Cargando…
Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study
The relationship between skeletal muscle and cognitive disorders has drawn increasing attention. This study aims to examine the associations of sarcopenia with cognitive function and dementia risk score. Data on 1978 participants (aged 65 years and older) from the 2011 wave of the China Health and R...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965467/ https://www.ncbi.nlm.nih.gov/pubmed/36837864 http://dx.doi.org/10.3390/metabo13020245 |
_version_ | 1784896771035496448 |
---|---|
author | Lin, Ailing Wang, Ting Li, Chenxi Pu, Fan Abdelrahman, Zeinab Jin, Mengqi Yang, Zhenqing Zhang, Liming Cao, Xingqi Sun, Kaili Hou, Tongyao Liu, Zuyun Chen, Liying Chen, Zuobing |
author_facet | Lin, Ailing Wang, Ting Li, Chenxi Pu, Fan Abdelrahman, Zeinab Jin, Mengqi Yang, Zhenqing Zhang, Liming Cao, Xingqi Sun, Kaili Hou, Tongyao Liu, Zuyun Chen, Liying Chen, Zuobing |
author_sort | Lin, Ailing |
collection | PubMed |
description | The relationship between skeletal muscle and cognitive disorders has drawn increasing attention. This study aims to examine the associations of sarcopenia with cognitive function and dementia risk score. Data on 1978 participants (aged 65 years and older) from the 2011 wave of the China Health and Retirement Longitudinal Study, with four follow-up waves to 2018, were used. Cognitive function was assessed by four dimensions, with a lower score indicating lower cognitive function. Dementia risk was assessed by a risk score using the Rotterdam Study Basic Dementia Risk Model (BDRM), with a higher score indicating a greater risk. Sarcopenia was defined when low muscle mass plus low muscle strength or low physical performance were met. We used generalized estimating equations to examine the associations of sarcopenia. In the fully adjusted models, sarcopenia was significantly associated with lower cognitive function (standardized, β = −0.15; 95% CIs: −0.26, −0.04) and a higher BDRM score (standardized, β = 0.42; 95% CIs: 0.29, 0.55). Our findings may provide a new avenue for alleviating the burden of cognitive disorders by preventing sarcopenia. |
format | Online Article Text |
id | pubmed-9965467 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99654672023-02-26 Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study Lin, Ailing Wang, Ting Li, Chenxi Pu, Fan Abdelrahman, Zeinab Jin, Mengqi Yang, Zhenqing Zhang, Liming Cao, Xingqi Sun, Kaili Hou, Tongyao Liu, Zuyun Chen, Liying Chen, Zuobing Metabolites Article The relationship between skeletal muscle and cognitive disorders has drawn increasing attention. This study aims to examine the associations of sarcopenia with cognitive function and dementia risk score. Data on 1978 participants (aged 65 years and older) from the 2011 wave of the China Health and Retirement Longitudinal Study, with four follow-up waves to 2018, were used. Cognitive function was assessed by four dimensions, with a lower score indicating lower cognitive function. Dementia risk was assessed by a risk score using the Rotterdam Study Basic Dementia Risk Model (BDRM), with a higher score indicating a greater risk. Sarcopenia was defined when low muscle mass plus low muscle strength or low physical performance were met. We used generalized estimating equations to examine the associations of sarcopenia. In the fully adjusted models, sarcopenia was significantly associated with lower cognitive function (standardized, β = −0.15; 95% CIs: −0.26, −0.04) and a higher BDRM score (standardized, β = 0.42; 95% CIs: 0.29, 0.55). Our findings may provide a new avenue for alleviating the burden of cognitive disorders by preventing sarcopenia. MDPI 2023-02-08 /pmc/articles/PMC9965467/ /pubmed/36837864 http://dx.doi.org/10.3390/metabo13020245 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lin, Ailing Wang, Ting Li, Chenxi Pu, Fan Abdelrahman, Zeinab Jin, Mengqi Yang, Zhenqing Zhang, Liming Cao, Xingqi Sun, Kaili Hou, Tongyao Liu, Zuyun Chen, Liying Chen, Zuobing Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study |
title | Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study |
title_full | Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study |
title_fullStr | Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study |
title_full_unstemmed | Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study |
title_short | Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study |
title_sort | association of sarcopenia with cognitive function and dementia risk score: a national prospective cohort study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965467/ https://www.ncbi.nlm.nih.gov/pubmed/36837864 http://dx.doi.org/10.3390/metabo13020245 |
work_keys_str_mv | AT linailing associationofsarcopeniawithcognitivefunctionanddementiariskscoreanationalprospectivecohortstudy AT wangting associationofsarcopeniawithcognitivefunctionanddementiariskscoreanationalprospectivecohortstudy AT lichenxi associationofsarcopeniawithcognitivefunctionanddementiariskscoreanationalprospectivecohortstudy AT pufan associationofsarcopeniawithcognitivefunctionanddementiariskscoreanationalprospectivecohortstudy AT abdelrahmanzeinab associationofsarcopeniawithcognitivefunctionanddementiariskscoreanationalprospectivecohortstudy AT jinmengqi associationofsarcopeniawithcognitivefunctionanddementiariskscoreanationalprospectivecohortstudy AT yangzhenqing associationofsarcopeniawithcognitivefunctionanddementiariskscoreanationalprospectivecohortstudy AT zhangliming associationofsarcopeniawithcognitivefunctionanddementiariskscoreanationalprospectivecohortstudy AT caoxingqi associationofsarcopeniawithcognitivefunctionanddementiariskscoreanationalprospectivecohortstudy AT sunkaili associationofsarcopeniawithcognitivefunctionanddementiariskscoreanationalprospectivecohortstudy AT houtongyao associationofsarcopeniawithcognitivefunctionanddementiariskscoreanationalprospectivecohortstudy AT liuzuyun associationofsarcopeniawithcognitivefunctionanddementiariskscoreanationalprospectivecohortstudy AT chenliying associationofsarcopeniawithcognitivefunctionanddementiariskscoreanationalprospectivecohortstudy AT chenzuobing associationofsarcopeniawithcognitivefunctionanddementiariskscoreanationalprospectivecohortstudy |