Cargando…

Characterization and Quantification of Arsenic Species in Foodstuffs of Plant Origin by HPLC/ICP-MS

Arsenic is a well-known carcinogenic, mutagenic and toxic element and occurs in the environment both as inorganic arsenic (iAs) and organoarsenical compounds (oAsCs). Since the toxicity of arsenic compounds depends on their chemical form, the identification and determination of arsenic species are e...

Descripción completa

Detalles Bibliográficos
Autores principales: D’Amore, Teresa, Miedico, Oto, Pompa, Ciro, Preite, Chiara, Iammarino, Marco, Nardelli, Valeria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965120/
https://www.ncbi.nlm.nih.gov/pubmed/36836868
http://dx.doi.org/10.3390/life13020511
_version_ 1784896678468255744
author D’Amore, Teresa
Miedico, Oto
Pompa, Ciro
Preite, Chiara
Iammarino, Marco
Nardelli, Valeria
author_facet D’Amore, Teresa
Miedico, Oto
Pompa, Ciro
Preite, Chiara
Iammarino, Marco
Nardelli, Valeria
author_sort D’Amore, Teresa
collection PubMed
description Arsenic is a well-known carcinogenic, mutagenic and toxic element and occurs in the environment both as inorganic arsenic (iAs) and organoarsenical compounds (oAsCs). Since the toxicity of arsenic compounds depends on their chemical form, the identification and determination of arsenic species are essential. Recently, the European Food Safety Authority, following the European Commission request, published a report on chronic dietary exposure to iAs and recommended the development and validation of analytical methods with adequate sensitivity and refined extraction procedures for this determination. Moreover, the authority called upon new arsenic speciation data for complex food matrices such as seaweeds, grains and grain-based products. Looking at this context, an optimized, sensitive and fast analytical method using high performance liquid chromatography followed by inductively coupled plasma—mass spectrometry (HPLC/ICP-MS) was developed for the determination of iAs (sum of arsenite—As(III) and arsenate—As(V)) and the most relevant oAsCs, arsenobetaine, dimethylarsinic acid and monomethylarsonic acid. The method was validated with satisfactory results in terms of linearity, sensitivity, selectivity, precision, recovery, uncertainty, ruggedness and matrix effect, and then successfully applied for the analysis of several matrices, i.e., processed and unprocessed cereal and cereal products, fruits, vegetables, legumes, seaweeds, nuts and seeds. The results obtained indicate that not only seaweed and rice matrices but also many cereals, legumes and plant-based foods for infants and young children contain significant concentrations of iAs and oAsCs. These findings contribute to the data collection necessary to assess the role of these matrices in the total arsenic exposure and if specific maximum limits have to be established.
format Online
Article
Text
id pubmed-9965120
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99651202023-02-26 Characterization and Quantification of Arsenic Species in Foodstuffs of Plant Origin by HPLC/ICP-MS D’Amore, Teresa Miedico, Oto Pompa, Ciro Preite, Chiara Iammarino, Marco Nardelli, Valeria Life (Basel) Article Arsenic is a well-known carcinogenic, mutagenic and toxic element and occurs in the environment both as inorganic arsenic (iAs) and organoarsenical compounds (oAsCs). Since the toxicity of arsenic compounds depends on their chemical form, the identification and determination of arsenic species are essential. Recently, the European Food Safety Authority, following the European Commission request, published a report on chronic dietary exposure to iAs and recommended the development and validation of analytical methods with adequate sensitivity and refined extraction procedures for this determination. Moreover, the authority called upon new arsenic speciation data for complex food matrices such as seaweeds, grains and grain-based products. Looking at this context, an optimized, sensitive and fast analytical method using high performance liquid chromatography followed by inductively coupled plasma—mass spectrometry (HPLC/ICP-MS) was developed for the determination of iAs (sum of arsenite—As(III) and arsenate—As(V)) and the most relevant oAsCs, arsenobetaine, dimethylarsinic acid and monomethylarsonic acid. The method was validated with satisfactory results in terms of linearity, sensitivity, selectivity, precision, recovery, uncertainty, ruggedness and matrix effect, and then successfully applied for the analysis of several matrices, i.e., processed and unprocessed cereal and cereal products, fruits, vegetables, legumes, seaweeds, nuts and seeds. The results obtained indicate that not only seaweed and rice matrices but also many cereals, legumes and plant-based foods for infants and young children contain significant concentrations of iAs and oAsCs. These findings contribute to the data collection necessary to assess the role of these matrices in the total arsenic exposure and if specific maximum limits have to be established. MDPI 2023-02-12 /pmc/articles/PMC9965120/ /pubmed/36836868 http://dx.doi.org/10.3390/life13020511 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
D’Amore, Teresa
Miedico, Oto
Pompa, Ciro
Preite, Chiara
Iammarino, Marco
Nardelli, Valeria
Characterization and Quantification of Arsenic Species in Foodstuffs of Plant Origin by HPLC/ICP-MS
title Characterization and Quantification of Arsenic Species in Foodstuffs of Plant Origin by HPLC/ICP-MS
title_full Characterization and Quantification of Arsenic Species in Foodstuffs of Plant Origin by HPLC/ICP-MS
title_fullStr Characterization and Quantification of Arsenic Species in Foodstuffs of Plant Origin by HPLC/ICP-MS
title_full_unstemmed Characterization and Quantification of Arsenic Species in Foodstuffs of Plant Origin by HPLC/ICP-MS
title_short Characterization and Quantification of Arsenic Species in Foodstuffs of Plant Origin by HPLC/ICP-MS
title_sort characterization and quantification of arsenic species in foodstuffs of plant origin by hplc/icp-ms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965120/
https://www.ncbi.nlm.nih.gov/pubmed/36836868
http://dx.doi.org/10.3390/life13020511
work_keys_str_mv AT damoreteresa characterizationandquantificationofarsenicspeciesinfoodstuffsofplantoriginbyhplcicpms
AT miedicooto characterizationandquantificationofarsenicspeciesinfoodstuffsofplantoriginbyhplcicpms
AT pompaciro characterizationandquantificationofarsenicspeciesinfoodstuffsofplantoriginbyhplcicpms
AT preitechiara characterizationandquantificationofarsenicspeciesinfoodstuffsofplantoriginbyhplcicpms
AT iammarinomarco characterizationandquantificationofarsenicspeciesinfoodstuffsofplantoriginbyhplcicpms
AT nardellivaleria characterizationandquantificationofarsenicspeciesinfoodstuffsofplantoriginbyhplcicpms