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Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases
Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease i...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965491/ https://www.ncbi.nlm.nih.gov/pubmed/36834631 http://dx.doi.org/10.3390/ijms24043221 |
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author | Semyachkina-Glushkovskaya, Oxana Fedosov, Ivan Penzel, Thomas Li, Dongyu Yu, Tingting Telnova, Valeria Kaybeleva, Elmira Saranceva, Elena Terskov, Andrey Khorovodov, Alexander Blokhina, Inna Kurths, Jürgen Zhu, Dan |
author_facet | Semyachkina-Glushkovskaya, Oxana Fedosov, Ivan Penzel, Thomas Li, Dongyu Yu, Tingting Telnova, Valeria Kaybeleva, Elmira Saranceva, Elena Terskov, Andrey Khorovodov, Alexander Blokhina, Inna Kurths, Jürgen Zhu, Dan |
author_sort | Semyachkina-Glushkovskaya, Oxana |
collection | PubMed |
description | Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease in MLV function is associated with Alzheimer’s and Parkinson’s diseases, intracranial hemorrhages, brain tumors and trauma. Since the BWRS is activated during sleep, a new idea is now being actively discussed in the scientific community: night stimulation of the BWRS might be an innovative and promising strategy for neurorehabilitation medicine. This review highlights new trends in photobiomodulation of the BWRS/MLVs during deep sleep as a breakthrough technology for the effective removal of wastes and unnecessary compounds from the brain in order to increase the neuroprotection of the CNS as well as to prevent or delay various brain diseases. |
format | Online Article Text |
id | pubmed-9965491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99654912023-02-26 Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases Semyachkina-Glushkovskaya, Oxana Fedosov, Ivan Penzel, Thomas Li, Dongyu Yu, Tingting Telnova, Valeria Kaybeleva, Elmira Saranceva, Elena Terskov, Andrey Khorovodov, Alexander Blokhina, Inna Kurths, Jürgen Zhu, Dan Int J Mol Sci Review Emerging evidence suggests that an important function of the sleeping brain is the removal of wastes and toxins from the central nervous system (CNS) due to the activation of the brain waste removal system (BWRS). The meningeal lymphatic vessels (MLVs) are an important part of the BWRS. A decrease in MLV function is associated with Alzheimer’s and Parkinson’s diseases, intracranial hemorrhages, brain tumors and trauma. Since the BWRS is activated during sleep, a new idea is now being actively discussed in the scientific community: night stimulation of the BWRS might be an innovative and promising strategy for neurorehabilitation medicine. This review highlights new trends in photobiomodulation of the BWRS/MLVs during deep sleep as a breakthrough technology for the effective removal of wastes and unnecessary compounds from the brain in order to increase the neuroprotection of the CNS as well as to prevent or delay various brain diseases. MDPI 2023-02-06 /pmc/articles/PMC9965491/ /pubmed/36834631 http://dx.doi.org/10.3390/ijms24043221 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Semyachkina-Glushkovskaya, Oxana Fedosov, Ivan Penzel, Thomas Li, Dongyu Yu, Tingting Telnova, Valeria Kaybeleva, Elmira Saranceva, Elena Terskov, Andrey Khorovodov, Alexander Blokhina, Inna Kurths, Jürgen Zhu, Dan Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases |
title | Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases |
title_full | Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases |
title_fullStr | Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases |
title_full_unstemmed | Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases |
title_short | Brain Waste Removal System and Sleep: Photobiomodulation as an Innovative Strategy for Night Therapy of Brain Diseases |
title_sort | brain waste removal system and sleep: photobiomodulation as an innovative strategy for night therapy of brain diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965491/ https://www.ncbi.nlm.nih.gov/pubmed/36834631 http://dx.doi.org/10.3390/ijms24043221 |
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