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Insect Cell-Based Models: Cell Line Establishment and Application in Insecticide Screening and Toxicology Research

SIMPLE SUMMARY: Insect cell lines have often been employed in pest management, where they have been used as tools to evaluate the activity and explore the toxic mechanisms of insecticide candidate compounds. This review summarizes the progression of insect cell line establishment, then introduces se...

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Autores principales: He, Xuan, Lu, Lidan, Huang, Ping, Yu, Bo, Peng, Lianxin, Zou, Liang, Ren, Yuanhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965340/
https://www.ncbi.nlm.nih.gov/pubmed/36835673
http://dx.doi.org/10.3390/insects14020104
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author He, Xuan
Lu, Lidan
Huang, Ping
Yu, Bo
Peng, Lianxin
Zou, Liang
Ren, Yuanhang
author_facet He, Xuan
Lu, Lidan
Huang, Ping
Yu, Bo
Peng, Lianxin
Zou, Liang
Ren, Yuanhang
author_sort He, Xuan
collection PubMed
description SIMPLE SUMMARY: Insect cell lines have often been employed in pest management, where they have been used as tools to evaluate the activity and explore the toxic mechanisms of insecticide candidate compounds. This review summarizes the progression of insect cell line establishment, then introduces several recent studies based on insect cell lines coupled with advanced technologies. These cell-based studies could increase efficiency and reduce the cost of insecticide studies, providing a global and in-depth perspective to reveal and verify the mode of action of insecticides. ABSTRACT: During the past decades, research on insect cell culture has grown tremendously. Thousands of lines have been established from different species of insect orders, originating from several tissue sources. These cell lines have often been employed in insect science research. In particular, they have played important roles in pest management, where they have been used as tools to evaluate the activity and explore the toxic mechanisms of insecticide candidate compounds. This review intends to first briefly summarize the progression of insect cell line establishment. Then, several recent studies based on insect cell lines coupled with advanced technologies are introduced. These investigations revealed that insect cell lines can be exploited as novel models with unique advantages such as increased efficiency and reduced cost compared with traditional insecticide research. Most notably, the insect cell line-based models provide a global and in-depth perspective to study the toxicology mechanisms of insecticides. However, challenges and limitations still exist, especially in the connection between in vitro activity and in vivo effectiveness. Despite all this, recent advances have suggested that insect cell line-based models promote the progress and sensible application of insecticides, which benefits pest management.
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spelling pubmed-99653402023-02-26 Insect Cell-Based Models: Cell Line Establishment and Application in Insecticide Screening and Toxicology Research He, Xuan Lu, Lidan Huang, Ping Yu, Bo Peng, Lianxin Zou, Liang Ren, Yuanhang Insects Review SIMPLE SUMMARY: Insect cell lines have often been employed in pest management, where they have been used as tools to evaluate the activity and explore the toxic mechanisms of insecticide candidate compounds. This review summarizes the progression of insect cell line establishment, then introduces several recent studies based on insect cell lines coupled with advanced technologies. These cell-based studies could increase efficiency and reduce the cost of insecticide studies, providing a global and in-depth perspective to reveal and verify the mode of action of insecticides. ABSTRACT: During the past decades, research on insect cell culture has grown tremendously. Thousands of lines have been established from different species of insect orders, originating from several tissue sources. These cell lines have often been employed in insect science research. In particular, they have played important roles in pest management, where they have been used as tools to evaluate the activity and explore the toxic mechanisms of insecticide candidate compounds. This review intends to first briefly summarize the progression of insect cell line establishment. Then, several recent studies based on insect cell lines coupled with advanced technologies are introduced. These investigations revealed that insect cell lines can be exploited as novel models with unique advantages such as increased efficiency and reduced cost compared with traditional insecticide research. Most notably, the insect cell line-based models provide a global and in-depth perspective to study the toxicology mechanisms of insecticides. However, challenges and limitations still exist, especially in the connection between in vitro activity and in vivo effectiveness. Despite all this, recent advances have suggested that insect cell line-based models promote the progress and sensible application of insecticides, which benefits pest management. MDPI 2023-01-18 /pmc/articles/PMC9965340/ /pubmed/36835673 http://dx.doi.org/10.3390/insects14020104 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
He, Xuan
Lu, Lidan
Huang, Ping
Yu, Bo
Peng, Lianxin
Zou, Liang
Ren, Yuanhang
Insect Cell-Based Models: Cell Line Establishment and Application in Insecticide Screening and Toxicology Research
title Insect Cell-Based Models: Cell Line Establishment and Application in Insecticide Screening and Toxicology Research
title_full Insect Cell-Based Models: Cell Line Establishment and Application in Insecticide Screening and Toxicology Research
title_fullStr Insect Cell-Based Models: Cell Line Establishment and Application in Insecticide Screening and Toxicology Research
title_full_unstemmed Insect Cell-Based Models: Cell Line Establishment and Application in Insecticide Screening and Toxicology Research
title_short Insect Cell-Based Models: Cell Line Establishment and Application in Insecticide Screening and Toxicology Research
title_sort insect cell-based models: cell line establishment and application in insecticide screening and toxicology research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965340/
https://www.ncbi.nlm.nih.gov/pubmed/36835673
http://dx.doi.org/10.3390/insects14020104
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