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Gut-Microbiota, and Multiple Sclerosis: Background, Evidence, and Perspectives

Many scientific studies reveal a significant connection between human intestinal microbiota, eating habits, and the development of chronic-degenerative diseases; therefore, alterations in the composition and function of the microbiota may be accompanied by different chronic inflammatory mechanisms....

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Autores principales: Altieri, Clelia, Speranza, Barbara, Corbo, Maria Rosaria, Sinigaglia, Milena, Bevilacqua, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965298/
https://www.ncbi.nlm.nih.gov/pubmed/36839299
http://dx.doi.org/10.3390/nu15040942
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author Altieri, Clelia
Speranza, Barbara
Corbo, Maria Rosaria
Sinigaglia, Milena
Bevilacqua, Antonio
author_facet Altieri, Clelia
Speranza, Barbara
Corbo, Maria Rosaria
Sinigaglia, Milena
Bevilacqua, Antonio
author_sort Altieri, Clelia
collection PubMed
description Many scientific studies reveal a significant connection between human intestinal microbiota, eating habits, and the development of chronic-degenerative diseases; therefore, alterations in the composition and function of the microbiota may be accompanied by different chronic inflammatory mechanisms. Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS), in which autoreactive immune cells attack the myelin sheaths of the neurons. The purpose of this paper was to describe the main changes that occur in the gut microbiota of MS patients, with a focus on both microbiota and its implications for health and disease, as well as the variables that influence it. Another point stressed by this paper is the role of microbiota as a triggering factor to modulate the responses of the innate and adaptive immune systems, both in the intestine and in the brain. In addition, a comprehensive overview of the taxa modified by the disease is presented, with some points on microbiota modulation as a therapeutic approach for MS. Finally, the significance of gastro-intestinal pains (indirectly related to dysbiosis) was assessed using a case study (questionnaire for MS patients), as was the willingness of MS patients to modulate gut microbiota with probiotics.
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spelling pubmed-99652982023-02-26 Gut-Microbiota, and Multiple Sclerosis: Background, Evidence, and Perspectives Altieri, Clelia Speranza, Barbara Corbo, Maria Rosaria Sinigaglia, Milena Bevilacqua, Antonio Nutrients Review Many scientific studies reveal a significant connection between human intestinal microbiota, eating habits, and the development of chronic-degenerative diseases; therefore, alterations in the composition and function of the microbiota may be accompanied by different chronic inflammatory mechanisms. Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS), in which autoreactive immune cells attack the myelin sheaths of the neurons. The purpose of this paper was to describe the main changes that occur in the gut microbiota of MS patients, with a focus on both microbiota and its implications for health and disease, as well as the variables that influence it. Another point stressed by this paper is the role of microbiota as a triggering factor to modulate the responses of the innate and adaptive immune systems, both in the intestine and in the brain. In addition, a comprehensive overview of the taxa modified by the disease is presented, with some points on microbiota modulation as a therapeutic approach for MS. Finally, the significance of gastro-intestinal pains (indirectly related to dysbiosis) was assessed using a case study (questionnaire for MS patients), as was the willingness of MS patients to modulate gut microbiota with probiotics. MDPI 2023-02-14 /pmc/articles/PMC9965298/ /pubmed/36839299 http://dx.doi.org/10.3390/nu15040942 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Altieri, Clelia
Speranza, Barbara
Corbo, Maria Rosaria
Sinigaglia, Milena
Bevilacqua, Antonio
Gut-Microbiota, and Multiple Sclerosis: Background, Evidence, and Perspectives
title Gut-Microbiota, and Multiple Sclerosis: Background, Evidence, and Perspectives
title_full Gut-Microbiota, and Multiple Sclerosis: Background, Evidence, and Perspectives
title_fullStr Gut-Microbiota, and Multiple Sclerosis: Background, Evidence, and Perspectives
title_full_unstemmed Gut-Microbiota, and Multiple Sclerosis: Background, Evidence, and Perspectives
title_short Gut-Microbiota, and Multiple Sclerosis: Background, Evidence, and Perspectives
title_sort gut-microbiota, and multiple sclerosis: background, evidence, and perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965298/
https://www.ncbi.nlm.nih.gov/pubmed/36839299
http://dx.doi.org/10.3390/nu15040942
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