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The Strategies of Development of New Non-Toxic Inhibitors of Amyloid Formation
In recent years, due to the aging of the population and the development of diagnostic medicine, the number of identified diseases associated with the accumulation of amyloid proteins has increased. Some of these proteins are known to cause a number of degenerative diseases in humans, such as amyloid...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964835/ https://www.ncbi.nlm.nih.gov/pubmed/36835194 http://dx.doi.org/10.3390/ijms24043781 |
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author | Galzitskaya, Oxana V. Grishin, Sergei Y. Glyakina, Anna V. Dovidchenko, Nikita V. Konstantinova, Anastasiia V. Kravchenko, Sergey V. Surin, Alexey K. |
author_facet | Galzitskaya, Oxana V. Grishin, Sergei Y. Glyakina, Anna V. Dovidchenko, Nikita V. Konstantinova, Anastasiia V. Kravchenko, Sergey V. Surin, Alexey K. |
author_sort | Galzitskaya, Oxana V. |
collection | PubMed |
description | In recent years, due to the aging of the population and the development of diagnostic medicine, the number of identified diseases associated with the accumulation of amyloid proteins has increased. Some of these proteins are known to cause a number of degenerative diseases in humans, such as amyloid-beta (Aβ) in Alzheimer’s disease (AD), α-synuclein in Parkinson’s disease (PD), and insulin and its analogues in insulin-derived amyloidosis. In this regard, it is important to develop strategies for the search and development of effective inhibitors of amyloid formation. Many studies have been carried out aimed at elucidating the mechanisms of amyloid aggregation of proteins and peptides. This review focuses on three amyloidogenic peptides and proteins—Aβ, α-synuclein, and insulin—for which we will consider amyloid fibril formation mechanisms and analyze existing and prospective strategies for the development of effective and non-toxic inhibitors of amyloid formation. The development of non-toxic inhibitors of amyloid will allow them to be used more effectively for the treatment of diseases associated with amyloid. |
format | Online Article Text |
id | pubmed-9964835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99648352023-02-26 The Strategies of Development of New Non-Toxic Inhibitors of Amyloid Formation Galzitskaya, Oxana V. Grishin, Sergei Y. Glyakina, Anna V. Dovidchenko, Nikita V. Konstantinova, Anastasiia V. Kravchenko, Sergey V. Surin, Alexey K. Int J Mol Sci Review In recent years, due to the aging of the population and the development of diagnostic medicine, the number of identified diseases associated with the accumulation of amyloid proteins has increased. Some of these proteins are known to cause a number of degenerative diseases in humans, such as amyloid-beta (Aβ) in Alzheimer’s disease (AD), α-synuclein in Parkinson’s disease (PD), and insulin and its analogues in insulin-derived amyloidosis. In this regard, it is important to develop strategies for the search and development of effective inhibitors of amyloid formation. Many studies have been carried out aimed at elucidating the mechanisms of amyloid aggregation of proteins and peptides. This review focuses on three amyloidogenic peptides and proteins—Aβ, α-synuclein, and insulin—for which we will consider amyloid fibril formation mechanisms and analyze existing and prospective strategies for the development of effective and non-toxic inhibitors of amyloid formation. The development of non-toxic inhibitors of amyloid will allow them to be used more effectively for the treatment of diseases associated with amyloid. MDPI 2023-02-14 /pmc/articles/PMC9964835/ /pubmed/36835194 http://dx.doi.org/10.3390/ijms24043781 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Galzitskaya, Oxana V. Grishin, Sergei Y. Glyakina, Anna V. Dovidchenko, Nikita V. Konstantinova, Anastasiia V. Kravchenko, Sergey V. Surin, Alexey K. The Strategies of Development of New Non-Toxic Inhibitors of Amyloid Formation |
title | The Strategies of Development of New Non-Toxic Inhibitors of Amyloid Formation |
title_full | The Strategies of Development of New Non-Toxic Inhibitors of Amyloid Formation |
title_fullStr | The Strategies of Development of New Non-Toxic Inhibitors of Amyloid Formation |
title_full_unstemmed | The Strategies of Development of New Non-Toxic Inhibitors of Amyloid Formation |
title_short | The Strategies of Development of New Non-Toxic Inhibitors of Amyloid Formation |
title_sort | strategies of development of new non-toxic inhibitors of amyloid formation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964835/ https://www.ncbi.nlm.nih.gov/pubmed/36835194 http://dx.doi.org/10.3390/ijms24043781 |
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