Integrating In Vitro Biopharmaceutics into Physiologically Based Biopharmaceutic Model (PBBM) to Predict Food Effect of BCS IV Zwitterionic Drug (GSK3640254)

A strategy followed to integrate in vitro solubility and permeability data into a PBBM model to predict the food effect of a BCS IV zwitterionic drug (GSK3640254) observed in clinical studies is described. The PBBM model was developed, qualified and verified using clinical data of an immediate relea...

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Detalles Bibliográficos
Autores principales: Stamatopoulos, Konstantinos, Ferrini, Paola, Nguyen, Dung, Zhang, Ying, Butler, James M., Hall, Jon, Mistry, Nena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965536/
https://www.ncbi.nlm.nih.gov/pubmed/36839843
http://dx.doi.org/10.3390/pharmaceutics15020521

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