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Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms

(1) Background: Obesity and its comorbidities can cause burdens and limitations. Bariatric surgery (BS) is indicated as a safe procedure to reduce body mass and improve present comorbidities. However, several complications were reported, such as vitamin D [25(OH)D] deficiency. We evaluated if 25(OH)...

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Autores principales: Benito, Linconl Agudo Oliveira, Kogawa, Evelyn Mikaela, Silva, Calliandra Maria de Souza, Melo, Fabíola Ferreira, Sales-Peres, Silvia Helena de Carvalho, da Silva, Izabel Cristina Rodrigues, de Oliveira Karnikowski, Margô Gomes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965411/
https://www.ncbi.nlm.nih.gov/pubmed/36839157
http://dx.doi.org/10.3390/nu15040799
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author Benito, Linconl Agudo Oliveira
Kogawa, Evelyn Mikaela
Silva, Calliandra Maria de Souza
Melo, Fabíola Ferreira
Sales-Peres, Silvia Helena de Carvalho
da Silva, Izabel Cristina Rodrigues
de Oliveira Karnikowski, Margô Gomes
author_facet Benito, Linconl Agudo Oliveira
Kogawa, Evelyn Mikaela
Silva, Calliandra Maria de Souza
Melo, Fabíola Ferreira
Sales-Peres, Silvia Helena de Carvalho
da Silva, Izabel Cristina Rodrigues
de Oliveira Karnikowski, Margô Gomes
author_sort Benito, Linconl Agudo Oliveira
collection PubMed
description (1) Background: Obesity and its comorbidities can cause burdens and limitations. Bariatric surgery (BS) is indicated as a safe procedure to reduce body mass and improve present comorbidities. However, several complications were reported, such as vitamin D [25(OH)D] deficiency. We evaluated if 25(OH)D serum levels relate to clinical characteristics, symptoms, or habits in women after their BS, and whether the vitamin D receptor (VDR) gene’s TaqI and FokI polymorphisms affected 25(OH)D levels and the total body bone mineral density (TBBMD). (2) Methods: This cohort cross-sectional comparative analytical prospective study consisted of 27 women, 61.6 ± 5.0 years, submitted to BS one year prior at a public reference hospital, DF-Brazil. All participants were asked to follow the physical and dietary activity recommendations and received vitamin D3 supplements. Their anthropometric, biochemical, and immunological measurements and blood samples were obtained. (3) Results: 73.3% of participants had low 25(OH)D levels, and their levels correlated positively with TBBMD and negatively with systolic pressure. VDR TaqI did not affect 25(OH)D levels, whereas VDR FokI’s allele f presence correlated to a median rise in 25(OH)D levels. Neither polymorphism correlated to TBBMD. (4) Conclusions: 25(OH)D levels were positively correlated with TBBMD, negatively with systolic blood pressure, and were higher in those with the VDR FokI allele f.
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spelling pubmed-99654112023-02-26 Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms Benito, Linconl Agudo Oliveira Kogawa, Evelyn Mikaela Silva, Calliandra Maria de Souza Melo, Fabíola Ferreira Sales-Peres, Silvia Helena de Carvalho da Silva, Izabel Cristina Rodrigues de Oliveira Karnikowski, Margô Gomes Nutrients Article (1) Background: Obesity and its comorbidities can cause burdens and limitations. Bariatric surgery (BS) is indicated as a safe procedure to reduce body mass and improve present comorbidities. However, several complications were reported, such as vitamin D [25(OH)D] deficiency. We evaluated if 25(OH)D serum levels relate to clinical characteristics, symptoms, or habits in women after their BS, and whether the vitamin D receptor (VDR) gene’s TaqI and FokI polymorphisms affected 25(OH)D levels and the total body bone mineral density (TBBMD). (2) Methods: This cohort cross-sectional comparative analytical prospective study consisted of 27 women, 61.6 ± 5.0 years, submitted to BS one year prior at a public reference hospital, DF-Brazil. All participants were asked to follow the physical and dietary activity recommendations and received vitamin D3 supplements. Their anthropometric, biochemical, and immunological measurements and blood samples were obtained. (3) Results: 73.3% of participants had low 25(OH)D levels, and their levels correlated positively with TBBMD and negatively with systolic pressure. VDR TaqI did not affect 25(OH)D levels, whereas VDR FokI’s allele f presence correlated to a median rise in 25(OH)D levels. Neither polymorphism correlated to TBBMD. (4) Conclusions: 25(OH)D levels were positively correlated with TBBMD, negatively with systolic blood pressure, and were higher in those with the VDR FokI allele f. MDPI 2023-02-04 /pmc/articles/PMC9965411/ /pubmed/36839157 http://dx.doi.org/10.3390/nu15040799 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Benito, Linconl Agudo Oliveira
Kogawa, Evelyn Mikaela
Silva, Calliandra Maria de Souza
Melo, Fabíola Ferreira
Sales-Peres, Silvia Helena de Carvalho
da Silva, Izabel Cristina Rodrigues
de Oliveira Karnikowski, Margô Gomes
Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms
title Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms
title_full Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms
title_fullStr Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms
title_full_unstemmed Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms
title_short Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms
title_sort bariatric surgery and vitamin d: trends in older women and association with clinical features and vdr gene polymorphisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965411/
https://www.ncbi.nlm.nih.gov/pubmed/36839157
http://dx.doi.org/10.3390/nu15040799
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