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The Ketogenic Diet in Colorectal Cancer: A Means to an End
Some diets, such as high lipid and high glucose diets, are known to increase the risk of colorectal cancer. On the other hand, little is known about diets that prevent colonic carcinogenesis. The ketogenic diet, which is characterized by high fat and very low carbohydrate content, is one such diet....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965563/ https://www.ncbi.nlm.nih.gov/pubmed/36835094 http://dx.doi.org/10.3390/ijms24043683 |
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author | Tamraz, Magie Al Ghossaini, Najib Temraz, Sally |
author_facet | Tamraz, Magie Al Ghossaini, Najib Temraz, Sally |
author_sort | Tamraz, Magie |
collection | PubMed |
description | Some diets, such as high lipid and high glucose diets, are known to increase the risk of colorectal cancer. On the other hand, little is known about diets that prevent colonic carcinogenesis. The ketogenic diet, which is characterized by high fat and very low carbohydrate content, is one such diet. The ketogenic diet decreases the amount of available glucose for tumors and shifts to the production of ketone bodies as an alternative energy source for healthy cells. Cancer cells are unable to use the ketone bodies for energy thus depriving them of the energy needed for progression and survival. Many studies reported the beneficial effects of the ketogenic diet in several types of cancers. Recently, the ketone body β-hydroxybutyrate has been found to possess anti-tumor potential in colorectal cancer. Despite its beneficial effects, the ketogenic diet also has some drawbacks, some of which are related to gastrointestinal disorders and weight loss. Thus, studies are being directed at this time towards finding alternatives to following a strict ketogenic diet and supplementing patients with the ketone bodies responsible for its beneficial effects in the hope of overcoming some potential setbacks. This article discusses the mechanism by which a ketogenic diet influences growth and proliferation of tumor cells, it sheds the light on the most recent trials regarding its use as an adjunctive measure to chemotherapy in patients with metastatic colorectal cancer, and it explains the limitations of its usage in metastatic patients and the promising role of exogenous ketone supplementation in this setting. |
format | Online Article Text |
id | pubmed-9965563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99655632023-02-26 The Ketogenic Diet in Colorectal Cancer: A Means to an End Tamraz, Magie Al Ghossaini, Najib Temraz, Sally Int J Mol Sci Review Some diets, such as high lipid and high glucose diets, are known to increase the risk of colorectal cancer. On the other hand, little is known about diets that prevent colonic carcinogenesis. The ketogenic diet, which is characterized by high fat and very low carbohydrate content, is one such diet. The ketogenic diet decreases the amount of available glucose for tumors and shifts to the production of ketone bodies as an alternative energy source for healthy cells. Cancer cells are unable to use the ketone bodies for energy thus depriving them of the energy needed for progression and survival. Many studies reported the beneficial effects of the ketogenic diet in several types of cancers. Recently, the ketone body β-hydroxybutyrate has been found to possess anti-tumor potential in colorectal cancer. Despite its beneficial effects, the ketogenic diet also has some drawbacks, some of which are related to gastrointestinal disorders and weight loss. Thus, studies are being directed at this time towards finding alternatives to following a strict ketogenic diet and supplementing patients with the ketone bodies responsible for its beneficial effects in the hope of overcoming some potential setbacks. This article discusses the mechanism by which a ketogenic diet influences growth and proliferation of tumor cells, it sheds the light on the most recent trials regarding its use as an adjunctive measure to chemotherapy in patients with metastatic colorectal cancer, and it explains the limitations of its usage in metastatic patients and the promising role of exogenous ketone supplementation in this setting. MDPI 2023-02-12 /pmc/articles/PMC9965563/ /pubmed/36835094 http://dx.doi.org/10.3390/ijms24043683 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tamraz, Magie Al Ghossaini, Najib Temraz, Sally The Ketogenic Diet in Colorectal Cancer: A Means to an End |
title | The Ketogenic Diet in Colorectal Cancer: A Means to an End |
title_full | The Ketogenic Diet in Colorectal Cancer: A Means to an End |
title_fullStr | The Ketogenic Diet in Colorectal Cancer: A Means to an End |
title_full_unstemmed | The Ketogenic Diet in Colorectal Cancer: A Means to an End |
title_short | The Ketogenic Diet in Colorectal Cancer: A Means to an End |
title_sort | ketogenic diet in colorectal cancer: a means to an end |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965563/ https://www.ncbi.nlm.nih.gov/pubmed/36835094 http://dx.doi.org/10.3390/ijms24043683 |
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