Cargando…

The First Nationwide Surveillance of Severe Fever with Thrombocytopenia Syndrome in Ruminants and Wildlife in Taiwan

Since the first discovery of severe fever with thrombocytopenia syndrome virus (SFTSV) in China in 2009, SFTSV has rapidly spread through other Asian countries, including Japan, Korea, Vietnam and Pakistan, in chronological order. Taiwan reported its first discovery of SFTSV in sheep and humans in 2...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuan, Chih-Ying, Lin, Tsai-Lu, Ou, Shan-Chia, Chuang, Shih-Te, Chan, Jacky Peng-Wen, Maeda, Ken, Mizutani, Tetsuya, Wu, Ming-Pin, Lee, Fan, Chan, Fang-Tse, Chang, Chao-Chin, Liang, Rui-Ling, Yang, Sue-Fung, Liu, Tsung-Ching, Tu, Wu-Chun, Tzeng, Hau-You, Lee, Chia-Jung, Lin, Chuen-Fu, Lee, Hsu-Hsun, Wu, Jhih-Hua, Lo, Hsiao-Chien, Tseng, Kuan-Chieh, Hsu, Wei-Li, Chou, Chi-Chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965706/
https://www.ncbi.nlm.nih.gov/pubmed/36851653
http://dx.doi.org/10.3390/v15020441
_version_ 1784896831743852544
author Kuan, Chih-Ying
Lin, Tsai-Lu
Ou, Shan-Chia
Chuang, Shih-Te
Chan, Jacky Peng-Wen
Maeda, Ken
Mizutani, Tetsuya
Wu, Ming-Pin
Lee, Fan
Chan, Fang-Tse
Chang, Chao-Chin
Liang, Rui-Ling
Yang, Sue-Fung
Liu, Tsung-Ching
Tu, Wu-Chun
Tzeng, Hau-You
Lee, Chia-Jung
Lin, Chuen-Fu
Lee, Hsu-Hsun
Wu, Jhih-Hua
Lo, Hsiao-Chien
Tseng, Kuan-Chieh
Hsu, Wei-Li
Chou, Chi-Chung
author_facet Kuan, Chih-Ying
Lin, Tsai-Lu
Ou, Shan-Chia
Chuang, Shih-Te
Chan, Jacky Peng-Wen
Maeda, Ken
Mizutani, Tetsuya
Wu, Ming-Pin
Lee, Fan
Chan, Fang-Tse
Chang, Chao-Chin
Liang, Rui-Ling
Yang, Sue-Fung
Liu, Tsung-Ching
Tu, Wu-Chun
Tzeng, Hau-You
Lee, Chia-Jung
Lin, Chuen-Fu
Lee, Hsu-Hsun
Wu, Jhih-Hua
Lo, Hsiao-Chien
Tseng, Kuan-Chieh
Hsu, Wei-Li
Chou, Chi-Chung
author_sort Kuan, Chih-Ying
collection PubMed
description Since the first discovery of severe fever with thrombocytopenia syndrome virus (SFTSV) in China in 2009, SFTSV has rapidly spread through other Asian countries, including Japan, Korea, Vietnam and Pakistan, in chronological order. Taiwan reported its first discovery of SFTSV in sheep and humans in 2020. However, the prevalence of SFTSV in domestic and wildlife animals and the geographic distribution of the virus within the island remain unknown. A total of 1324 animal samples, including 803 domestic ruminants, 521 wildlife animals and 47 tick pools, were collected from March 2021 to December 2022 from 12 counties and one terrestrial island. The viral RNA was detected by a one-step real-time reverse transcription polymerase chain reaction (RT-PCR). Overall, 29.9% (240/803) of ruminants showed positive SFTSV RNA. Sheep had the highest viral RNA prevalence of 60% (30/50), followed by beef cattle at 28.4% (44/155), goats at 28.3% (47/166), and dairy cows at 27.5% (119/432). The bovine as a total of dairy cow and beef cattle was 27.8% (163/587). The viral RNA prevalence in ticks (predominantly Rhipicephalus microplus) was similar to those of ruminants at 27.7% (13/47), but wild animals exhibited a much lower prevalence at 1.3% (7/521). Geographically the distribution of positivity was quite even, being 33%, 29.1%, 27.5% and 37.5% for northern, central, southern and eastern Taiwan, respectively. Statistically, the positive rate of beef cattle in the central region (55.6%) and dairy cattle in the eastern region (40.6%) were significantly higher than the other regions; and the prevalence in Autumn (September–November) was significantly higher than in the other seasons (p < 0.001). The nationwide study herein revealed for the first time the wide distribution and high prevalence of SFTSV in both domestic animals and ticks in Taiwan. Considering the high mortality rate in humans, surveillance of other animal species, particularly those in close contact with humans, and instigation of protective measures for farmers, veterinarians, and especially older populations visiting or living near farms or rural areas should be prioritized.
