Cargando…
Chitotriosidase and Neopterin as Potential Biomarkers for the Evaluation of Complicated Cholecystitis—A Pilot Study
Gallstones are a common surgical pathology. Laparoscopic cholecystectomy represents the elective treatment. Complicated cases can increase the rate of conversion, the duration, and the difficulty of the intervention, along with the hospitalization period. A prospective cohort study was conducted on...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964990/ https://www.ncbi.nlm.nih.gov/pubmed/36836175 http://dx.doi.org/10.3390/jcm12041641 |
_version_ | 1784896645865930752 |
---|---|
author | Nechita, Vlad-Ionuţ Hajjar, Nadim Al Drugan, Cristina Cătană, Cristina-Sorina Moiş, Emil Nechita, Mihaela-Ancuţa Graur, Florin |
author_facet | Nechita, Vlad-Ionuţ Hajjar, Nadim Al Drugan, Cristina Cătană, Cristina-Sorina Moiş, Emil Nechita, Mihaela-Ancuţa Graur, Florin |
author_sort | Nechita, Vlad-Ionuţ |
collection | PubMed |
description | Gallstones are a common surgical pathology. Laparoscopic cholecystectomy represents the elective treatment. Complicated cases can increase the rate of conversion, the duration, and the difficulty of the intervention, along with the hospitalization period. A prospective cohort study was conducted on 51 patients with gallstones. Only subjects with normal renal, pancreatic, and hepatic functions were included. The severity of cholecystitis was evaluated by considering the ultrasound examination, intraoperative findings, and pathology report. We evaluated two potential biomarkers, namely neopterin and chitotriosidase, by comparing their levels before and after the intervention for chronic (n = 36) and complicated (n = 15) cases, as well as their eventual association with the hospitalization period. Subjects with complicated cholecystitis had significantly higher (p = 0.01) neopterin levels at presentation (16.82 nmol/L vs. 11.92 nmol/L, median values), but the differences in chitotriosidase activity between complicated (170.00 nmol/mL/h) and chronic (160.00 nmol/mL/h) cases were not significant (p = 0.66). Patients with neopterin levels above the cut-off value 14.69 nmol/L had a 3.34 times higher risk of complicated cholecystitis. Twenty-four hours after the laparoscopic cholecystectomy, the differences in neopterin level and chitotriosidase activity between chronic and complicated cases were not significant. A significant decrease in chitotriosidase activity was observed after the intervention, only for complicated cases (190 nmol/mL/h vs. 145 nmol/mL/h, p = 0.007); for neopterin, the postoperative decrease was not statistically significant (19.42 nmol/L vs. 10.92 nmol/L, p = 0.06). No significant association with the hospitalization period was observed. Neopterin may be a useful biomarker for complicated cholecystitis, and chitotriosidase may have prognostic utility in early patient follow-up. |
format | Online Article Text |
id | pubmed-9964990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99649902023-02-26 Chitotriosidase and Neopterin as Potential Biomarkers for the Evaluation of Complicated Cholecystitis—A Pilot Study Nechita, Vlad-Ionuţ Hajjar, Nadim Al Drugan, Cristina Cătană, Cristina-Sorina Moiş, Emil Nechita, Mihaela-Ancuţa Graur, Florin J Clin Med Article Gallstones are a common surgical pathology. Laparoscopic cholecystectomy represents the elective treatment. Complicated cases can increase the rate of conversion, the duration, and the difficulty of the intervention, along with the hospitalization period. A prospective cohort study was conducted on 51 patients with gallstones. Only subjects with normal renal, pancreatic, and hepatic functions were included. The severity of cholecystitis was evaluated by considering the ultrasound examination, intraoperative findings, and pathology report. We evaluated two potential biomarkers, namely neopterin and chitotriosidase, by comparing their levels before and after the intervention for chronic (n = 36) and complicated (n = 15) cases, as well as their eventual association with the hospitalization period. Subjects with complicated cholecystitis had significantly higher (p = 0.01) neopterin levels at presentation (16.82 nmol/L vs. 11.92 nmol/L, median values), but the differences in chitotriosidase activity between complicated (170.00 nmol/mL/h) and chronic (160.00 nmol/mL/h) cases were not significant (p = 0.66). Patients with neopterin levels above the cut-off value 14.69 nmol/L had a 3.34 times higher risk of complicated cholecystitis. Twenty-four hours after the laparoscopic cholecystectomy, the differences in neopterin level and chitotriosidase activity between chronic and complicated cases were not significant. A significant decrease in chitotriosidase activity was observed after the intervention, only for complicated cases (190 nmol/mL/h vs. 145 nmol/mL/h, p = 0.007); for neopterin, the postoperative decrease was not statistically significant (19.42 nmol/L vs. 10.92 nmol/L, p = 0.06). No significant association with the hospitalization period was observed. Neopterin may be a useful biomarker for complicated cholecystitis, and chitotriosidase may have prognostic utility in early patient follow-up. MDPI 2023-02-18 /pmc/articles/PMC9964990/ /pubmed/36836175 http://dx.doi.org/10.3390/jcm12041641 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Nechita, Vlad-Ionuţ Hajjar, Nadim Al Drugan, Cristina Cătană, Cristina-Sorina Moiş, Emil Nechita, Mihaela-Ancuţa Graur, Florin Chitotriosidase and Neopterin as Potential Biomarkers for the Evaluation of Complicated Cholecystitis—A Pilot Study |
title | Chitotriosidase and Neopterin as Potential Biomarkers for the Evaluation of Complicated Cholecystitis—A Pilot Study |
title_full | Chitotriosidase and Neopterin as Potential Biomarkers for the Evaluation of Complicated Cholecystitis—A Pilot Study |
title_fullStr | Chitotriosidase and Neopterin as Potential Biomarkers for the Evaluation of Complicated Cholecystitis—A Pilot Study |
title_full_unstemmed | Chitotriosidase and Neopterin as Potential Biomarkers for the Evaluation of Complicated Cholecystitis—A Pilot Study |
title_short | Chitotriosidase and Neopterin as Potential Biomarkers for the Evaluation of Complicated Cholecystitis—A Pilot Study |
title_sort | chitotriosidase and neopterin as potential biomarkers for the evaluation of complicated cholecystitis—a pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9964990/ https://www.ncbi.nlm.nih.gov/pubmed/36836175 http://dx.doi.org/10.3390/jcm12041641 |
work_keys_str_mv | AT nechitavladionut chitotriosidaseandneopterinaspotentialbiomarkersfortheevaluationofcomplicatedcholecystitisapilotstudy AT hajjarnadimal chitotriosidaseandneopterinaspotentialbiomarkersfortheevaluationofcomplicatedcholecystitisapilotstudy AT drugancristina chitotriosidaseandneopterinaspotentialbiomarkersfortheevaluationofcomplicatedcholecystitisapilotstudy AT catanacristinasorina chitotriosidaseandneopterinaspotentialbiomarkersfortheevaluationofcomplicatedcholecystitisapilotstudy AT moisemil chitotriosidaseandneopterinaspotentialbiomarkersfortheevaluationofcomplicatedcholecystitisapilotstudy AT nechitamihaelaancuta chitotriosidaseandneopterinaspotentialbiomarkersfortheevaluationofcomplicatedcholecystitisapilotstudy AT graurflorin chitotriosidaseandneopterinaspotentialbiomarkersfortheevaluationofcomplicatedcholecystitisapilotstudy |