Case Reports and Short Literature Review
title_short Challenges in Cerebral Venous Thrombosis Management—Case Reports and Short Literature Review
title_sort challenges in cerebral venous thrombosis management—case reports and short literature review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964720/
https://www.ncbi.nlm.nih.gov/pubmed/36836691
http://dx.doi.org/10.3390/life13020334
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