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Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications
Recent studies in experimental animals found that oral exposure to micro- and nano-plastics (MNPs) during pregnancy had multiple adverse effects on outcomes and progeny, although no study has yet identified the translocation of ingested MNPs to the placenta or fetal tissues, which might account for...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965230/ https://www.ncbi.nlm.nih.gov/pubmed/36839088 http://dx.doi.org/10.3390/nano13040720 |
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author | Cary, Chelsea M. DeLoid, Glen M. Yang, Zhenning Bitounis, Dimitrios Polunas, Marianne Goedken, Michael J. Buckley, Brian Cheatham, Byron Stapleton, Phoebe A. Demokritou, Philip |
author_facet | Cary, Chelsea M. DeLoid, Glen M. Yang, Zhenning Bitounis, Dimitrios Polunas, Marianne Goedken, Michael J. Buckley, Brian Cheatham, Byron Stapleton, Phoebe A. Demokritou, Philip |
author_sort | Cary, Chelsea M. |
collection | PubMed |
description | Recent studies in experimental animals found that oral exposure to micro- and nano-plastics (MNPs) during pregnancy had multiple adverse effects on outcomes and progeny, although no study has yet identified the translocation of ingested MNPs to the placenta or fetal tissues, which might account for those effects. We therefore assessed the placental and fetal translocation of ingested nanoscale polystyrene MNPs in pregnant rats. Sprague Dawley rats (N = 5) were gavaged on gestational day 19 with 10 mL/kg of 250 µg/mL 25 nm carboxylated polystyrene spheres (PS25C) and sacrificed after 24 h. Hyperspectral imaging of harvested placental and fetal tissues identified abundant PS25C within the placenta and in all fetal tissues examined, including liver, kidney, heart, lung and brain, where they appeared in 10–25 µm clusters. These findings demonstrate that ingested nanoscale polystyrene MNPs can breach the intestinal barrier and subsequently the maternal–fetal barrier of the placenta to access the fetal circulation and all fetal tissues. Further studies are needed to assess the mechanisms of MNP translocation across the intestinal and placental barriers, the effects of MNP polymer, size and other physicochemical properties on translocation, as well as the potential adverse effects of MNP translocation on the developing fetus. |
format | Online Article Text |
id | pubmed-9965230 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99652302023-02-26 Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications Cary, Chelsea M. DeLoid, Glen M. Yang, Zhenning Bitounis, Dimitrios Polunas, Marianne Goedken, Michael J. Buckley, Brian Cheatham, Byron Stapleton, Phoebe A. Demokritou, Philip Nanomaterials (Basel) Article Recent studies in experimental animals found that oral exposure to micro- and nano-plastics (MNPs) during pregnancy had multiple adverse effects on outcomes and progeny, although no study has yet identified the translocation of ingested MNPs to the placenta or fetal tissues, which might account for those effects. We therefore assessed the placental and fetal translocation of ingested nanoscale polystyrene MNPs in pregnant rats. Sprague Dawley rats (N = 5) were gavaged on gestational day 19 with 10 mL/kg of 250 µg/mL 25 nm carboxylated polystyrene spheres (PS25C) and sacrificed after 24 h. Hyperspectral imaging of harvested placental and fetal tissues identified abundant PS25C within the placenta and in all fetal tissues examined, including liver, kidney, heart, lung and brain, where they appeared in 10–25 µm clusters. These findings demonstrate that ingested nanoscale polystyrene MNPs can breach the intestinal barrier and subsequently the maternal–fetal barrier of the placenta to access the fetal circulation and all fetal tissues. Further studies are needed to assess the mechanisms of MNP translocation across the intestinal and placental barriers, the effects of MNP polymer, size and other physicochemical properties on translocation, as well as the potential adverse effects of MNP translocation on the developing fetus. MDPI 2023-02-14 /pmc/articles/PMC9965230/ /pubmed/36839088 http://dx.doi.org/10.3390/nano13040720 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cary, Chelsea M. DeLoid, Glen M. Yang, Zhenning Bitounis, Dimitrios Polunas, Marianne Goedken, Michael J. Buckley, Brian Cheatham, Byron Stapleton, Phoebe A. Demokritou, Philip Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications |
title | Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications |
title_full | Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications |
title_fullStr | Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications |
title_full_unstemmed | Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications |
title_short | Ingested Polystyrene Nanospheres Translocate to Placenta and Fetal Tissues in Pregnant Rats: Potential Health Implications |
title_sort | ingested polystyrene nanospheres translocate to placenta and fetal tissues in pregnant rats: potential health implications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965230/ https://www.ncbi.nlm.nih.gov/pubmed/36839088 http://dx.doi.org/10.3390/nano13040720 |
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