Cargando…

High-Energy, Whole-Body Proton Irradiation Differentially Alters Long-Term Brain Pathology and Behavior Dependent on Sex and Alzheimer’s Disease Mutations

Whole-body exposure to high-energy particle radiation remains an unmitigated hazard to human health in space. Ongoing experiments at the NASA Space Radiation Laboratory and elsewhere repeatedly show persistent changes in brain function long after exposure to simulations of this unique radiation envi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hinshaw, Robert G., Schroeder, Maren K., Ciola, Jason, Varma, Curran, Colletti, Brianna, Liu, Bin, Liu, Grace Geyu, Shi, Qiaoqiao, Williams, Jacqueline P., O’Banion, M. Kerry, Caldarone, Barbara J., Lemere, Cynthia A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965515/ https://www.ncbi.nlm.nih.gov/pubmed/36835027 http://dx.doi.org/10.3390/ijms24043615

Ejemplares similares

Long-Term Sex- and Genotype-Specific Effects of (56)Fe Irradiation on Wild-Type and APPswe/PS1dE9 Transgenic Mice
por: Schroeder, Maren K., et al.
Publicado: (2021)

Space-like (56)Fe irradiation manifests mild, early sex-specific behavioral and neuropathological changes in wildtype and Alzheimer’s-like transgenic mice
por: Liu, Bin, et al.
Publicado: (2019)

Galactic Cosmic Radiation Leads to Cognitive Impairment and Increased Aβ Plaque Accumulation in a Mouse Model of Alzheimer’s Disease
por: Cherry, Jonathan D., et al.
Publicado: (2012)

Cranial irradiation mediated spine loss is sex-specific and complement receptor-3 dependent in male mice
por: Hinkle, Joshua J., et al.
Publicado: (2019)

Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling
por: Moravan, Michael J., et al.
Publicado: (2016)

The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective
por: Shaftel, Solomon S, et al.
Publicado: (2008)

AAV gene therapy vectors in the TMJ
por: Brouxhon, Sabine M., et al.
Publicado: (2022)

Inconsistent Effects of Glatiramer Acetate Treatment in the 5xFAD Mouse Model of Alzheimer’s Disease
por: Karaahmet, Berke, et al.
Publicado: (2023)

Light-Controlled Release of Therapeutic Proteins from Red Blood Cells
por: Vickerman, Brianna M., et al.
Publicado: (2020)

Does an old dog need new tricks? Advancement of limb salvage in treating chronic limb threatening ischemia
por: O'Banion, Leigh Ann
Publicado: (2023)

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed
por: Cherry, Jonathan D, et al.
Publicado: (2014)

Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation
por: Cherry, Jonathan D., et al.
Publicado: (2015)

Are “Resting” Microglia More “M2”?
por: Cherry, Jonathan D., et al.
Publicado: (2014)

Cranial irradiation acutely and persistently impairs injury-induced microglial proliferation
por: Belcher, Elizabeth K., et al.
Publicado: (2020)

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease
por: Dionisio-Santos, Dawling A., et al.
Publicado: (2019)

Calcitonin gene‐related peptide: An intra‐articular therapeutic target for TMJ disorders
por: Brouxhon, Sabine M., et al.
Publicado: (2022)

Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer’s disease
por: Chockanathan, Udaysankar, et al.
Publicado: (2020)

Evaluating the Effect of Interleukin-4 in the 3xTg Mouse Model of Alzheimer’s Disease
por: Dionisio-Santos, Dawling A., et al.
Publicado: (2020)

Repopulated microglia induce expression of Cxcl13 with differential changes in Tau phosphorylation but do not impact amyloid pathology
por: Karaahmet, Berke, et al.
Publicado: (2022)

Coronavirus Disease 2019–Related Health Disparities in Ophthalmology with a Retrospective Analysis at a Large Academic Public Hospital
por: Chung, Y. Grace, et al.
Publicado: (2022)

Surgical management of a large mycotic aneurysm of the distal popliteal artery
por: McCullough, Kyle, et al.
Publicado: (2022)

Surgical management of carotid stump syndrome
por: Lucero, Leah, et al.
Publicado: (2023)

4274 Thirteen Years of Pipeline Programming at the University of Rochester’s Clinical & Translational Science Institute to Train Physician-Scientists
por: Maiorano, Alaina, et al.
Publicado: (2020)

Cognitively supernormal older adults maintain a unique structural connectome that is resistant to Alzheimer’s pathology
por: Chen, Quanjing, et al.
Publicado: (2020)

Exploring the pros and cons of using artificial intelligence in manuscript preparation for scientific journals
por: Smeds, Matthew R., et al.
Publicado: (2023)

Cardiac-Sparing and Breast-Sparing Whole Lung Irradiation Using Intensity-Modulated Proton Therapy
por: Wong, Ru Xin, et al.
Publicado: (2021)

Designed-seamless irradiation technique for extended whole mediastinal proton-beam irradiation for esophageal cancer
por: Okonogi, Noriyuki, et al.
Publicado: (2012)

Conditional expression of human β-hexosaminidase in the neurons of Sandhoff disease rescues mice from neurodegeneration but not neuroinflammation
por: Kyrkanides, Stephanos, et al.
Publicado: (2012)

A new year brings a new editorial board!
por: Smeds, Matthew R., et al.
Publicado: (2023)

Referral patterns for retinoblastoma patients in Ethiopia
por: Sherief, Sadik Taju, et al.
Publicado: (2023)

Health Services Needs Assessment for Retinoblastoma in Ethiopia
por: Sherief, Sadik Taju, et al.
Publicado: (2023)

IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia
por: Rivera-Escalera, Fátima, et al.
Publicado: (2019)

Evaluating Effects of Glatiramer Acetate Treatment on Amyloid Deposition and Tau Phosphorylation in the 3xTg Mouse Model of Alzheimer’s Disease
por: Dionisio-Santos, Dawling A., et al.
Publicado: (2021)

Selective memory and behavioral alterations after ambient ultrafine particulate matter exposure in aged 3xTgAD Alzheimer’s disease mice
por: Jew, Katrina, et al.
Publicado: (2019)

Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer’s disease
por: Owlett, Laura D., et al.
Publicado: (2022)

Correction: Gas6 induces infammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer’s disease
por: Owlett, Laura D., et al.
Publicado: (2023)

Immunotherapy for Alzheimer’s disease: hoops and hurdles
por: Lemere, Cynthia A
Publicado: (2013)

Whole breast proton irradiation for maximal reduction of heart dose in breast cancer patients
por: Mast, Mirjam E., et al.
Publicado: (2014)

The impact of the COVID-19 pandemic on wellness among vascular surgeons
por: Drudi, Laura M., et al.
Publicado: (2021)

Cognitive and Imaging Differences After Proton and Photon Whole Brain Irradiation in a Preclinical Model
por: Tang, Tien T., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vsemf473r99fdc6id381doon83