Cargando…
Nanoscale Iron-Based Metal–Organic Frameworks: Incorporation of Functionalized Drugs and Degradation in Biological Media
Metal–organic frameworks (MOFs) attract growing interest in biomedical applications. Among thousands of MOF structures, the mesoporous iron(III) carboxylate MIL-100(Fe) (MIL stands for the Materials of Lavoisier Institute) is among the most studied MOF nanocarrier, owing to its high porosity, biodeg...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965190/ https://www.ncbi.nlm.nih.gov/pubmed/36834775 http://dx.doi.org/10.3390/ijms24043362 |
_version_ | 1784896696139907072 |
---|---|
author | Christodoulou, Ioanna Lyu, Pengbo Soares, Carla Vieira Patriarche, Gilles Serre, Christian Maurin, Guillaume Gref, Ruxandra |
author_facet | Christodoulou, Ioanna Lyu, Pengbo Soares, Carla Vieira Patriarche, Gilles Serre, Christian Maurin, Guillaume Gref, Ruxandra |
author_sort | Christodoulou, Ioanna |
collection | PubMed |
description | Metal–organic frameworks (MOFs) attract growing interest in biomedical applications. Among thousands of MOF structures, the mesoporous iron(III) carboxylate MIL-100(Fe) (MIL stands for the Materials of Lavoisier Institute) is among the most studied MOF nanocarrier, owing to its high porosity, biodegradability, and lack of toxicity. Nanosized MIL-100(Fe) particles (nanoMOFs) readily coordinate with drugs leading to unprecedented payloads and controlled release. Here, we show how the functional groups of the challenging anticancer drug prednisolone influence their interactions with the nanoMOFs and their release in various media. Molecular modeling enabled predicting the strength of interactions between prednisolone-bearing or not phosphate or sulfate moieties (PP and PS, respectively) and the oxo-trimer of MIL-100(Fe) as well as understanding the pore filling of MIL-100(Fe). Noticeably, PP showed the strongest interactions (drug loading up to 30 wt %, encapsulation efficiency > 98%) and slowed down the nanoMOFs’ degradation in simulated body fluid. This drug was shown to bind to the iron Lewis acid sites and was not displaced by other ions in the suspension media. On the contrary, PS was entrapped with lower efficiencies and was easily displaced by phosphates in the release media. Noticeably, the nanoMOFs maintained their size and faceted structures after drug loading and even after degradation in blood or serum after losing almost the totality of the constitutive trimesate ligands. Scanning electron microscopy with high annular dark field (STEM-HAADF) in conjunction with X-Ray energy-dispersive spectrometry (XEDS) was a powerful tool enabling the unraveling of the main elements to gain insights on the MOF structural evolution after drug loading and/or upon degradation. |
format | Online Article Text |
id | pubmed-9965190 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99651902023-02-26 Nanoscale Iron-Based Metal–Organic Frameworks: Incorporation of Functionalized Drugs and Degradation in Biological Media Christodoulou, Ioanna Lyu, Pengbo Soares, Carla Vieira Patriarche, Gilles Serre, Christian Maurin, Guillaume Gref, Ruxandra Int J Mol Sci Article Metal–organic frameworks (MOFs) attract growing interest in biomedical applications. Among thousands of MOF structures, the mesoporous iron(III) carboxylate MIL-100(Fe) (MIL stands for the Materials of Lavoisier Institute) is among the most studied MOF nanocarrier, owing to its high porosity, biodegradability, and lack of toxicity. Nanosized MIL-100(Fe) particles (nanoMOFs) readily coordinate with drugs leading to unprecedented payloads and controlled release. Here, we show how the functional groups of the challenging anticancer drug prednisolone influence their interactions with the nanoMOFs and their release in various media. Molecular modeling enabled predicting the strength of interactions between prednisolone-bearing or not phosphate or sulfate moieties (PP and PS, respectively) and the oxo-trimer of MIL-100(Fe) as well as understanding the pore filling of MIL-100(Fe). Noticeably, PP showed the strongest interactions (drug loading up to 30 wt %, encapsulation efficiency > 98%) and slowed down the nanoMOFs’ degradation in simulated body fluid. This drug was shown to bind to the iron Lewis acid sites and was not displaced by other ions in the suspension media. On the contrary, PS was entrapped with lower efficiencies and was easily displaced by phosphates in the release media. Noticeably, the nanoMOFs maintained their size and faceted structures after drug loading and even after degradation in blood or serum after losing almost the totality of the constitutive trimesate ligands. Scanning electron microscopy with high annular dark field (STEM-HAADF) in conjunction with X-Ray energy-dispersive spectrometry (XEDS) was a powerful tool enabling the unraveling of the main elements to gain insights on the MOF structural evolution after drug loading and/or upon degradation. MDPI 2023-02-08 /pmc/articles/PMC9965190/ /pubmed/36834775 http://dx.doi.org/10.3390/ijms24043362 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Christodoulou, Ioanna Lyu, Pengbo Soares, Carla Vieira Patriarche, Gilles Serre, Christian Maurin, Guillaume Gref, Ruxandra Nanoscale Iron-Based Metal–Organic Frameworks: Incorporation of Functionalized Drugs and Degradation in Biological Media |
title | Nanoscale Iron-Based Metal–Organic Frameworks: Incorporation of Functionalized Drugs and Degradation in Biological Media |
title_full | Nanoscale Iron-Based Metal–Organic Frameworks: Incorporation of Functionalized Drugs and Degradation in Biological Media |
title_fullStr | Nanoscale Iron-Based Metal–Organic Frameworks: Incorporation of Functionalized Drugs and Degradation in Biological Media |
title_full_unstemmed | Nanoscale Iron-Based Metal–Organic Frameworks: Incorporation of Functionalized Drugs and Degradation in Biological Media |
title_short | Nanoscale Iron-Based Metal–Organic Frameworks: Incorporation of Functionalized Drugs and Degradation in Biological Media |
title_sort | nanoscale iron-based metal–organic frameworks: incorporation of functionalized drugs and degradation in biological media |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965190/ https://www.ncbi.nlm.nih.gov/pubmed/36834775 http://dx.doi.org/10.3390/ijms24043362 |
work_keys_str_mv | AT christodoulouioanna nanoscaleironbasedmetalorganicframeworksincorporationoffunctionalizeddrugsanddegradationinbiologicalmedia AT lyupengbo nanoscaleironbasedmetalorganicframeworksincorporationoffunctionalizeddrugsanddegradationinbiologicalmedia AT soarescarlavieira nanoscaleironbasedmetalorganicframeworksincorporationoffunctionalizeddrugsanddegradationinbiologicalmedia AT patriarchegilles nanoscaleironbasedmetalorganicframeworksincorporationoffunctionalizeddrugsanddegradationinbiologicalmedia AT serrechristian nanoscaleironbasedmetalorganicframeworksincorporationoffunctionalizeddrugsanddegradationinbiologicalmedia AT mauringuillaume nanoscaleironbasedmetalorganicframeworksincorporationoffunctionalizeddrugsanddegradationinbiologicalmedia AT grefruxandra nanoscaleironbasedmetalorganicframeworksincorporationoffunctionalizeddrugsanddegradationinbiologicalmedia |