Targeting Glutaminolysis Shows Efficacy in Both Prednisolone-Sensitive and in Metabolically Rewired Prednisolone-Resistant B-Cell Childhood Acute Lymphoblastic Leukaemia Cells

The prognosis for patients with relapsed childhood acute lymphoblastic leukaemia (cALL) remains poor. The main reason for treatment failure is drug resistance, most commonly to glucocorticoids (GCs). The molecular differences between prednisolone-sensitive and -resistant lymphoblasts are not well-st...

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Detalles Bibliográficos
Autores principales: Sbirkov, Yordan, Vergov, Bozhidar, Dzharov, Vasil, Schenk, Tino, Petrie, Kevin, Sarafian, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965631/
https://www.ncbi.nlm.nih.gov/pubmed/36834787
http://dx.doi.org/10.3390/ijms24043378

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965631/
https://www.ncbi.nlm.nih.gov/pubmed/36834787
http://dx.doi.org/10.3390/ijms24043378

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