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The Impact of Fluorination on the Design of Histone Deacetylase Inhibitors

In recent years, histone deacetylases (HDACs) have emerged as promising targets in the treatment of cancer. The approach is to inhibit HDACs with drugs known as HDAC inhibitors (HDACis). Such HDACis are broadly classified according to their chemical structure, e.g., hydroxamic acids, benzamides, thi...

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Detalles Bibliográficos
Autores principales: Tien Anh, Duong, Hai Nam, Nguyen, Kircher, Brigitte, Baecker, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965134/
https://www.ncbi.nlm.nih.gov/pubmed/36838960
http://dx.doi.org/10.3390/molecules28041973