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Drug Discovery and Development Targeting Dementia
Dementia, most often associated with neurodegenerative diseases, affects millions of people worldwide, predominantly the elderly. Unfortunately, no treatment is still available. Therefore, there is an urgent need to address this situation. This review presents the state of the art of drug discovery...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965722/ https://www.ncbi.nlm.nih.gov/pubmed/37259302 http://dx.doi.org/10.3390/ph16020151 |
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author | Zagórska, Agnieszka Czopek, Anna Fryc, Monika Jaromin, Anna Boyd, Ben J. |
author_facet | Zagórska, Agnieszka Czopek, Anna Fryc, Monika Jaromin, Anna Boyd, Ben J. |
author_sort | Zagórska, Agnieszka |
collection | PubMed |
description | Dementia, most often associated with neurodegenerative diseases, affects millions of people worldwide, predominantly the elderly. Unfortunately, no treatment is still available. Therefore, there is an urgent need to address this situation. This review presents the state of the art of drug discovery and developments in targeting dementia. Several approaches are discussed, such as drug repurposing, the use of small molecules, and phosphodiesterase inhibitors. Furthermore, the review also provides insights into clinical trials of these molecules. Emphasis has been placed on small molecules and multi-target-directed ligands, as well as disease-modifying therapies. Finally, attention is drawn to the possibilities of applications of nanotechnology in managing dementia. |
format | Online Article Text |
id | pubmed-9965722 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99657222023-02-26 Drug Discovery and Development Targeting Dementia Zagórska, Agnieszka Czopek, Anna Fryc, Monika Jaromin, Anna Boyd, Ben J. Pharmaceuticals (Basel) Review Dementia, most often associated with neurodegenerative diseases, affects millions of people worldwide, predominantly the elderly. Unfortunately, no treatment is still available. Therefore, there is an urgent need to address this situation. This review presents the state of the art of drug discovery and developments in targeting dementia. Several approaches are discussed, such as drug repurposing, the use of small molecules, and phosphodiesterase inhibitors. Furthermore, the review also provides insights into clinical trials of these molecules. Emphasis has been placed on small molecules and multi-target-directed ligands, as well as disease-modifying therapies. Finally, attention is drawn to the possibilities of applications of nanotechnology in managing dementia. MDPI 2023-01-19 /pmc/articles/PMC9965722/ /pubmed/37259302 http://dx.doi.org/10.3390/ph16020151 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zagórska, Agnieszka Czopek, Anna Fryc, Monika Jaromin, Anna Boyd, Ben J. Drug Discovery and Development Targeting Dementia |
title | Drug Discovery and Development Targeting Dementia |
title_full | Drug Discovery and Development Targeting Dementia |
title_fullStr | Drug Discovery and Development Targeting Dementia |
title_full_unstemmed | Drug Discovery and Development Targeting Dementia |
title_short | Drug Discovery and Development Targeting Dementia |
title_sort | drug discovery and development targeting dementia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965722/ https://www.ncbi.nlm.nih.gov/pubmed/37259302 http://dx.doi.org/10.3390/ph16020151 |
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