Mechanism of Action and Structure–Activity Relationships of Tetracyclic Small Molecules Acting as Universal Positive Allosteric Modulators of the Cholecystokinin Receptor

As part of an ongoing effort to develop a drug targeting the type 1 cholecystokinin receptor (CCK1R) to help prevent and/or treat obesity, we recently performed a high throughput screening effort of small molecules seeking candidates that enhanced the action of the natural agonist, CCK, thus acting...

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Detalles Bibliográficos
Autores principales: Dengler, Daniela G., Harikumar, Kaleeckal G., Yen, Alice, Sergienko, Eduard A., Miller, Laurence J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964746/
https://www.ncbi.nlm.nih.gov/pubmed/36837653
http://dx.doi.org/10.3390/membranes13020150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964746/
https://www.ncbi.nlm.nih.gov/pubmed/36837653
http://dx.doi.org/10.3390/membranes13020150

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