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Comparison of Retinal Structural and Neurovascular Changes between Patients with and without Amyloid Pathology

To evaluate whether an impaired anterior visual pathway (retinal structures with microvasculature) is associated with underlying beta-amyloid (Aβ) pathologies in patients with Alzheimer’s disease dementia (ADD) and mild cognitive impairment (MCI), we compared retinal structural and vascular factors...

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Autores principales: Moon, Sangwoo, Jeon, Sumin, Seo, Sook Kyeong, Kim, Da Eun, Jung, Na-Yeon, Kim, Seung Joo, Lee, Myung Jun, Lee, Jiwoong, Kim, Eun-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964845/
https://www.ncbi.nlm.nih.gov/pubmed/36835845
http://dx.doi.org/10.3390/jcm12041310
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author Moon, Sangwoo
Jeon, Sumin
Seo, Sook Kyeong
Kim, Da Eun
Jung, Na-Yeon
Kim, Seung Joo
Lee, Myung Jun
Lee, Jiwoong
Kim, Eun-Joo
author_facet Moon, Sangwoo
Jeon, Sumin
Seo, Sook Kyeong
Kim, Da Eun
Jung, Na-Yeon
Kim, Seung Joo
Lee, Myung Jun
Lee, Jiwoong
Kim, Eun-Joo
author_sort Moon, Sangwoo
collection PubMed
description To evaluate whether an impaired anterior visual pathway (retinal structures with microvasculature) is associated with underlying beta-amyloid (Aβ) pathologies in patients with Alzheimer’s disease dementia (ADD) and mild cognitive impairment (MCI), we compared retinal structural and vascular factors in each subgroup with positive or negative amyloid biomarkers. Twenty-seven patients with dementia, thirty-five with MCI, and nine with cognitively unimpaired (CU) controls were consecutively recruited. All participants were divided into positive Aβ (A+) or negative Aβ (A−) pathology based on amyloid positron emission tomography or cerebrospinal fluid Aβ. The retinal circumpapillary retinal nerve fiber layer thickness (cpRNFLT), macular ganglion cell/inner plexiform layer thickness (mGC/IPLT), and microcirculation of the macular superficial capillary plexus were measured using optical coherence tomography (OCT) and OCT angiography. One eye of each participant was included in the analysis. Retinal structural and vascular factors significantly decreased in the following order: dementia < MCI < CU controls. The A+ group had significantly lower microcirculation in the para- and peri-foveal temporal regions than did the A−. However, the structural and vascular parameters did not differ between the A+ and A− with dementia. The cpRNFLT was unexpectedly greater in the A+ than in the A− with MCI. mGC/IPLT was lower in the A+ CU than in the A− CU. Our findings suggest that retinal structural changes may occur in the preclinical and early stages of dementia but are not highly specific to AD pathophysiology. In contrast, decreased temporal macula microcirculation may be used as a biomarker for the underlying Aβ pathology.
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spelling pubmed-99648452023-02-26 Comparison of Retinal Structural and Neurovascular Changes between Patients with and without Amyloid Pathology Moon, Sangwoo Jeon, Sumin Seo, Sook Kyeong Kim, Da Eun Jung, Na-Yeon Kim, Seung Joo Lee, Myung Jun Lee, Jiwoong Kim, Eun-Joo J Clin Med Article To evaluate whether an impaired anterior visual pathway (retinal structures with microvasculature) is associated with underlying beta-amyloid (Aβ) pathologies in patients with Alzheimer’s disease dementia (ADD) and mild cognitive impairment (MCI), we compared retinal structural and vascular factors in each subgroup with positive or negative amyloid biomarkers. Twenty-seven patients with dementia, thirty-five with MCI, and nine with cognitively unimpaired (CU) controls were consecutively recruited. All participants were divided into positive Aβ (A+) or negative Aβ (A−) pathology based on amyloid positron emission tomography or cerebrospinal fluid Aβ. The retinal circumpapillary retinal nerve fiber layer thickness (cpRNFLT), macular ganglion cell/inner plexiform layer thickness (mGC/IPLT), and microcirculation of the macular superficial capillary plexus were measured using optical coherence tomography (OCT) and OCT angiography. One eye of each participant was included in the analysis. Retinal structural and vascular factors significantly decreased in the following order: dementia < MCI < CU controls. The A+ group had significantly lower microcirculation in the para- and peri-foveal temporal regions than did the A−. However, the structural and vascular parameters did not differ between the A+ and A− with dementia. The cpRNFLT was unexpectedly greater in the A+ than in the A− with MCI. mGC/IPLT was lower in the A+ CU than in the A− CU. Our findings suggest that retinal structural changes may occur in the preclinical and early stages of dementia but are not highly specific to AD pathophysiology. In contrast, decreased temporal macula microcirculation may be used as a biomarker for the underlying Aβ pathology. MDPI 2023-02-07 /pmc/articles/PMC9964845/ /pubmed/36835845 http://dx.doi.org/10.3390/jcm12041310 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moon, Sangwoo
Jeon, Sumin
Seo, Sook Kyeong
Kim, Da Eun
Jung, Na-Yeon
Kim, Seung Joo
Lee, Myung Jun
Lee, Jiwoong
Kim, Eun-Joo
Comparison of Retinal Structural and Neurovascular Changes between Patients with and without Amyloid Pathology
title Comparison of Retinal Structural and Neurovascular Changes between Patients with and without Amyloid Pathology
title_full Comparison of Retinal Structural and Neurovascular Changes between Patients with and without Amyloid Pathology
title_fullStr Comparison of Retinal Structural and Neurovascular Changes between Patients with and without Amyloid Pathology
title_full_unstemmed Comparison of Retinal Structural and Neurovascular Changes between Patients with and without Amyloid Pathology
title_short Comparison of Retinal Structural and Neurovascular Changes between Patients with and without Amyloid Pathology
title_sort comparison of retinal structural and neurovascular changes between patients with and without amyloid pathology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964845/
https://www.ncbi.nlm.nih.gov/pubmed/36835845
http://dx.doi.org/10.3390/jcm12041310
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