Cargando…
Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases
Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) resulting from an immune-mediated response in susceptible and sensitized individuals to a large variety of inhaled antigens. Chronic HP with a fibrotic phenotype is characterized by disease progression and a dismal prognosis. Th...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965638/ https://www.ncbi.nlm.nih.gov/pubmed/36836825 http://dx.doi.org/10.3390/life13020467 |
_version_ | 1784896814967685120 |
---|---|
author | Trushenko, Natalia V. Suvorova, Olga A. Pershina, Ekaterina S. Nekludova, Galina V. Chikina, Svetlana Yu. Levina, Iuliia A. Chernyaev, Andrey L. Samsonova, Maria V. Tyurin, Igor E. Mustafina, Malika Kh. Yaroshetskiy, Andrey I. Nadtochiy, Nikita B. Merzhoeva, Zamira M. Proshkina, Anna A. Avdeev, Sergey N. |
author_facet | Trushenko, Natalia V. Suvorova, Olga A. Pershina, Ekaterina S. Nekludova, Galina V. Chikina, Svetlana Yu. Levina, Iuliia A. Chernyaev, Andrey L. Samsonova, Maria V. Tyurin, Igor E. Mustafina, Malika Kh. Yaroshetskiy, Andrey I. Nadtochiy, Nikita B. Merzhoeva, Zamira M. Proshkina, Anna A. Avdeev, Sergey N. |
author_sort | Trushenko, Natalia V. |
collection | PubMed |
description | Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) resulting from an immune-mediated response in susceptible and sensitized individuals to a large variety of inhaled antigens. Chronic HP with a fibrotic phenotype is characterized by disease progression and a dismal prognosis. The aim of this study was to identify predictors of progression and mortality in patients with chronic HP in real clinical practice. Materials and methods: This retrospective, multicenter, observational study used data from a registry of 1355 patients with fibrosing ILDs. The study included 292 patients diagnosed with chronic HP based on the conclusion of a multidisciplinary discussion (MDD). Results: The patients were divided into groups with progressive (92 (30.3%) patients) and nonprogressive pulmonary fibrosis (200 (69.7%) patients). The most significant predictors of adverse outcomes were a DLco < 50% predicted, an SpO2 at the end of a six-minute walk test (6-MWT) < 85%, and a GAP score ≥ 4 points. Conclusion: Pulmonary fibrosis and a progressive fibrotic phenotype are common in patients with chronic HP. Early detection of the predictors of an adverse prognosis of chronic HP is necessary for the timely initiation of antifibrotic therapy. |
format | Online Article Text |
id | pubmed-9965638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99656382023-02-26 Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases Trushenko, Natalia V. Suvorova, Olga A. Pershina, Ekaterina S. Nekludova, Galina V. Chikina, Svetlana Yu. Levina, Iuliia A. Chernyaev, Andrey L. Samsonova, Maria V. Tyurin, Igor E. Mustafina, Malika Kh. Yaroshetskiy, Andrey I. Nadtochiy, Nikita B. Merzhoeva, Zamira M. Proshkina, Anna A. Avdeev, Sergey N. Life (Basel) Article Hypersensitivity pneumonitis (HP) is an interstitial lung disease (ILD) resulting from an immune-mediated response in susceptible and sensitized individuals to a large variety of inhaled antigens. Chronic HP with a fibrotic phenotype is characterized by disease progression and a dismal prognosis. The aim of this study was to identify predictors of progression and mortality in patients with chronic HP in real clinical practice. Materials and methods: This retrospective, multicenter, observational study used data from a registry of 1355 patients with fibrosing ILDs. The study included 292 patients diagnosed with chronic HP based on the conclusion of a multidisciplinary discussion (MDD). Results: The patients were divided into groups with progressive (92 (30.3%) patients) and nonprogressive pulmonary fibrosis (200 (69.7%) patients). The most significant predictors of adverse outcomes were a DLco < 50% predicted, an SpO2 at the end of a six-minute walk test (6-MWT) < 85%, and a GAP score ≥ 4 points. Conclusion: Pulmonary fibrosis and a progressive fibrotic phenotype are common in patients with chronic HP. Early detection of the predictors of an adverse prognosis of chronic HP is necessary for the timely initiation of antifibrotic therapy. MDPI 2023-02-08 /pmc/articles/PMC9965638/ /pubmed/36836825 http://dx.doi.org/10.3390/life13020467 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Trushenko, Natalia V. Suvorova, Olga A. Pershina, Ekaterina S. Nekludova, Galina V. Chikina, Svetlana Yu. Levina, Iuliia A. Chernyaev, Andrey L. Samsonova, Maria V. Tyurin, Igor E. Mustafina, Malika Kh. Yaroshetskiy, Andrey I. Nadtochiy, Nikita B. Merzhoeva, Zamira M. Proshkina, Anna A. Avdeev, Sergey N. Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases |
title | Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases |
title_full | Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases |
title_fullStr | Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases |
title_full_unstemmed | Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases |
title_short | Predictors of Progression and Mortality in Patients with Chronic Hypersensitivity Pneumonitis: Retrospective Analysis of Registry of Fibrosing Interstitial Lung Diseases |
title_sort | predictors of progression and mortality in patients with chronic hypersensitivity pneumonitis: retrospective analysis of registry of fibrosing interstitial lung diseases |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965638/ https://www.ncbi.nlm.nih.gov/pubmed/36836825 http://dx.doi.org/10.3390/life13020467 |
work_keys_str_mv | AT trushenkonataliav predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT suvorovaolgaa predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT pershinaekaterinas predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT nekludovagalinav predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT chikinasvetlanayu predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT levinaiuliiaa predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT chernyaevandreyl predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT samsonovamariav predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT tyurinigore predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT mustafinamalikakh predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT yaroshetskiyandreyi predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT nadtochiynikitab predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT merzhoevazamiram predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT proshkinaannaa predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases AT avdeevsergeyn predictorsofprogressionandmortalityinpatientswithchronichypersensitivitypneumonitisretrospectiveanalysisofregistryoffibrosinginterstitiallungdiseases |