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Utility of Opportunistic Infections, Joints’ Involvement and Accuracy of Various Screening Tests to Diagnose Rheumatoid Arthritis Patients

Background and Objectives: Rheumatoid Arthritis (RA) is an auto-immune disease in which the body mistakenly considers some parts of its own system as pathogens and attacks them. Prevalence is approximately 0.75% in India. About 40% of the diseased become work disabled within 5 years from the onset o...

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Autores principales: Ahmad, Ausaf, Khan, Ashfaque, Khan, Abdur Raheem, Ahmed, Hashim, Alajam, Ramzi Abdu, Alshehri, Mohammed M., Ganesan, Bhuvanesh Babu Mondey, Dayah, Salma Jabril Abu, Shaphe, Mohammad Abu, Alameer, Abdulaziz H., Esht, Vandana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964989/
https://www.ncbi.nlm.nih.gov/pubmed/36837567
http://dx.doi.org/10.3390/medicina59020367
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author Ahmad, Ausaf
Khan, Ashfaque
Khan, Abdur Raheem
Ahmed, Hashim
Alajam, Ramzi Abdu
Alshehri, Mohammed M.
Ganesan, Bhuvanesh Babu Mondey
Dayah, Salma Jabril Abu
Shaphe, Mohammad Abu
Alameer, Abdulaziz H.
Esht, Vandana
author_facet Ahmad, Ausaf
Khan, Ashfaque
Khan, Abdur Raheem
Ahmed, Hashim
Alajam, Ramzi Abdu
Alshehri, Mohammed M.
Ganesan, Bhuvanesh Babu Mondey
Dayah, Salma Jabril Abu
Shaphe, Mohammad Abu
Alameer, Abdulaziz H.
Esht, Vandana
author_sort Ahmad, Ausaf
collection PubMed
description Background and Objectives: Rheumatoid Arthritis (RA) is an auto-immune disease in which the body mistakenly considers some parts of its own system as pathogens and attacks them. Prevalence is approximately 0.75% in India. About 40% of the diseased become work disabled within 5 years from the onset of symptoms. The objective of this paper is to assess the sign/symptoms, joints’ involvement, difficulties in daily activities and screening accuracy of serology tests of clinically suspected RA patients. Material and Methods: A cross-sectional cohort study design was conducted on two hundred ninety clinically suspected subjects who were referred by different OPDs of hospitals for screening. The profiles of study subjects were carried through a semi-structured, pre-tested schedule method. About 2 mL of blood samples were collected in a plain vial from each patient and tested for diagnostic tests RF, CRP and AntiCCP by using RF-Latex, CRP Latex and ELISA method, respectively, by the laboratory persons. Results: Joint pain shows to be a leading problem in RA as compared to other signs and symptoms. The majority of the study subjects suffer from knee problems (62%). Approximately equal numbers of RA-positive cases were screened by RF and AntiCCP tests. The CRP test screened about one-third of cases. CRP+ AntiCCP, RF+ AntiCCP and RF + CRP all have good sensitivity, and RF+ AntiCCP + CRP has a very high sensitivity for diagnosing RA. Conclusions: This study found that a substantiation of a major proportion of clinically suspected RA patients were suffering from knee pain. Predication of AntiCCP increased the possibility for the diagnosis of RA. However, RF was also moderately related to the diagnosis of RA, and the combination of both tests was more valuable.
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spelling pubmed-99649892023-02-26 Utility of Opportunistic Infections, Joints’ Involvement and Accuracy of Various Screening Tests to Diagnose Rheumatoid Arthritis Patients Ahmad, Ausaf Khan, Ashfaque Khan, Abdur Raheem Ahmed, Hashim Alajam, Ramzi Abdu Alshehri, Mohammed M. Ganesan, Bhuvanesh Babu Mondey Dayah, Salma Jabril Abu Shaphe, Mohammad Abu Alameer, Abdulaziz H. Esht, Vandana Medicina (Kaunas) Article Background and Objectives: Rheumatoid Arthritis (RA) is an auto-immune disease in which the body mistakenly considers some parts of its own system as pathogens and attacks them. Prevalence is approximately 0.75% in India. About 40% of the diseased become work disabled within 5 years from the onset of symptoms. The objective of this paper is to assess the sign/symptoms, joints’ involvement, difficulties in daily activities and screening accuracy of serology tests of clinically suspected RA patients. Material and Methods: A cross-sectional cohort study design was conducted on two hundred ninety clinically suspected subjects who were referred by different OPDs of hospitals for screening. The profiles of study subjects were carried through a semi-structured, pre-tested schedule method. About 2 mL of blood samples were collected in a plain vial from each patient and tested for diagnostic tests RF, CRP and AntiCCP by using RF-Latex, CRP Latex and ELISA method, respectively, by the laboratory persons. Results: Joint pain shows to be a leading problem in RA as compared to other signs and symptoms. The majority of the study subjects suffer from knee problems (62%). Approximately equal numbers of RA-positive cases were screened by RF and AntiCCP tests. The CRP test screened about one-third of cases. CRP+ AntiCCP, RF+ AntiCCP and RF + CRP all have good sensitivity, and RF+ AntiCCP + CRP has a very high sensitivity for diagnosing RA. Conclusions: This study found that a substantiation of a major proportion of clinically suspected RA patients were suffering from knee pain. Predication of AntiCCP increased the possibility for the diagnosis of RA. However, RF was also moderately related to the diagnosis of RA, and the combination of both tests was more valuable. MDPI 2023-02-14 /pmc/articles/PMC9964989/ /pubmed/36837567 http://dx.doi.org/10.3390/medicina59020367 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ahmad, Ausaf
Khan, Ashfaque
Khan, Abdur Raheem
Ahmed, Hashim
Alajam, Ramzi Abdu
Alshehri, Mohammed M.
Ganesan, Bhuvanesh Babu Mondey
Dayah, Salma Jabril Abu
Shaphe, Mohammad Abu
Alameer, Abdulaziz H.
Esht, Vandana
Utility of Opportunistic Infections, Joints’ Involvement and Accuracy of Various Screening Tests to Diagnose Rheumatoid Arthritis Patients
title Utility of Opportunistic Infections, Joints’ Involvement and Accuracy of Various Screening Tests to Diagnose Rheumatoid Arthritis Patients
title_full Utility of Opportunistic Infections, Joints’ Involvement and Accuracy of Various Screening Tests to Diagnose Rheumatoid Arthritis Patients
title_fullStr Utility of Opportunistic Infections, Joints’ Involvement and Accuracy of Various Screening Tests to Diagnose Rheumatoid Arthritis Patients
title_full_unstemmed Utility of Opportunistic Infections, Joints’ Involvement and Accuracy of Various Screening Tests to Diagnose Rheumatoid Arthritis Patients
title_short Utility of Opportunistic Infections, Joints’ Involvement and Accuracy of Various Screening Tests to Diagnose Rheumatoid Arthritis Patients
title_sort utility of opportunistic infections, joints’ involvement and accuracy of various screening tests to diagnose rheumatoid arthritis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964989/
https://www.ncbi.nlm.nih.gov/pubmed/36837567
http://dx.doi.org/10.3390/medicina59020367
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