Cargando…

HPV16 E6 and E7 Oncoproteins Stimulate the Glutamine Pathway Maintaining Cell Proliferation in a SNAT1-Dependent Fashion

Persistent high-risk human papillomavirus infection is the main risk factor for cervical cancer establishment, where the viral oncogenes E6 and E7 promote a cancerous phenotype. Metabolic reprogramming in cancer involves alterations in glutamine metabolism, also named glutaminolysis, to provide ener...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ortiz-Pedraza, Yunuen, Muñoz-Bello, J. Omar, Ramos-Chávez, Lucio Antonio, Martínez-Ramírez, Imelda, Olmedo-Nieva, Leslie, Manzo-Merino, Joaquín, López-Saavedra, Alejandro, Pérez-de la Cruz, Verónica, Lizano, Marcela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964736/ https://www.ncbi.nlm.nih.gov/pubmed/36851539 http://dx.doi.org/10.3390/v15020324

Ejemplares similares

RIPOR2 Expression Decreased by HPV-16 E6 and E7 Oncoproteins: An Opportunity in the Search for Prognostic Biomarkers in Cervical Cancer
por: Olmedo-Nieva, Leslie, et al.
Publicado: (2022)

HPV-18 E6 Oncoprotein and Its Spliced Isoform E6*I Regulate the Wnt/β-Catenin Cell Signaling Pathway through the TCF-4 Transcriptional Factor
por: Muñoz-Bello, J. Omar, et al.
Publicado: (2018)

Regulation of the Wnt/β-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins
por: Muñoz Bello, Jesus Omar, et al.
Publicado: (2015)

The Human Papillomavirus (HPV) E1 protein regulates the expression of cellular genes involved in immune response
por: Castro-Muñoz, Leonardo Josué, et al.
Publicado: (2019)

Non-Coding RNAs as Key Regulators of Glutaminolysis in Cancer
por: Ortiz-Pedraza, Yunuen, et al.
Publicado: (2020)

The Human Papillomavirus (HPV) E6 Oncoprotein Regulates CD40 Expression via the AT-Hook Transcription Factor AKNA
por: Manzo-Merino, Joaquin, et al.
Publicado: (2018)

Glutamine Uptake via SNAT6 and Caveolin Regulates Glutamine–Glutamate Cycle
por: Gandasi, Nikhil R., et al.
Publicado: (2021)

The Role of E6 Spliced Isoforms (E6*) in Human Papillomavirus-Induced Carcinogenesis
por: Olmedo-Nieva, Leslie, et al.
Publicado: (2018)

Mechanisms of Vasculogenic Mimicry in Ovarian Cancer
por: Ayala-Domínguez, Lízbeth, et al.
Publicado: (2019)

Interaction of the Human Papillomavirus E6 Oncoprotein with Sorting Nexin 27 Modulates Endocytic Cargo Transport Pathways
por: Ganti, Ketaki, et al.
Publicado: (2016)

Role of HPV18 E6 in PKB signal transduction pathways
por: Contreras, Adriana, et al.
Publicado: (2007)

PKC-Mediated Modulation of Astrocyte SNAT3 Glutamine Transporter Function at Synapses in Situ
por: Dong, Wuxing, et al.
Publicado: (2018)

Expression of the HPV18/E6 oncoprotein induces DNA damage
por: Gutierrez, Elva I. Cortes, et al.
Publicado: (2017)

hrHPV E5 oncoprotein: immune evasion and related immunotherapies
por: de Freitas, Antonio Carlos, et al.
Publicado: (2017)

The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis
por: Basukala, Om, et al.
Publicado: (2021)

Transcriptional regulation of E-cadherin and oncoprotein E7 by valproic acid in HPV positive cell lines
por: Faghihloo, Ebrahim, et al.
Publicado: (2016)

Functional Roles of E6 and E7 Oncoproteins in HPV-Induced Malignancies at Diverse Anatomical Sites
por: Tomaić, Vjekoslav
Publicado: (2016)

