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Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases

Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease i...

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Autores principales: Semyachkina-Glushkovskaya, Oxana, Fedosov, Ivan, Penzel, Thomas, Li, Dongyu, Yu, Tingting, Telnova, Valeria, Kaybeleva, Elmira, Saranceva, Elena, Terskov, Andrey, Khorovodov, Alexander, Blokhina, Inna, Kurths, Jürgen, Zhu, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965491/
https://www.ncbi.nlm.nih.gov/pubmed/36834631
http://dx.doi.org/10.3390/ijms24043221
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author Semyachkina-Glushkovskaya, Oxana
Fedosov, Ivan
Penzel, Thomas
Li, Dongyu
Yu, Tingting
Telnova, Valeria
Kaybeleva, Elmira
Saranceva, Elena
Terskov, Andrey
Khorovodov, Alexander
Blokhina, Inna
Kurths, Jürgen
Zhu, Dan
author_facet Semyachkina-Glushkovskaya, Oxana
Fedosov, Ivan
Penzel, Thomas
Li, Dongyu
Yu, Tingting
Telnova, Valeria
Kaybeleva, Elmira
Saranceva, Elena
Terskov, Andrey
Khorovodov, Alexander
Blokhina, Inna
Kurths, Jürgen
Zhu, Dan
author_sort Semyachkina-Glushkovskaya, Oxana
collection PubMed
description Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease in MLV function is associated with Alzheimer’s and Parkinson’s diseases, intracranial hemorrhages, brain tumors and trauma. Since the BWRS is activated during sleep, a new idea is now being actively discussed in the scientific community: night stimulation of the BWRS might be an innovative and promising strategy for neurorehabilitation medicine. This review highlights new trends in photobiomodulation of the BWRS/MLVs during deep sleep as a breakthrough technology for the effective removal of wastes and unnecessary compounds from the brain in order to increase the neuroprotection of the CNS as well as to prevent or delay various brain diseases.
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spelling pubmed-99654912023-02-26 Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases Semyachkina-Glushkovskaya, Oxana Fedosov, Ivan Penzel, Thomas Li, Dongyu Yu, Tingting Telnova, Valeria Kaybeleva, Elmira Saranceva, Elena Terskov, Andrey Khorovodov, Alexander Blokhina, Inna Kurths, Jürgen Zhu, Dan Int J Mol Sci Review Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease in MLV function is associated with Alzheimer’s and Parkinson’s diseases, intracranial hemorrhages, brain tumors and trauma. Since the BWRS is activated during sleep, a new idea is now being actively discussed in the scientific community: night stimulation of the BWRS might be an innovative and promising strategy for neurorehabilitation medicine. This review highlights new trends in photobiomodulation of the BWRS/MLVs during deep sleep as a breakthrough technology for the effective removal of wastes and unnecessary compounds from the brain in order to increase the neuroprotection of the CNS as well as to prevent or delay various brain diseases. MDPI 2023-02-06 /pmc/articles/PMC9965491/ /pubmed/36834631 http://dx.doi.org/10.3390/ijms24043221 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Semyachkina-Glushkovskaya, Oxana
Fedosov, Ivan
Penzel, Thomas
Li, Dongyu
Yu, Tingting
Telnova, Valeria
Kaybeleva, Elmira
Saranceva, Elena
Terskov, Andrey
Khorovodov, Alexander
Blokhina, Inna
Kurths, Jürgen
Zhu, Dan
Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases
title Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases
title_full Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases
title_fullStr Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases
title_full_unstemmed Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases
title_short Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases
title_sort brain waste removal system and sleep: photobiomodulation as an innovative strategy for night therapy of brain diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965491/
https://www.ncbi.nlm.nih.gov/pubmed/36834631
http://dx.doi.org/10.3390/ijms24043221
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