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Mesoporous Bioactive Nanoparticles for Bone Tissue Applications

Research in nanomaterials with applications in bone regeneration therapies has experienced a very significant advance with the development of bioactive mesoporous nanoparticles (MBNPs). These nanomaterials consist of small spherical particles that exhibit chemical properties and porous structures th...

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Detalles Bibliográficos
Autores principales: Arcos, Daniel, Portolés, María Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964985/
https://www.ncbi.nlm.nih.gov/pubmed/36834659
http://dx.doi.org/10.3390/ijms24043249
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author Arcos, Daniel
Portolés, María Teresa
author_facet Arcos, Daniel
Portolés, María Teresa
author_sort Arcos, Daniel
collection PubMed
description Research in nanomaterials with applications in bone regeneration therapies has experienced a very significant advance with the development of bioactive mesoporous nanoparticles (MBNPs). These nanomaterials consist of small spherical particles that exhibit chemical properties and porous structures that stimulate bone tissue regeneration, since they have a composition similar to that of conventional sol–gel bioactive glasses and high specific surface area and porosity values. The rational design of mesoporosity and their ability to incorporate drugs make MBNPs an excellent tool for the treatment of bone defects, as well as the pathologies that cause them, such as osteoporosis, bone cancer, and infection, among others. Moreover, the small size of MBNPs allows them to penetrate inside the cells, provoking specific cellular responses that conventional bone grafts cannot perform. In this review, different aspects of MBNPs are comprehensively collected and discussed, including synthesis strategies, behavior as drug delivery systems, incorporation of therapeutic ions, formation of composites, specific cellular response and, finally, in vivo studies that have been performed to date.
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spelling pubmed-99649852023-02-26 Mesoporous Bioactive Nanoparticles for Bone Tissue Applications Arcos, Daniel Portolés, María Teresa Int J Mol Sci Review Research in nanomaterials with applications in bone regeneration therapies has experienced a very significant advance with the development of bioactive mesoporous nanoparticles (MBNPs). These nanomaterials consist of small spherical particles that exhibit chemical properties and porous structures that stimulate bone tissue regeneration, since they have a composition similar to that of conventional sol–gel bioactive glasses and high specific surface area and porosity values. The rational design of mesoporosity and their ability to incorporate drugs make MBNPs an excellent tool for the treatment of bone defects, as well as the pathologies that cause them, such as osteoporosis, bone cancer, and infection, among others. Moreover, the small size of MBNPs allows them to penetrate inside the cells, provoking specific cellular responses that conventional bone grafts cannot perform. In this review, different aspects of MBNPs are comprehensively collected and discussed, including synthesis strategies, behavior as drug delivery systems, incorporation of therapeutic ions, formation of composites, specific cellular response and, finally, in vivo studies that have been performed to date. MDPI 2023-02-07 /pmc/articles/PMC9964985/ /pubmed/36834659 http://dx.doi.org/10.3390/ijms24043249 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Arcos, Daniel
Portolés, María Teresa
Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
title Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
title_full Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
title_fullStr Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
title_full_unstemmed Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
title_short Mesoporous Bioactive Nanoparticles for Bone Tissue Applications
title_sort mesoporous bioactive nanoparticles for bone tissue applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964985/
https://www.ncbi.nlm.nih.gov/pubmed/36834659
http://dx.doi.org/10.3390/ijms24043249
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