format Online
Article
Text
id pubmed-9965706
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99657062023-02-26 The First Nationwide Surveillance of Severe Fever with Thrombocytopenia Syndrome in Ruminants and Wildlife in Taiwan Kuan, Chih-Ying Lin, Tsai-Lu Ou, Shan-Chia Chuang, Shih-Te Chan, Jacky Peng-Wen Maeda, Ken Mizutani, Tetsuya Wu, Ming-Pin Lee, Fan Chan, Fang-Tse Chang, Chao-Chin Liang, Rui-Ling Yang, Sue-Fung Liu, Tsung-Ching Tu, Wu-Chun Tzeng, Hau-You Lee, Chia-Jung Lin, Chuen-Fu Lee, Hsu-Hsun Wu, Jhih-Hua Lo, Hsiao-Chien Tseng, Kuan-Chieh Hsu, Wei-Li Chou, Chi-Chung Viruses Article Since the first discovery of severe fever with thrombocytopenia syndrome virus (SFTSV) in China in 2009, SFTSV has rapidly spread through other Asian countries, including Japan, Korea, Vietnam and Pakistan, in chronological order. Taiwan reported its first discovery of SFTSV in sheep and humans in 2020. However, the prevalence of SFTSV in domestic and wildlife animals and the geographic distribution of the virus within the island remain unknown. A total of 1324 animal samples, including 803 domestic ruminants, 521 wildlife animals and 47 tick pools, were collected from March 2021 to December 2022 from 12 counties and one terrestrial island. The viral RNA was detected by a one-step real-time reverse transcription polymerase chain reaction (RT-PCR). Overall, 29.9% (240/803) of ruminants showed positive SFTSV RNA. Sheep had the highest viral RNA prevalence of 60% (30/50), followed by beef cattle at 28.4% (44/155), goats at 28.3% (47/166), and dairy cows at 27.5% (119/432). The bovine as a total of dairy cow and beef cattle was 27.8% (163/587). The viral RNA prevalence in ticks (predominantly Rhipicephalus microplus) was similar to those of ruminants at 27.7% (13/47), but wild animals exhibited a much lower prevalence at 1.3% (7/521). Geographically the distribution of positivity was quite even, being 33%, 29.1%, 27.5% and 37.5% for northern, central, southern and eastern Taiwan, respectively. Statistically, the positive rate of beef cattle in the central region (55.6%) and dairy cattle in the eastern region (40.6%) were significantly higher than the other regions; and the prevalence in Autumn (September–November) was significantly higher than in the other seasons (p < 0.001). The nationwide study herein revealed for the first time the wide distribution and high prevalence of SFTSV in both domestic animals and ticks in Taiwan. Considering the high mortality rate in humans, surveillance of other animal species, particularly those in close contact with humans, and instigation of protective measures for farmers, veterinarians, and especially older populations visiting or living near farms or rural areas should be prioritized. MDPI 2023-02-05 /pmc/articles/PMC9965706/ /pubmed/36851653 http://dx.doi.org/10.3390/v15020441 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kuan, Chih-Ying
Lin, Tsai-Lu
Ou, Shan-Chia
Chuang, Shih-Te
Chan, Jacky Peng-Wen
Maeda, Ken
Mizutani, Tetsuya
Wu, Ming-Pin
Lee, Fan
Chan, Fang-Tse
Chang, Chao-Chin
Liang, Rui-Ling
Yang, Sue-Fung
Liu, Tsung-Ching
Tu, Wu-Chun
Tzeng, Hau-You
Lee, Chia-Jung
Lin, Chuen-Fu
Lee, Hsu-Hsun
Wu, Jhih-Hua
Lo, Hsiao-Chien
Tseng, Kuan-Chieh
Hsu, Wei-Li
Chou, Chi-Chung
The First Nationwide Surveillance of Severe Fever with Thrombocytopenia Syndrome in Ruminants and Wildlife in Taiwan
title The First Nationwide Surveillance of Severe Fever with Thrombocytopenia Syndrome in Ruminants and Wildlife in Taiwan
title_full The First Nationwide Surveillance of Severe Fever with Thrombocytopenia Syndrome in Ruminants and Wildlife in Taiwan
title_fullStr The First Nationwide Surveillance of Severe Fever with Thrombocytopenia Syndrome in Ruminants and Wildlife in Taiwan
title_full_unstemmed The First Nationwide Surveillance of Severe Fever with Thrombocytopenia Syndrome in Ruminants and Wildlife in Taiwan
title_short The First Nationwide Surveillance of Severe Fever with Thrombocytopenia Syndrome in Ruminants and Wildlife in Taiwan
title_sort first nationwide surveillance of severe fever with thrombocytopenia syndrome in ruminants and wildlife in taiwan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965706/
https://www.ncbi.nlm.nih.gov/pubmed/36851653
http://dx.doi.org/10.3390/v15020441
work_keys_str_mv AT kuanchihying thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT lintsailu thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT oushanchia thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT chuangshihte thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT chanjackypengwen thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT maedaken thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT mizutanitetsuya thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT wumingpin thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT leefan thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT chanfangtse thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT changchaochin thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT liangruiling thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT yangsuefung thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT liutsungching thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT tuwuchun thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT tzenghauyou thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT leechiajung thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT linchuenfu thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT leehsuhsun thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT wujhihhua thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT lohsiaochien thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT tsengkuanchieh thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT hsuweili thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT chouchichung thefirstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT kuanchihying firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT lintsailu firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT oushanchia firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT chuangshihte firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT chanjackypengwen firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT maedaken firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT mizutanitetsuya firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT wumingpin firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT leefan firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT chanfangtse firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT changchaochin firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT liangruiling firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT yangsuefung firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT liutsungching firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT tuwuchun firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT tzenghauyou firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT leechiajung firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT linchuenfu firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT leehsuhsun firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT wujhihhua firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT lohsiaochien firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT tsengkuanchieh firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT hsuweili firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan
AT chouchichung firstnationwidesurveillanceofseverefeverwiththrombocytopeniasyndromeinruminantsandwildlifeintaiwan