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Liver Damage Associated with SARS-CoV-2 Infection—Myth or Reality?

(1) Introduction: While the primary impairment in COVID-19 is pulmonary, the ubiquitous distribution of angiotensin-converting enzyme 2 (ACE2) demonstrates the possible presence of systemic disease with involvement of the heart, kidneys, liver and other organs. (2) Methods: We retrospectively studie...

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Autores principales: Luca, Mihaela Cătălina, Loghin, Isabela Ioana, Mihai, Ioana Florina, Popa, Radu, Vâţă, Andrei, Manciuc, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965594/
https://www.ncbi.nlm.nih.gov/pubmed/36836583
http://dx.doi.org/10.3390/jpm13020349
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author Luca, Mihaela Cătălina
Loghin, Isabela Ioana
Mihai, Ioana Florina
Popa, Radu
Vâţă, Andrei
Manciuc, Carmen
author_facet Luca, Mihaela Cătălina
Loghin, Isabela Ioana
Mihai, Ioana Florina
Popa, Radu
Vâţă, Andrei
Manciuc, Carmen
author_sort Luca, Mihaela Cătălina
collection PubMed
description (1) Introduction: While the primary impairment in COVID-19 is pulmonary, the ubiquitous distribution of angiotensin-converting enzyme 2 (ACE2) demonstrates the possible presence of systemic disease with involvement of the heart, kidneys, liver and other organs. (2) Methods: We retrospectively studied the observation sheets of patients diagnosed with SARS-CoV-2 infection hospitalized in the “Sf. Parascheva” Clinical Hospital of Infectious Diseases from Iasi for a period of 3 months. The aim of the study was to identify the frequency of liver injury due to SARS-CoV-2 infection among patients and its impact on the course of the disease. (3) Results: Out of the total number of hospitalized cases (1552), 207 (13.34%) were the subjects of our analysis. The severe form of SARS-CoV-2 infection predominated (108 cases; 52.17%) and in terms of liver damage, in all cases increased transaminase levels predominated and were determined to be secondary to the viral infection. We divided the lot into two groups, A (23 cases; 23.19%) and B (159 cases; 76.81%), depending on the time of onset of liver dysfunction, either at the time of hospitalization or during hospitalization. The evolution of liver dysfunction was predominant in most cases, with an average time of onset at 12.4 days of hospitalization. Death occurred in 50 cases. (4) Conclusions: This study revealed that high AST and ALT at hospital admission was associated with a high mortality risk in COVID-19 patients. Therefore, abnormal liver test results can be a significant prognostic indicator of outcomes in COVID-19 patients.
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spelling pubmed-99655942023-02-26 Liver Damage Associated with SARS-CoV-2 Infection—Myth or Reality? Luca, Mihaela Cătălina Loghin, Isabela Ioana Mihai, Ioana Florina Popa, Radu Vâţă, Andrei Manciuc, Carmen J Pers Med Article (1) Introduction: While the primary impairment in COVID-19 is pulmonary, the ubiquitous distribution of angiotensin-converting enzyme 2 (ACE2) demonstrates the possible presence of systemic disease with involvement of the heart, kidneys, liver and other organs. (2) Methods: We retrospectively studied the observation sheets of patients diagnosed with SARS-CoV-2 infection hospitalized in the “Sf. Parascheva” Clinical Hospital of Infectious Diseases from Iasi for a period of 3 months. The aim of the study was to identify the frequency of liver injury due to SARS-CoV-2 infection among patients and its impact on the course of the disease. (3) Results: Out of the total number of hospitalized cases (1552), 207 (13.34%) were the subjects of our analysis. The severe form of SARS-CoV-2 infection predominated (108 cases; 52.17%) and in terms of liver damage, in all cases increased transaminase levels predominated and were determined to be secondary to the viral infection. We divided the lot into two groups, A (23 cases; 23.19%) and B (159 cases; 76.81%), depending on the time of onset of liver dysfunction, either at the time of hospitalization or during hospitalization. The evolution of liver dysfunction was predominant in most cases, with an average time of onset at 12.4 days of hospitalization. Death occurred in 50 cases. (4) Conclusions: This study revealed that high AST and ALT at hospital admission was associated with a high mortality risk in COVID-19 patients. Therefore, abnormal liver test results can be a significant prognostic indicator of outcomes in COVID-19 patients. MDPI 2023-02-17 /pmc/articles/PMC9965594/ /pubmed/36836583 http://dx.doi.org/10.3390/jpm13020349 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Luca, Mihaela Cătălina
Loghin, Isabela Ioana
Mihai, Ioana Florina
Popa, Radu
Vâţă, Andrei
Manciuc, Carmen
Liver Damage Associated with SARS-CoV-2 Infection—Myth or Reality?
title Liver Damage Associated with SARS-CoV-2 Infection—Myth or Reality?
title_full Liver Damage Associated with SARS-CoV-2 Infection—Myth or Reality?
title_fullStr Liver Damage Associated with SARS-CoV-2 Infection—Myth or Reality?
title_full_unstemmed Liver Damage Associated with SARS-CoV-2 Infection—Myth or Reality?
title_short Liver Damage Associated with SARS-CoV-2 Infection—Myth or Reality?
title_sort liver damage associated with sars-cov-2 infection—myth or reality?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965594/
https://www.ncbi.nlm.nih.gov/pubmed/36836583
http://dx.doi.org/10.3390/jpm13020349
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