Inhibition of the glutamine transporter SNAT1 confers neuroprotection in mice by modulating the mTOR-autophagy system
por: Yamada, Daisuke, et al.
Publicado: (2019)

Ubiquitination of the HPV Oncoprotein E6 Is Critical for E6/E6AP-Mediated p53 Degradation
por: Li, Siying, et al.
Publicado: (2019)

HPV18 E1^E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins.
por: Kajitani, Naoko, et al.
Publicado: (2013)

Docosahexaenoic acid induces the degradation of HPV E6/E7 oncoproteins by activating the ubiquitin–proteasome system
por: Jing, K, et al.
Publicado: (2014)

Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins
por: Gutiérrez-Hoya, Adriana, et al.
Publicado: (2020)

The HPV E6 oncoprotein targets histone methyltransferases for modulating specific gene transcription
por: Hsu, C-H, et al.
Publicado: (2012)

An RNA Aptamer Targets the PDZ-Binding Motif of the HPV16 E6 Oncoprotein
por: Belyaeva, Tamara A., et al.
Publicado: (2014)

Intrabodies targeting human papillomavirus 16 E6 and E7 oncoproteins for therapy of established HPV-associated tumors
por: Paolini, Francesca, et al.
Publicado: (2021)

Enzymatic Suppression of the Membrane Conductance Associated with the Glutamine Transporter SNAT3 Expressed in Xenopus Oocytes by Carbonic Anhydrase II
por: Weise, Alexandra, et al.
Publicado: (2007)

NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis
por: Lister, Adam, et al.
Publicado: (2018)

HPV-Induced Oropharyngeal Cancer and the Role of the E7 Oncoprotein Detection via Brush Test
por: Borena, Wegene, et al.
Publicado: (2020)

IRF-1 Inhibits Angiogenic Activity of HPV16 E6 Oncoprotein in Cervical Cancer
por: Rho, Seung Bae, et al.
Publicado: (2020)

Detection of HPV E6 oncoprotein from urine via a novel immunochromatographic assay
por: de Oliveira, Cristina Mendes, et al.
Publicado: (2020)

Molecular Landscape and Computational Screening of the Natural inhibitors against HPV16 E6 Oncoprotein
por: Juneja, Tanzil, et al.
Publicado: (2021)

E6 Oncoproteins from High-Risk Human Papillomavirus Induce Mitochondrial Metabolism in a Head and Neck Squamous Cell Carcinoma Model
por: Cruz-Gregorio, Alfredo, et al.
Publicado: (2019)

HPV E6 and E7 oncoproteins cooperatively alter the expression of Disc Large 1 polarity protein in epithelial cells
por: Dizanzo, María Paula, et al.
Publicado: (2020)

Manipulation of Epithelial Differentiation by HPV Oncoproteins
por: White, Elizabeth A.
Publicado: (2019)

Unique regulation of Na‐glutamine cotransporter SN2/SNAT5 in rabbit intestinal crypt cells during chronic enteritis
por: Singh, Soudamani, et al.
Publicado: (2017)

Elucidating Molecular Interactions of Natural Inhibitors with HPV-16 E6 Oncoprotein through Docking Analysis
por: Kumar, Satish, et al.
Publicado: (2014)

Serum HPV16 E7 Oncoprotein Is a Recurrence Marker of Oropharyngeal Squamous Cell Carcinomas
por: Oton-Gonzalez, Lucia, et al.
Publicado: (2021)

Development and validation of a multiplex immunoassay for the simultaneous quantification of type-specific IgG antibodies to E6/E7 oncoproteins of HPV16 and HPV18
por: Layman, Hans, et al.
Publicado: (2020)

Involvement of aryl hydrocarbon receptor signaling in the development of small cell lung cancer induced by HPV E6/E7 oncoproteins
por: Buonomo, Tonia, et al.
Publicado: (2011)

Increased expression of glutamine transporter SNAT2/SLC38A2 promotes glutamine dependence and oxidative stress resistance, and is associated with worse prognosis in triple-negative breast cancer
por: Morotti, Matteo, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fm5bevla9dg7d119n9dj9n9eq1