Cargando…

Could Mid- to Late-Onset Glaucoma Be Associated with an Increased Risk of Incident Dementia? A Nationwide Retrospective Cohort Study

This study aimed to investigate the possible link between glaucoma and dementia using a nationwide cohort sample of data. The glaucoma group (n = 875) included patients diagnosed between 2003 and 2005, aged over 55 years; the comparison group was selected using propensity score matching (n = 3500)....

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Dong-Kyu, Lee, So Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964967/
https://www.ncbi.nlm.nih.gov/pubmed/36836447
http://dx.doi.org/10.3390/jpm13020214
_version_ 1784896640169017344
author Kim, Dong-Kyu
Lee, So Yeon
author_facet Kim, Dong-Kyu
Lee, So Yeon
author_sort Kim, Dong-Kyu
collection PubMed
description This study aimed to investigate the possible link between glaucoma and dementia using a nationwide cohort sample of data. The glaucoma group (n = 875) included patients diagnosed between 2003 and 2005, aged over 55 years; the comparison group was selected using propensity score matching (n = 3500). The incidence of all-cause dementia was 18.67 (7014.7 person-years) among those with glaucoma aged over 55 years. The glaucoma group developed all-cause dementia more frequently than those in the comparison group (adjusted hazard ratio (HR) = 1.43, 95% confidence interval (CI), 1.17–1.74). In a subgroup analysis, primary open-angle glaucoma (POAG) showed a significantly increased adjusted HR for all-cause dementia events (1.52, 95% CI: 1.23–1.89), whereas we could not find any significant association in patients with primary angle-closure glaucoma (PACG). Additionally, POAG patients showed an increased risk of the development of Alzheimer’s disease (adjusted HR = 1.57, 95% CI, 1.21–2.04) and Parkinson’s disease (adjusted HR = 2.29, 95% CI, 1.46–3.61), but there was no significant difference in PACG patients. Moreover, the risk of Alzheimer’s disease and Parkinson’s disease was higher within 2 years of POAG diagnosis. Although our findings have some limitations, such as confounding factor bias, we suggest that clinicians should pay attention to the early detection of dementia in patients with POAG.
format Online
Article
Text
id pubmed-9964967
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99649672023-02-26 Could Mid- to Late-Onset Glaucoma Be Associated with an Increased Risk of Incident Dementia? A Nationwide Retrospective Cohort Study Kim, Dong-Kyu Lee, So Yeon J Pers Med Article This study aimed to investigate the possible link between glaucoma and dementia using a nationwide cohort sample of data. The glaucoma group (n = 875) included patients diagnosed between 2003 and 2005, aged over 55 years; the comparison group was selected using propensity score matching (n = 3500). The incidence of all-cause dementia was 18.67 (7014.7 person-years) among those with glaucoma aged over 55 years. The glaucoma group developed all-cause dementia more frequently than those in the comparison group (adjusted hazard ratio (HR) = 1.43, 95% confidence interval (CI), 1.17–1.74). In a subgroup analysis, primary open-angle glaucoma (POAG) showed a significantly increased adjusted HR for all-cause dementia events (1.52, 95% CI: 1.23–1.89), whereas we could not find any significant association in patients with primary angle-closure glaucoma (PACG). Additionally, POAG patients showed an increased risk of the development of Alzheimer’s disease (adjusted HR = 1.57, 95% CI, 1.21–2.04) and Parkinson’s disease (adjusted HR = 2.29, 95% CI, 1.46–3.61), but there was no significant difference in PACG patients. Moreover, the risk of Alzheimer’s disease and Parkinson’s disease was higher within 2 years of POAG diagnosis. Although our findings have some limitations, such as confounding factor bias, we suggest that clinicians should pay attention to the early detection of dementia in patients with POAG. MDPI 2023-01-26 /pmc/articles/PMC9964967/ /pubmed/36836447 http://dx.doi.org/10.3390/jpm13020214 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Dong-Kyu
Lee, So Yeon
Could Mid- to Late-Onset Glaucoma Be Associated with an Increased Risk of Incident Dementia? A Nationwide Retrospective Cohort Study
title Could Mid- to Late-Onset Glaucoma Be Associated with an Increased Risk of Incident Dementia? A Nationwide Retrospective Cohort Study
title_full Could Mid- to Late-Onset Glaucoma Be Associated with an Increased Risk of Incident Dementia? A Nationwide Retrospective Cohort Study
title_fullStr Could Mid- to Late-Onset Glaucoma Be Associated with an Increased Risk of Incident Dementia? A Nationwide Retrospective Cohort Study
title_full_unstemmed Could Mid- to Late-Onset Glaucoma Be Associated with an Increased Risk of Incident Dementia? A Nationwide Retrospective Cohort Study
title_short Could Mid- to Late-Onset Glaucoma Be Associated with an Increased Risk of Incident Dementia? A Nationwide Retrospective Cohort Study
title_sort could mid- to late-onset glaucoma be associated with an increased risk of incident dementia? a nationwide retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964967/
https://www.ncbi.nlm.nih.gov/pubmed/36836447
http://dx.doi.org/10.3390/jpm13020214
work_keys_str_mv AT kimdongkyu couldmidtolateonsetglaucomabeassociatedwithanincreasedriskofincidentdementiaanationwideretrospectivecohortstudy
AT leesoyeon couldmidtolateonsetglaucomabeassociatedwithanincreasedriskofincidentdementiaanationwideretrospectivecohortstudy