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Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study

The relationship between skeletal muscle and cognitive disorders has drawn increasing attention. This study aims to examine the associations of sarcopenia with cognitive function and dementia risk score. Data on 1978 participants (aged 65 years and older) from the 2011 wave of the China Health and R...

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Autores principales: Lin, Ailing, Wang, Ting, Li, Chenxi, Pu, Fan, Abdelrahman, Zeinab, Jin, Mengqi, Yang, Zhenqing, Zhang, Liming, Cao, Xingqi, Sun, Kaili, Hou, Tongyao, Liu, Zuyun, Chen, Liying, Chen, Zuobing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965467/
https://www.ncbi.nlm.nih.gov/pubmed/36837864
http://dx.doi.org/10.3390/metabo13020245
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author Lin, Ailing
Wang, Ting
Li, Chenxi
Pu, Fan
Abdelrahman, Zeinab
Jin, Mengqi
Yang, Zhenqing
Zhang, Liming
Cao, Xingqi
Sun, Kaili
Hou, Tongyao
Liu, Zuyun
Chen, Liying
Chen, Zuobing
author_facet Lin, Ailing
Wang, Ting
Li, Chenxi
Pu, Fan
Abdelrahman, Zeinab
Jin, Mengqi
Yang, Zhenqing
Zhang, Liming
Cao, Xingqi
Sun, Kaili
Hou, Tongyao
Liu, Zuyun
Chen, Liying
Chen, Zuobing
author_sort Lin, Ailing
collection PubMed
description The relationship between skeletal muscle and cognitive disorders has drawn increasing attention. This study aims to examine the associations of sarcopenia with cognitive function and dementia risk score. Data on 1978 participants (aged 65 years and older) from the 2011 wave of the China Health and Retirement Longitudinal Study, with four follow-up waves to 2018, were used. Cognitive function was assessed by four dimensions, with a lower score indicating lower cognitive function. Dementia risk was assessed by a risk score using the Rotterdam Study Basic Dementia Risk Model (BDRM), with a higher score indicating a greater risk. Sarcopenia was defined when low muscle mass plus low muscle strength or low physical performance were met. We used generalized estimating equations to examine the associations of sarcopenia. In the fully adjusted models, sarcopenia was significantly associated with lower cognitive function (standardized, β = −0.15; 95% CIs: −0.26, −0.04) and a higher BDRM score (standardized, β = 0.42; 95% CIs: 0.29, 0.55). Our findings may provide a new avenue for alleviating the burden of cognitive disorders by preventing sarcopenia.
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spelling pubmed-99654672023-02-26 Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study Lin, Ailing Wang, Ting Li, Chenxi Pu, Fan Abdelrahman, Zeinab Jin, Mengqi Yang, Zhenqing Zhang, Liming Cao, Xingqi Sun, Kaili Hou, Tongyao Liu, Zuyun Chen, Liying Chen, Zuobing Metabolites Article The relationship between skeletal muscle and cognitive disorders has drawn increasing attention. This study aims to examine the associations of sarcopenia with cognitive function and dementia risk score. Data on 1978 participants (aged 65 years and older) from the 2011 wave of the China Health and Retirement Longitudinal Study, with four follow-up waves to 2018, were used. Cognitive function was assessed by four dimensions, with a lower score indicating lower cognitive function. Dementia risk was assessed by a risk score using the Rotterdam Study Basic Dementia Risk Model (BDRM), with a higher score indicating a greater risk. Sarcopenia was defined when low muscle mass plus low muscle strength or low physical performance were met. We used generalized estimating equations to examine the associations of sarcopenia. In the fully adjusted models, sarcopenia was significantly associated with lower cognitive function (standardized, β = −0.15; 95% CIs: −0.26, −0.04) and a higher BDRM score (standardized, β = 0.42; 95% CIs: 0.29, 0.55). Our findings may provide a new avenue for alleviating the burden of cognitive disorders by preventing sarcopenia. MDPI 2023-02-08 /pmc/articles/PMC9965467/ /pubmed/36837864 http://dx.doi.org/10.3390/metabo13020245 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lin, Ailing
Wang, Ting
Li, Chenxi
Pu, Fan
Abdelrahman, Zeinab
Jin, Mengqi
Yang, Zhenqing
Zhang, Liming
Cao, Xingqi
Sun, Kaili
Hou, Tongyao
Liu, Zuyun
Chen, Liying
Chen, Zuobing
Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study
title Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study
title_full Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study
title_fullStr Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study
title_full_unstemmed Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study
title_short Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study
title_sort association of sarcopenia with cognitive function and dementia risk score: a national prospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965467/
https://www.ncbi.nlm.nih.gov/pubmed/36837864
http://dx.doi.org/10.3390/metabo13020245
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