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Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges
New nanotechnologies for imaging molecules are widely being applied to visualize the expression of specific molecules (e.g., ions, biomarkers) for disease diagnosis. Among various nanoplatforms, nanozymes, which exhibit enzyme-like catalytic activities in vivo, have gained tremendously increasing at...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965384/ https://www.ncbi.nlm.nih.gov/pubmed/37259396 http://dx.doi.org/10.3390/ph16020249 |
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author | Luo, Qiao Shao, Ni Zhang, Ai-Chen Chen, Chun-Fang Wang, Duo Luo, Liang-Ping Xiao, Ze-Yu |
author_facet | Luo, Qiao Shao, Ni Zhang, Ai-Chen Chen, Chun-Fang Wang, Duo Luo, Liang-Ping Xiao, Ze-Yu |
author_sort | Luo, Qiao |
collection | PubMed |
description | New nanotechnologies for imaging molecules are widely being applied to visualize the expression of specific molecules (e.g., ions, biomarkers) for disease diagnosis. Among various nanoplatforms, nanozymes, which exhibit enzyme-like catalytic activities in vivo, have gained tremendously increasing attention in molecular imaging due to their unique properties such as diverse enzyme-mimicking activities, excellent biocompatibility, ease of surface tenability, and low cost. In addition, by integrating different nanoparticles with superparamagnetic, photoacoustic, fluorescence, and photothermal properties, the nanoenzymes are able to increase the imaging sensitivity and accuracy for better understanding the complexity and the biological process of disease. Moreover, these functions encourage the utilization of nanozymes as therapeutic agents to assist in treatment. In this review, we focus on the applications of nanozymes in molecular imaging and discuss the use of peroxidase (POD), oxidase (OXD), catalase (CAT), and superoxide dismutase (SOD) with different imaging modalities. Further, the applications of nanozymes for cancer treatment, bacterial infection, and inflammation image-guided therapy are discussed. Overall, this review aims to provide a complete reference for research in the interdisciplinary fields of nanotechnology and molecular imaging to promote the advancement and clinical translation of novel biomimetic nanozymes. |
format | Online Article Text |
id | pubmed-9965384 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99653842023-02-26 Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges Luo, Qiao Shao, Ni Zhang, Ai-Chen Chen, Chun-Fang Wang, Duo Luo, Liang-Ping Xiao, Ze-Yu Pharmaceuticals (Basel) Review New nanotechnologies for imaging molecules are widely being applied to visualize the expression of specific molecules (e.g., ions, biomarkers) for disease diagnosis. Among various nanoplatforms, nanozymes, which exhibit enzyme-like catalytic activities in vivo, have gained tremendously increasing attention in molecular imaging due to their unique properties such as diverse enzyme-mimicking activities, excellent biocompatibility, ease of surface tenability, and low cost. In addition, by integrating different nanoparticles with superparamagnetic, photoacoustic, fluorescence, and photothermal properties, the nanoenzymes are able to increase the imaging sensitivity and accuracy for better understanding the complexity and the biological process of disease. Moreover, these functions encourage the utilization of nanozymes as therapeutic agents to assist in treatment. In this review, we focus on the applications of nanozymes in molecular imaging and discuss the use of peroxidase (POD), oxidase (OXD), catalase (CAT), and superoxide dismutase (SOD) with different imaging modalities. Further, the applications of nanozymes for cancer treatment, bacterial infection, and inflammation image-guided therapy are discussed. Overall, this review aims to provide a complete reference for research in the interdisciplinary fields of nanotechnology and molecular imaging to promote the advancement and clinical translation of novel biomimetic nanozymes. MDPI 2023-02-07 /pmc/articles/PMC9965384/ /pubmed/37259396 http://dx.doi.org/10.3390/ph16020249 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Luo, Qiao Shao, Ni Zhang, Ai-Chen Chen, Chun-Fang Wang, Duo Luo, Liang-Ping Xiao, Ze-Yu Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges |
title | Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges |
title_full | Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges |
title_fullStr | Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges |
title_full_unstemmed | Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges |
title_short | Smart Biomimetic Nanozymes for Precise Molecular Imaging: Application and Challenges |
title_sort | smart biomimetic nanozymes for precise molecular imaging: application and challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965384/ https://www.ncbi.nlm.nih.gov/pubmed/37259396 http://dx.doi.org/10.3390/ph16020249 |
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