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Deciphering Differential Behavior of Immune Responses as the Foundation for Precision Dosing in Allergen Immunotherapy

Like in many fields of medicine, the concept of precision dosing has re-emerged in routine practice in allergology. Only one retrospective study on French physicians’ practice has addressed this topic so far and generated preliminary data supporting dose adaptation, mainly based on experience, patie...

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Autores principales: Magnan, Antoine, Nicolas, Jean-François, Caimmi, Davide, Vocanson, Marc, Haddad, Thierry, Colas, Luc, Scurati, Silvia, Mascarell, Laurent, Shamji, Mohamed H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964800/
https://www.ncbi.nlm.nih.gov/pubmed/36836557
http://dx.doi.org/10.3390/jpm13020324
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author Magnan, Antoine
Nicolas, Jean-François
Caimmi, Davide
Vocanson, Marc
Haddad, Thierry
Colas, Luc
Scurati, Silvia
Mascarell, Laurent
Shamji, Mohamed H.
author_facet Magnan, Antoine
Nicolas, Jean-François
Caimmi, Davide
Vocanson, Marc
Haddad, Thierry
Colas, Luc
Scurati, Silvia
Mascarell, Laurent
Shamji, Mohamed H.
author_sort Magnan, Antoine
collection PubMed
description Like in many fields of medicine, the concept of precision dosing has re-emerged in routine practice in allergology. Only one retrospective study on French physicians’ practice has addressed this topic so far and generated preliminary data supporting dose adaptation, mainly based on experience, patient profile understanding and response to treatment. Both intrinsic and extrinsic factors shape the individual immune system response to allergen immunotherapy (AIT). Herein, we focus on key immune cells (i.e., dendritic cells, innate lymphoid cells, B and T cells, basophils and mast cells) involved in allergic disease and its resolution to further understand the effect of AIT on the phenotype, frequency or polarization of these cells. We strive to discriminate differences in immune responses between responders and non-responders to AIT, and discuss the eligibility of a non/low-responder subset for dose adaptation. A differential behavior in immune cells is clearly observed in responders, highlighting the importance of conducting clinical trials with large cohorts of well-characterized subjects to decipher the immune mechanism of AIT. We conclude that there is a need for designing new clinical and mechanistic studies to support the scientific rationale of dose adaptation in the interest of patients who do not properly respond to AIT.
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spelling pubmed-99648002023-02-26 Deciphering Differential Behavior of Immune Responses as the Foundation for Precision Dosing in Allergen Immunotherapy Magnan, Antoine Nicolas, Jean-François Caimmi, Davide Vocanson, Marc Haddad, Thierry Colas, Luc Scurati, Silvia Mascarell, Laurent Shamji, Mohamed H. J Pers Med Review Like in many fields of medicine, the concept of precision dosing has re-emerged in routine practice in allergology. Only one retrospective study on French physicians’ practice has addressed this topic so far and generated preliminary data supporting dose adaptation, mainly based on experience, patient profile understanding and response to treatment. Both intrinsic and extrinsic factors shape the individual immune system response to allergen immunotherapy (AIT). Herein, we focus on key immune cells (i.e., dendritic cells, innate lymphoid cells, B and T cells, basophils and mast cells) involved in allergic disease and its resolution to further understand the effect of AIT on the phenotype, frequency or polarization of these cells. We strive to discriminate differences in immune responses between responders and non-responders to AIT, and discuss the eligibility of a non/low-responder subset for dose adaptation. A differential behavior in immune cells is clearly observed in responders, highlighting the importance of conducting clinical trials with large cohorts of well-characterized subjects to decipher the immune mechanism of AIT. We conclude that there is a need for designing new clinical and mechanistic studies to support the scientific rationale of dose adaptation in the interest of patients who do not properly respond to AIT. MDPI 2023-02-13 /pmc/articles/PMC9964800/ /pubmed/36836557 http://dx.doi.org/10.3390/jpm13020324 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Magnan, Antoine
Nicolas, Jean-François
Caimmi, Davide
Vocanson, Marc
Haddad, Thierry
Colas, Luc
Scurati, Silvia
Mascarell, Laurent
Shamji, Mohamed H.
Deciphering Differential Behavior of Immune Responses as the Foundation for Precision Dosing in Allergen Immunotherapy
title Deciphering Differential Behavior of Immune Responses as the Foundation for Precision Dosing in Allergen Immunotherapy
title_full Deciphering Differential Behavior of Immune Responses as the Foundation for Precision Dosing in Allergen Immunotherapy
title_fullStr Deciphering Differential Behavior of Immune Responses as the Foundation for Precision Dosing in Allergen Immunotherapy
title_full_unstemmed Deciphering Differential Behavior of Immune Responses as the Foundation for Precision Dosing in Allergen Immunotherapy
title_short Deciphering Differential Behavior of Immune Responses as the Foundation for Precision Dosing in Allergen Immunotherapy
title_sort deciphering differential behavior of immune responses as the foundation for precision dosing in allergen immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964800/
https://www.ncbi.nlm.nih.gov/pubmed/36836557
http://dx.doi.org/10.3390/jpm13020324
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