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Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story

Atherosclerotic cardiovascular disease is the most common cause of morbidity and mortality worldwide. Diabetes mellitus increases cardiovascular risk. Heart failure and atrial fibrillation are associated comorbidities that share the main cardiovascular risk factors. The use of incretin-based therapi...

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Autores principales: Inceu, Andreea-Ioana, Neag, Maria-Adriana, Craciun, Anca-Elena, Buzoianu, Anca-Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965280/
https://www.ncbi.nlm.nih.gov/pubmed/36834796
http://dx.doi.org/10.3390/ijms24043385
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author Inceu, Andreea-Ioana
Neag, Maria-Adriana
Craciun, Anca-Elena
Buzoianu, Anca-Dana
author_facet Inceu, Andreea-Ioana
Neag, Maria-Adriana
Craciun, Anca-Elena
Buzoianu, Anca-Dana
author_sort Inceu, Andreea-Ioana
collection PubMed
description Atherosclerotic cardiovascular disease is the most common cause of morbidity and mortality worldwide. Diabetes mellitus increases cardiovascular risk. Heart failure and atrial fibrillation are associated comorbidities that share the main cardiovascular risk factors. The use of incretin-based therapies promoted the idea that activation of alternative signaling pathways is effective in reducing the risk of atherosclerosis and heart failure. Gut-derived molecules, gut hormones, and gut microbiota metabolites showed both positive and detrimental effects in cardiometabolic disorders. Although inflammation plays a key role in cardiometabolic disorders, additional intracellular signaling pathways are involved and could explain the observed effects. Revealing the involved molecular mechanisms could provide novel therapeutic strategies and a better understanding of the relationship between the gut, metabolic syndrome, and cardiovascular diseases.
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spelling pubmed-99652802023-02-26 Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story Inceu, Andreea-Ioana Neag, Maria-Adriana Craciun, Anca-Elena Buzoianu, Anca-Dana Int J Mol Sci Review Atherosclerotic cardiovascular disease is the most common cause of morbidity and mortality worldwide. Diabetes mellitus increases cardiovascular risk. Heart failure and atrial fibrillation are associated comorbidities that share the main cardiovascular risk factors. The use of incretin-based therapies promoted the idea that activation of alternative signaling pathways is effective in reducing the risk of atherosclerosis and heart failure. Gut-derived molecules, gut hormones, and gut microbiota metabolites showed both positive and detrimental effects in cardiometabolic disorders. Although inflammation plays a key role in cardiometabolic disorders, additional intracellular signaling pathways are involved and could explain the observed effects. Revealing the involved molecular mechanisms could provide novel therapeutic strategies and a better understanding of the relationship between the gut, metabolic syndrome, and cardiovascular diseases. MDPI 2023-02-08 /pmc/articles/PMC9965280/ /pubmed/36834796 http://dx.doi.org/10.3390/ijms24043385 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Inceu, Andreea-Ioana
Neag, Maria-Adriana
Craciun, Anca-Elena
Buzoianu, Anca-Dana
Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story
title Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story
title_full Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story
title_fullStr Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story
title_full_unstemmed Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story
title_short Gut Molecules in Cardiometabolic Diseases: The Mechanisms behind the Story
title_sort gut molecules in cardiometabolic diseases: the mechanisms behind the story
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965280/
https://www.ncbi.nlm.nih.gov/pubmed/36834796
http://dx.doi.org/10.3390/ijms24043385
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