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Drug Discovery and Development Targeting Dementia

Dementia, most often associated with neurodegenerative diseases, affects millions of people worldwide, predominantly the elderly. Unfortunately, no treatment is still available. Therefore, there is an urgent need to address this situation. This review presents the state of the art of drug discovery...

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Autores principales: Zagórska, Agnieszka, Czopek, Anna, Fryc, Monika, Jaromin, Anna, Boyd, Ben J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965722/
https://www.ncbi.nlm.nih.gov/pubmed/37259302
http://dx.doi.org/10.3390/ph16020151
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author Zagórska, Agnieszka
Czopek, Anna
Fryc, Monika
Jaromin, Anna
Boyd, Ben J.
author_facet Zagórska, Agnieszka
Czopek, Anna
Fryc, Monika
Jaromin, Anna
Boyd, Ben J.
author_sort Zagórska, Agnieszka
collection PubMed
description Dementia, most often associated with neurodegenerative diseases, affects millions of people worldwide, predominantly the elderly. Unfortunately, no treatment is still available. Therefore, there is an urgent need to address this situation. This review presents the state of the art of drug discovery and developments in targeting dementia. Several approaches are discussed, such as drug repurposing, the use of small molecules, and phosphodiesterase inhibitors. Furthermore, the review also provides insights into clinical trials of these molecules. Emphasis has been placed on small molecules and multi-target-directed ligands, as well as disease-modifying therapies. Finally, attention is drawn to the possibilities of applications of nanotechnology in managing dementia.
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spelling pubmed-99657222023-02-26 Drug Discovery and Development Targeting Dementia Zagórska, Agnieszka Czopek, Anna Fryc, Monika Jaromin, Anna Boyd, Ben J. Pharmaceuticals (Basel) Review Dementia, most often associated with neurodegenerative diseases, affects millions of people worldwide, predominantly the elderly. Unfortunately, no treatment is still available. Therefore, there is an urgent need to address this situation. This review presents the state of the art of drug discovery and developments in targeting dementia. Several approaches are discussed, such as drug repurposing, the use of small molecules, and phosphodiesterase inhibitors. Furthermore, the review also provides insights into clinical trials of these molecules. Emphasis has been placed on small molecules and multi-target-directed ligands, as well as disease-modifying therapies. Finally, attention is drawn to the possibilities of applications of nanotechnology in managing dementia. MDPI 2023-01-19 /pmc/articles/PMC9965722/ /pubmed/37259302 http://dx.doi.org/10.3390/ph16020151 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zagórska, Agnieszka
Czopek, Anna
Fryc, Monika
Jaromin, Anna
Boyd, Ben J.
Drug Discovery and Development Targeting Dementia
title Drug Discovery and Development Targeting Dementia
title_full Drug Discovery and Development Targeting Dementia
title_fullStr Drug Discovery and Development Targeting Dementia
title_full_unstemmed Drug Discovery and Development Targeting Dementia
title_short Drug Discovery and Development Targeting Dementia
title_sort drug discovery and development targeting dementia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9965722/
https://www.ncbi.nlm.nih.gov/pubmed/37259302
http://dx.doi.org/10.3390/ph16020151
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