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Mild Hyperbaric Oxygen Exposure Enhances Peripheral Circulatory Natural Killer Cells in Healthy Young Women

Mild hyperbaric oxygen (HBO) enhances oxygen absorption in blood, relieving fatigue without causing oxidative stress. The benefits of mild HBO have been recognized in the treatment of lifestyle-related diseases and hypertension, but no research has been conducted on its effects on immunity. The aim...

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Autores principales: Nisa, Badur Un, Nakanishi, Ryosuke, Tanaka, Minoru, Lin, Hao, Hirabayashi, Takumi, Maeshige, Noriaki, Kondo, Hiroyo, Fujino, Hidemi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965672/
https://www.ncbi.nlm.nih.gov/pubmed/36836764
http://dx.doi.org/10.3390/life13020408
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author Nisa, Badur Un
Nakanishi, Ryosuke
Tanaka, Minoru
Lin, Hao
Hirabayashi, Takumi
Maeshige, Noriaki
Kondo, Hiroyo
Fujino, Hidemi
author_facet Nisa, Badur Un
Nakanishi, Ryosuke
Tanaka, Minoru
Lin, Hao
Hirabayashi, Takumi
Maeshige, Noriaki
Kondo, Hiroyo
Fujino, Hidemi
author_sort Nisa, Badur Un
collection PubMed
description Mild hyperbaric oxygen (HBO) enhances oxygen absorption in blood, relieving fatigue without causing oxidative stress. The benefits of mild HBO have been recognized in the treatment of lifestyle-related diseases and hypertension, but no research has been conducted on its effects on immunity. The aim of the present study is to investigate the effect of mild HBO on natural killer (NK) cells and cytokines in healthy young women. This crossover randomized control trial was conducted with 16 healthy young women. Participants were randomly exposed to normobaric oxygen (NBO; 1.0 atmospheres absolute (ATA), 20.8% oxygen) and mild HBO conditions (1.4 ATA, 35–40% oxygen, injected 18L oxygen per minute) in a hyperbaric oxygen chamber for 70 min. Heart rate, parasympathetic activity, NK cell count, interleukin (IL)-6, IL-12p70 and derivatives of reactive oxygen metabolites (d-ROMs) were measured before and after both exposures. In the NBO condition, parasympathetic activity remained unchanged, whereas after mild HBO exposure, parasympathetic activity was significantly increased. NK cells remained unchanged after NBO exposure, while NK cells were increased after exposure to mild HBO. Exposure to mild HBO did not increase d-ROM values, IL-6 and IL-12p70 protein levels. These findings suggest that exposure to mild HBO can be a useful protocol to increase NK cells by regulating parasympathetic activity via increasing oxygen delivery.
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spelling pubmed-99656722023-02-26 Mild Hyperbaric Oxygen Exposure Enhances Peripheral Circulatory Natural Killer Cells in Healthy Young Women Nisa, Badur Un Nakanishi, Ryosuke Tanaka, Minoru Lin, Hao Hirabayashi, Takumi Maeshige, Noriaki Kondo, Hiroyo Fujino, Hidemi Life (Basel) Article Mild hyperbaric oxygen (HBO) enhances oxygen absorption in blood, relieving fatigue without causing oxidative stress. The benefits of mild HBO have been recognized in the treatment of lifestyle-related diseases and hypertension, but no research has been conducted on its effects on immunity. The aim of the present study is to investigate the effect of mild HBO on natural killer (NK) cells and cytokines in healthy young women. This crossover randomized control trial was conducted with 16 healthy young women. Participants were randomly exposed to normobaric oxygen (NBO; 1.0 atmospheres absolute (ATA), 20.8% oxygen) and mild HBO conditions (1.4 ATA, 35–40% oxygen, injected 18L oxygen per minute) in a hyperbaric oxygen chamber for 70 min. Heart rate, parasympathetic activity, NK cell count, interleukin (IL)-6, IL-12p70 and derivatives of reactive oxygen metabolites (d-ROMs) were measured before and after both exposures. In the NBO condition, parasympathetic activity remained unchanged, whereas after mild HBO exposure, parasympathetic activity was significantly increased. NK cells remained unchanged after NBO exposure, while NK cells were increased after exposure to mild HBO. Exposure to mild HBO did not increase d-ROM values, IL-6 and IL-12p70 protein levels. These findings suggest that exposure to mild HBO can be a useful protocol to increase NK cells by regulating parasympathetic activity via increasing oxygen delivery. MDPI 2023-02-01 /pmc/articles/PMC9965672/ /pubmed/36836764 http://dx.doi.org/10.3390/life13020408 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nisa, Badur Un
Nakanishi, Ryosuke
Tanaka, Minoru
Lin, Hao
Hirabayashi, Takumi
Maeshige, Noriaki
Kondo, Hiroyo
Fujino, Hidemi
Mild Hyperbaric Oxygen Exposure Enhances Peripheral Circulatory Natural Killer Cells in Healthy Young Women
title Mild Hyperbaric Oxygen Exposure Enhances Peripheral Circulatory Natural Killer Cells in Healthy Young Women
title_full Mild Hyperbaric Oxygen Exposure Enhances Peripheral Circulatory Natural Killer Cells in Healthy Young Women
title_fullStr Mild Hyperbaric Oxygen Exposure Enhances Peripheral Circulatory Natural Killer Cells in Healthy Young Women
title_full_unstemmed Mild Hyperbaric Oxygen Exposure Enhances Peripheral Circulatory Natural Killer Cells in Healthy Young Women
title_short Mild Hyperbaric Oxygen Exposure Enhances Peripheral Circulatory Natural Killer Cells in Healthy Young Women
title_sort mild hyperbaric oxygen exposure enhances peripheral circulatory natural killer cells in healthy young women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965672/
https://www.ncbi.nlm.nih.gov/pubmed/36836764
http://dx.doi.org/10.3390/life13020408
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